A5100384252- Mosquito-borne diseases and control
- Escherichia coli research studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Malaria Research and Control
- Bacteriophages and microbial interactions
- Hepatitis B Virus Studies
- Antimicrobial Peptides and Activities
- Animal Virus Infections Studies
- Bacterial Genetics and Biotechnology
- Vibrio bacteria research studies
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- MicroRNA in disease regulation
- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Poxvirus research and outbreaks
- Hepatitis C virus research
- DNA Repair Mechanisms
- Nanoplatforms for cancer theranostics
- HIV Research and Treatment
- Biosensors and Analytical Detection
- Cancer-related gene regulation
Southern Medical University
2016-2025
Zhujiang Hospital
2023-2024
University of Southern California
2015-2023
Guangzhou Medical University
2023
Fifth Affiliated Hospital of Xinjiang Medical University
2023
Kunming Children's Hospital
2023
Xinjiang Medical University
2023
Jiangxi Agricultural University
2022
Dalian Medical University
2021
Key Laboratory of Guangdong Province
2020
The molecular mechanisms underlying dysregulation of microRNAs have been documented in nasopharyngeal carcinoma (NPC). Our previous study demonstrated that plasma miR-124 was down-regulated NPC using microarray analysis and quantitative PCR validation. Though growing studies showed closely related to tumourigenesis various types cancers, the role remains largely unknown. expression level evaluated cell lines patient specimens reverse transcription-PCR (Real-time qPCR). clinicopathological...
The worldwide outbreak of the monkeypox virus (MPXV) has become a "Public Health Emergency International Concern" (PHEIC). Severe infection can be fatal, however, effective therapeutic methods are yet to developed. Mice were immunized with A35R protein and A29L MPXV, binding neutralizing activities immune sera against poxvirus-associated antigens viruses identified. protein-specific monoclonal antibodies (mAbs) generated their antiviral these mAbs characterized in vitro vivo. Immunization...
Bacillomycin L, a natural iturinic lipopeptide produced by Bacillus amyloliquefaciens, is characterized strong antifungal activities against variety of agronomically important filamentous fungi including Rhizoctonia solani Kühn. Prior to this study, the role membrane permeabilization in antimicrobial activity bacillomycin L plant pathogenic had not been investigated. To shed light on mechanism activity, R. hyphae was investigated and compared with that amphotericin B, polyene antibiotic...
Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic type of cancer that widely prevalent in Southern China. Studies have shown several microRNAs (miRNAs) are implicated NPC metastasis. Our previous studies demonstrated miRNA miR-26a inhibits cell growth tumorigenesis through the repression enhancer zeste homolog 2 (EZH2). However, role metastasis remains unknown. In this study, we showed ectopic expression inhibited migratory capacities cells vitro. Additionally, used murine...
Abstract Background MicroRNAs (miRNAs) have been shown to play a critical role in the development and progression of nasopharyngeal carcinoma (NPC). Although accumulating studies performed on molecular mechanisms NPC, miRNA regulatory networks cancer remain largely unknown. Laser capture microdissection (LCM) deep sequencing are powerful tools that can help us detect integrated view miRNA-target network. Methods Illumina Hiseq2000 was used screen differentially expressed miRNAs...
The Epstein-Barr virus (EBV)-encoded EB nuclear antigen 1 (EBNA1) protein is required for maintenance and transmission of the viral episome in EBV-infected cells. objective this study was to investigate role EBNA1 nasopharyngeal carcinoma (NPC).Tissue samples from 48 patients with NPC 12 chronic nasopharyngitis were subjected immunohistochemical analysis expression. combinational DNA used overexpress cell lines assess tumor epithelial-mesenchymal transition (EMT), colony formation, migration...
Chlamydia trachomatis, the most prevalent bacterial agent of sexually transmitted infections , poses a significant threat to reproductive health. The release progeny through orchestrated lysis host cells plays crucial role for development new infections, though underlying molecular mechanisms remaining largely unexplored. In this study, we identified novel mechanism by which induces cell ferroptosis facilitate its release. This process involves degradation protein SLC7A11 chlamydial...
Abstract Background The VP1 protein of enterovirus 71 (EV71) is an important immunodominant which responsible for host-receptor binding. Nevertheless, the relationship between and neurovirulence still poorly understood. In this study, we investigated mutation neurovirulent phenotype EV71 infection. Methods One hundred eighty-seven strains from Genbank were included, with a clear clinical background. They divided into two groups, one nervous system symptoms no symptoms. After alignment,...
