A5100742600- Gut microbiota and health
- Genomics, phytochemicals, and oxidative stress
- Cancer-related molecular mechanisms research
- Mycotoxins in Agriculture and Food
- Carcinogens and Genotoxicity Assessment
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Bioactive Compounds and Antitumor Agents
- Liver Disease Diagnosis and Treatment
- Analytical Chemistry and Chromatography
- MicroRNA in disease regulation
- Tea Polyphenols and Effects
- Synthesis and Biological Evaluation
- Alzheimer's disease research and treatments
- Antibiotics Pharmacokinetics and Efficacy
- Antioxidant Activity and Oxidative Stress
- Natural product bioactivities and synthesis
- Biochemical Acid Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Plant Toxicity and Pharmacological Properties
- Food composition and properties
- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Electrochemical sensors and biosensors
Huazhong University of Science and Technology
2016-2025
Changchun University of Chinese Medicine
2023-2025
China National Center for Food Safety Risk Assessment
2025
Sun Yat-sen University
2016-2024
Sun Yat-sen University Cancer Center
2016-2024
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2024
South China Normal University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2024
King Abdullah University of Science and Technology
2024
State Key Laboratory of Food Science and Technology
2016-2024
Introduction: Human gut microbiota is believed to be directly or indirectly involved in cardiovascular diseases and hypertension. However, the identification functional status of hypertension-related microbe(s) have not yet been surveyed a comprehensive manner. Methods: Here we characterized microbiome hypertension by comparing fecal samples 60 patients with primary gender-, age-, body weight-matched healthy controls based on whole-metagenome shotgun sequencing. Results: Hypertension...
Long noncoding RNA (lncRNA) MEG3 is an important tumor suppressor in several types of human cancers. However, the biological function and underlying mechanism vascular endothelial cells (VECs) remain unknown. In present study, we demonstrated functional importance lncRNA proliferation angiogenesis VECs. overexpression significantly suppressed vitro VECs, whereas knockdown had opposite effect. Furthermore, found that exerts its through negatively regulating miR-9 by acting as a microRNA...
Abstract Brain insulin resistance, induced by neuroinflammation and oxidative stress, contributes to neurodegeneration, that is, processes are associated with Aβ accumulation TAU hyperphosphorylation. Here, we tested the effect of chronic administration melatonin (MLT) on brain resistance cognition deficits caused a high‐fat diet (HFD) in aged rats. Results showed MLT supplementation attenuated peripheral lowered hippocampal stress levels. Activated microglia astrocytes levels TNF‐α HFD‐fed...
Background Circulating concentrations of heme oxygenase-1 (HO-1) have been recently reported to be elevated in several chronic disorders. However, no study has ever examined the association between circulating HO-1 and type 2 diabetes mellitus (T2DM). Methods Findings 581 cases with newly-diagnosed T2DM (New-T2DM) 611 comparison controls were recruited this two-phase case-control study, comprising 420 429 collected first phase 161 182 second replication study. Analyses, using both separated...
Manganese is both an essential element and a known toxicant, it plays important roles in many mechanisms relation to type 2 diabetes (T2D). However, epidemiological studies of this relationship are rare.
Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) related imbalance, Tau-hyperphosphorylation, and neuroinflammation, in which Aβ neuroinflammation can induce brain insulin resistance (IR). Gut microbiome disorder correlated with inflammation AD. As of yet, there are no effective treatments clinically. Thus, it focused on the potential benefit quercetin-3-O-glucuronide (Q3G), a pharmacologically active flavonol glucuronide, AD treatment regulating IR gut microbiome.
Metabonomics is an important platform for investigating the metabolites of integrated living systems and their dynamic responses to changes caused by both endogenous exogenous factors. A metabonomics strategy based on liquid chromatography-mass spectrometry/mass spectrometry in positive negative ion modes was applied investigate short-term long-term stability plasma. Principal components analysis ten types identified were used summarize time-dependent change rules systematically at different...
It is essential to choose one preprocessing method for liquid chromatography-mass spectrometry (LC-MS)-based metabolomics studies of urine samples in order overcome their variability. However, the commonly used normalization methods do not substantially reduce high variabilities arising from differences concentration, especially signal saturation (abundant metabolites exceed dynamic range instrumentation) or missing values. Herein, a simple preacquisition strategy based on differential...
Rumen epithelial Na(+)/H(+) exchanger (NHE) catalyzes the exchange of extracellular Na(+) for intracellular H(+). Thus, it is importance in maintenance Na and pH homeostasis rumen cells. We have tested hypothesis that an increase energy protein intake induces alterations NHE isoform 1, 2, 3 (NHE1, NHE1, NHE3, respectively) mRNA abundance epithelium goats. Goats (n = 26) were randomly allocated to 2 experiments 16 Exp. n 10 2) fed either peanut straw ad libitum [PNS, 8 5 2; 600 kJ...
Hepatic lipid accumulation and oxidative stress are crucial pathophysiological mechanisms for non-alcoholic fatty liver disease (NAFLD). Thus, we examined the effect of a combination flaxseed oil (FO) astaxanthin (ASX) on hepatic in rats fed high-fat diet. ASX was dissolved (1 g/kg; FO + ASX). Animals were diets containing 20% fat, where source lard, or 75% lard 25% ASX, 50% 10 weeks. Substitution with reduced steatosis triacylglycerol cholesterol. The significantly decreased sterol...
Abstract Objective: To explore the safety of ultrasound and microbubbles for enhancing chemotherapeutic sensitivity malignant tumors in digestive system a clinical trial, as well its efficacy. Methods: From October 2014 to June 2016, twelve patients volunteered participate this study. Eleven had hepatic metastases from system, one patient pancreatic carcinoma. According mechanical index (MI) field, were classified into four groups with MIs 0.4, 0.6, 0.8 1.0. Within half an hour after...
Quantitative metabolomics approaches can significantly improve the repeatability and reliability of investigations but face critical technical challenges, owing to vast number unknown endogenous metabolites lack authentic standards. The present study contributes development a novel method known as "data-independent targeted quantitative metabolomics" (DITQM), which was used investigate label-free multiple in biofluid samples. This approach initially involved acquisition MS/MS data for all...
To examine the associations of plasma copper concentrations and superoxide dismutase 1 (SOD1) polymorphisms as well their gene-environment interaction with newly diagnosed impaired glucose regulation (IGR) type 2 diabetes (T2D). We performed a large case-control study in 2520 Chinese Han subjects: 1004 T2D patients, 512 IGR patients individuals normal tolerance. After multivariable adjustment, ORs (95% CIs) across tertiles were 1.00 (reference), 1.85 CI: 1.39, 2.45), 4.21 3.20, 5.55)...