A5028485839- Thyroid Cancer Diagnosis and Treatment
- Allergic Rhinitis and Sensitization
- Cancer-related molecular mechanisms research
- Food Allergy and Anaphylaxis Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Natural Compounds in Disease Treatment
- RNA Research and Splicing
- Monoclonal and Polyclonal Antibodies Research
- Radiomics and Machine Learning in Medical Imaging
- Asthma and respiratory diseases
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Microfluidic and Bio-sensing Technologies
- Eosinophilic Esophagitis
- Advanced biosensing and bioanalysis techniques
- Cell Adhesion Molecules Research
- Gut microbiota and health
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Optical Coherence Tomography Applications
- NF-κB Signaling Pathways
- Cancer, Hypoxia, and Metabolism
Tianjin Medical University
2016-2025
Harbin Medical University
2025
First Affiliated Hospital of Harbin Medical University
2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2025
University of Electronic Science and Technology of China
2025
Chongqing Medical University
2019-2024
Dalian Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Blood Center of Zhejiang Province
2021-2022
Chengdu University of Traditional Chinese Medicine
2022
// Li Ren 1, 2, * , Yang Yu Wang 2 Zhifeng Zhu Rong Lu Zhi Yao 1 Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Research Center for Cancer, Key Laboratory Prevention Therapy, Tianjin’s Tianjin, P.R. China Immunology, Cellular Molecular Educational Ministry China, School Sciences, University, These authors have contributed equally to this work Correspondence to: Yao, email: yaozhi@tmu.edu.cn Keywords: CCL28, Treg, HCC, angiogenesis,...
The incidence of papillary thyroid carcinoma (PTC) has exponentially increased in recent years. Papillary microcarcinoma (PTMC) accounts for the majority reported cases PTC. debates and crucial issues PTMC management have received researchers' attention. To further improve
Intestinal dysbiosis plays a critical role in the pathogenesis of Parkinson's disease (PD), and probiotics have emerged as potential modulators central nervous system function through microbiota-gut-brain axis. This study aimed to elucidate anti-inflammatory effects underlying mechanisms probiotic strain Bifidobacterium animalis subsp. lactis NJ241 (NJ241) mouse model PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The impact was comprehensively assessed mice behavioral...
The TGF-β, a tumor suppressive cytokine in normal cells, is abused cancer to promote the malignancy. In this study, we reported that TGF-β downregulated mutS homolog 2 (MSH2), central component of DNA mismatch repair (MMR) system, HER2-transformed MCF10A mammary epithelial cells and breast (BC) cells. This was mediated by TGF-β-induced micro RNA (miRNA), miR-21, which targeted 3' untranslated region MSH2 mRNA its expression. A negative correlation between expression TGF-β1 also detected...
The epithelial to mesenchymal transition (EMT) is a developmental program in which cells downregulate their cell-cell junctions, acquire spindle cell morphology and exhibit cellular motility. In breast cancer, EMT facilitates invasion of surrounding tissues correlates closely with cancer metastasis relapse. We found previously that the candidate tumor suppressor CLCA2 expressed differentiated, growth-arrested mammary but downregulated during progression EMT. further demonstrated...
Mounting evidence shows that long noncoding RNAs play important roles in human diseases and radioresistance could be an factor for tumor recurrence. We observed HOX antisense intergenic RNA (
Background: Pudendal neuralgia is an intractable pain related to the pudendal nerve. The clinical effect and safety evaluation of were investigated by pulse radiofrequency (PRF) treatment Patients methods: Eighty patients who diagnosed with randomly divided into PRF group (PRF nerve block [NB]) NB group. After surgery, followed up evaluate visual analog scale (VAS) score Patient Health Questionnaire on postoperative day at 2 weeks, 1 3 months. Meanwhile, patients' efficacy assessment usage...
In real-world recommendation scenarios, users engage with items through various types of behaviors. Leveraging diversified user behavior information for learning can enhance the target behaviors (e.g., buy), as demonstrated by recent multi-behavior methods. The mainstream framework consists two steps: fusion and prediction. Recent approaches utilize graph neural networks employ multi-task paradigms joint optimization in prediction step, achieving significant success. However, these methods...
The purpose of this study is to establish a light-initiated chemiluminescence assay (LiCA) for the quantitative analysis Humulus scandens pollen-specific IgE (sIgE) antibodies. best chemibeads coupling method in detecting pollen - sIgE was selected. working concentrations antigen-antibody and reaction buffer were optimized as components system. Then performance evaluated results LiCA compared with ImmunoCAP methods. In range 0.23 kUA/L 100.51 kUA/L, demonstrated good linearity. coefficients...
This study aimed to investigate the expression condition of a proliferation-inducing ligand (APRIL) in lacrimal gland lesions patients with IgG4-associated ophthalmic diseases (IgG4-ROD) and mucosa-associated lymphoid tissue (MALT) lymphoma. Fifteen IgG4-ROD, 3 MALT lymphoma, 1 elevated IgG4 lesions, treated West China Hospital Sichuan University from April 2022 November 2023, were included. Immunofluorescence staining was used detect APRIL specimen gland. The average level IgG4-ROD lymphoma...
ABSTRACT Background Although triptolide has demonstrated efficacy in treating oral squamous cell carcinoma (OSCC), its precise molecular mechanism remains unclear. This study investigated the underlying triptolide's action lncRNA‐mediated competing endogenous RNA (ceRNA) regulation. Methods The impact of on OSCC vivo was validated using a xenograft tumor model. Whole‐transcriptome sequencing and bioinformatics analysis were conducted to construct lncRNA‐miRNA‐mRNA regulatory network....
Nanoneedle arrays of heterostructured RuO2-Co3O4 electrocatalysts were constructed, showing improved water oxidation activity and durable stability. The synergy tip-effect-induced OH- enrichment, superior hydrophilicity, heterojunction-enhanced electron transfer promotes activity.
Abstract The regulation and function of the signaling adaptor protein p130 Cas in tumor cell anchorage‐independent survival, or anoikis resistance, were investigated human lung adenocarcinoma cells. tyrosine phosphorylation during detachment analyzed cells compared with that normal epithelial Cell trigged rapid dephosphorylation nontumorigenic anoikis‐sensitive cells, but had no effect on anoikis‐resistant Further analysis revealed total kinase activities associated are significantly higher...
Background/Aims: Iodine may trigger tumorigenesis and development of thyroid carcinoma, but the mechanisms involved remained elusive. MicroRNA (MiRNAs) are known to be in each stage cancer development; however, role miRNAs iodine-induced carcinoma unknown. In this study, we aimed at investigating miRNA related signaling pathway cells. Methods: Levels mRNAs were determined using RT-qPCR proteins quantified by western blotting. Cell migration proliferation checked Transwell assay CCK8...
Abstract Vascular endothelial growth factor ( VEGF ) is a critical angiogenic affecting cells, inflammatory cells and neuronal cells. In addition to its well‐defined positive role in wound healing, pathological roles for have been described cancer diseases i.e . atherosclerosis, rheumatoid arthritis, bowel disease osteoarthritis). Recently, we showed that transcription factors LITAF STAT6B affected the response. This study builds upon our previous results testing of mouse regulation...
// Lei Liang 1, 2, * , Xue Yang Yu 3, Xiaoyong Li 2 Yechen Wu Rongyu Shi 1 Jinghua Jiang Lu Gao Fei Ye Qiudong Zhao Rong Lixin Wei Zhipeng Han Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai, China College of Soochow Suzhou, 3 Department General Surgery, Yangpu Tongji University School Medicine, 200065, These authors contributed equally to this work Correspondence to: Han, email: hanzhipeng0311@126.com Wei,...