Background NF-κB activation, pathogen invasion, polymorphonuclear leukocytes (PMN) transmigration (PMNT) across the blood-brain barrier (BBB) are pathogenic triad hallmark features of bacterial meningitis, but mechanisms underlying these events remain largely unknown. Vimentin, which is a novel regulator, primary receptor for major Escherichia coli K1 virulence factor IbeA that contributes to pathogenesis neonatal sepsis and meningitis (NSM). We have previously shown IbeA-induced signaling...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global pandemic that has currently infected over 430 million individuals worldwide. With the variant strains of SARS-CoV-2 emerging, region high mutation rates in ORF8 was identified during early pandemic, which resulted from leucine (L) to serine (S) at amino acid 84. A typical feature immune evasion suppressing interferon response; however, mechanisms two variants antagonize...
In 2022, the monkeypox virus (mpox virus, MPXV) exhibited global dissemination across six continents, representing a notable challenge owing to scarcity of targeted antiviral interventions. Passive immunotherapy, such as use monoclonal antibodies (mAbs) and bispecific (bsAbs), has emerged promising option for regimens. Here, we generated several mAbs against M1R B6R MPXV, subsequently characterized activity these both
Since 2015, 84 countries and territories reported evidence of vector-borne Zika Virus (ZIKV) transmission. The World Health Organization (WHO) declared that ZIKV associated consequences especially the neurological autoimmune disorder Guillain–Barré syndrome (GBS) microcephaly will remain a significant enduring public health challenge requiring intense action. We apply standardization multi-subcutaneous dorsal inoculation method to systematically summarize clinical manifestation, viral...
ABSTRACT Attaching/effacing (A/E) pathogens induce DNA damage and colorectal cancer by injecting effector proteins into host cells via the type III secretion system (T3SS). EspF is one of T3SS-dependent exclusive to A/E pathogens, which include enterohemorrhagic Escherichia coli . The role in induction double-strand breaks (DSBs) phosphorylation repair protein SMC1 has been demonstrated previously. However, process accumulation DSB formation remained enigmatic, response not well understood....
Abstract One of the most challenging issues in HIV-associated neurocognitive disorders (HAND) caused by HIV-1 virotoxins and drug abuse is lack understanding underlying mechanisms that are commonly associated with blood-brain barrier (BBB), which mainly consists brain microvascular endothelial cells (BMEC). Here, we hypothesized Glycoprotein 120 (gp120), methamphetamine (METH) nicotine (NT) can enhance amyloid-beta (Aβ) accumulation BMEC through Alpha7 nicotinic acetylcholine receptor (α7...
Abstract Tbx3, a transcriptional repressor, is essential in the organogenesis of vertebrates, stem cell self-renewal and differentiation, carcinogenesis multiple tumor types. However, mechanism by which Tbx3 participates metastasis hepatocellular carcinoma (HCC) remains largely unknown. In this study, we show that was dramatically upregulated clinical HCC samples elevated expression promoted cancer progression. To determine underlying mechanism, systematic glycine scan mutagenesis deletion...
Neonatal sepsis and meningitis (NSM) remains a leading cause worldwide of mortality morbidity in newborn infants despite the availability antibiotics over last several decades. E. coli is most common gram-negative pathogen causing NSM. Our previous studies show that α7 nicotinic receptor (α7 nAChR), an essential regulator inflammation, plays detrimental role host defense against Despite notable successes, there still exists unmet need for new effective therapeutic approaches to treat this...
Cryptococcal meningitis is the most common fungal infection of central nervous system (CNS) in HIV/AIDS. HIV-1 virotoxins (e.g., gp41) are able to induce disorders blood-brain barrier (BBB), which mainly consists BMEC. Our recent study suggests that α7 nAChR an essential regulator inflammation, contributes regulation NF-κB signaling, neuroinflammation and BBB caused by microbial gp120) non-microbial [e.g., methamphetamine (METH)] factors. However, underlying mechanisms for multiple...
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 EspF is an important multifunctional protein that destroys the tight junctions of intestinal epithelial cells and promotes host cell apoptosis. However, its molecular mechanism remains elusive. We knocked out espF sequence (747 bp, ΔespF), N-terminal (219 ΔespFN ), C-terminal (528 ΔespFC ) separately using pKD46-mediated λ Red homologous recombination system. Then, we built corresponding complementation strains, namely, ΔespF/pespF,...