Zhilei Shan

ORCID: 0000-0002-6723-3381
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About
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Research Areas
  • Nutritional Studies and Diet
  • Diet and metabolism studies
  • Obesity, Physical Activity, Diet
  • Nutrition, Genetics, and Disease
  • Trace Elements in Health
  • Consumer Attitudes and Food Labeling
  • Antioxidant Activity and Oxidative Stress
  • Liver Disease Diagnosis and Treatment
  • Folate and B Vitamins Research
  • Heavy Metal Exposure and Toxicity
  • Birth, Development, and Health
  • Diet, Metabolism, and Disease
  • Alzheimer's disease research and treatments
  • Nutrition and Health in Aging
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Sleep and related disorders
  • Vitamin D Research Studies
  • Gut microbiota and health
  • Chromium effects and bioremediation
  • