A5101464067- Herpesvirus Infections and Treatments
- Poxvirus research and outbreaks
- Sulfur-Based Synthesis Techniques
- Plant Virus Research Studies
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- Photosynthetic Processes and Mechanisms
- RNA Interference and Gene Delivery
- Radical Photochemical Reactions
- Advanced biosensing and bioanalysis techniques
- Advanced Photocatalysis Techniques
- Nanoparticle-Based Drug Delivery
- Knee injuries and reconstruction techniques
- Neonatal Respiratory Health Research
- Protease and Inhibitor Mechanisms
- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Drug Transport and Resistance Mechanisms
- Multicomponent Synthesis of Heterocycles
- Radar Systems and Signal Processing
- Stroke Rehabilitation and Recovery
- Pharmacological Effects of Natural Compounds
- Advanced Drug Delivery Systems
- Thermoregulation and physiological responses
Southern Medical University
2022-2024
Zhujiang Hospital
2023-2024
Fuzhou University
2024
Henan University
2024
Nanjing University of Science and Technology
2024
National Clinical Research Center for Digestive Diseases
2024
Huazhong Agricultural University
2023
Xiamen University
2023
Zunyi Medical University
2023
Shanghai Jiao Tong University
2022
The worldwide outbreak of the monkeypox virus (MPXV) has become a "Public Health Emergency International Concern" (PHEIC). Severe infection can be fatal, however, effective therapeutic methods are yet to developed. Mice were immunized with A35R protein and A29L MPXV, binding neutralizing activities immune sera against poxvirus-associated antigens viruses identified. protein-specific monoclonal antibodies (mAbs) generated their antiviral these mAbs characterized in vitro vivo. Immunization...
Abstract Understanding of infection dynamics is important for public health measures against monkeypox virus (MPXV) infection. Herein, samples from multiple body sites and environmental fomites 77 acute MPXV infections (HIV co-infection: N = 42) were collected every two to three days used detection DNA, surface protein specific antibodies neutralizing titers. Skin lesions show 100% positivity rate followed by rectum (88.16%), saliva (83.78%) oropharynx (78.95%). Positivity decreases rapidly...
Abstract Background Schwann cell-like cells (SCLCs), differentiated from mesenchymal stem cells, have shown promising outcomes in the treatment of peripheral nerve injuries preclinical studies. However, certain clinical obstacles limit their application. Hence, primary aim this study was to investigate role exosomes derived SCLCs (SCLCs-exo) regeneration. Methods were human amniotic (hAMSCs) vitro and validated by immunofluorescence, real-time quantitative PCR western blot analysis. Exosomes...
Recently, the monkeypox virus (MPXV) outbreak was once again declared by World Health Organization as a global health emergency, and currently, there is no specific drug against MPXV. During replication cycle, MPXV produces two distinct forms of viral particles: extracellular enveloped (EEV), released via exocytosis, intracellular mature (IMV), expelled through host cell lysis. A29 B6 proteins are membrane found on IMV EEV particles, respectively. This study designed different bispecific...
In 2022, the monkeypox virus (mpox virus, MPXV) exhibited global dissemination across six continents, representing a notable challenge owing to scarcity of targeted antiviral interventions. Passive immunotherapy, such as use monoclonal antibodies (mAbs) and bispecific (bsAbs), has emerged promising option for regimens. Here, we generated several mAbs against M1R B6R MPXV, subsequently characterized activity these both
Laser speckle contrast imaging (LSCI) is widely used for in vivo real-time detection and analysis of local blood flow microcirculation due to its non-invasive ability excellent spatial temporal resolution. However, vascular segmentation LSCI images still faces a lot difficulties numerous specific noises caused by the complexity microcirculation's structure irregular aberrations diseased regions. In addition, image data annotation have hindered application deep learning methods based on...
Abstract A novel and efficient approach for the synthesis of α, β‐unsaturated sulfones through heterogeneous photocatalyzed C−S coupling reactions have been developed. The use molten‐salt method derived carbon nitride (MCN), a transition metal‐free polymeric photocatalyst, combined with enhanced crystallinity potassium iodide as an additive, effectively modulates photogenerated reactive redox species, markedly increasing overall reaction selectivity. This achieves shortest time (2 h) high...
A one-pot three-component reaction for the synthesis of 4-thiazolidinone derivatives has been established by reacting readily available and inexpensive starting materials amines, aldehydes thioglycolic acid using Y(OTf)3 (5 mol%) as catalyst in tetrahydrofuran. This method is very efficient due to low loading mild conditions provides an promising synthetic strategy construction thiazolidinone skeleton.
<title>Abstract</title> <bold>Background</bold> Elucidating the viral and antibody dynamics within host of environmental fomits is key for successful public health measures against monkeypox virus (MPXV) infection. In this study, a total 993 samples from multiple sites patients 1,633 77 acute MPXV infections (HIV co-infection: N=42) were collected every two to three days subjected detection DNA, surface proteins specific neutralizing titers. Overall, skin lesions showed 100% positive rate...
1. This study aimed to investigate the potential impact of epigallocatechin-3-gallate (EGCG) on pharmacokinetic behaviors simvastatin and its metabolite acid explored possible role metabolizing enzymes transporters this food-drug interaction. 2. Female SD rats were intravenously administered with EGCG (5 mg/kg), ketoconazole (10 mg/kg) rifampin followed by intravenous administration 2 mg/kg simvastatin. In vitro, effects Cytochrome P450 (CYP450) organic anion transporting polypeptides...
The present study was designed to assess the pharmacokinetic and pharmacodynamic performance of inhaled recombinant human insulin (rh-insulin) dry powders together with their safety profiles after 14-day inhalation.In study, pulmonary surfactant (PS)-loaded phospholipid hexadecanol tyloxapol (PHT)-loaded rh-insulin were intratracheally administered male rats at dose 20 U/kg. Novolin R used as control. Serum glucose concentrations determined by oxidase method CLIA kit, respectively. For...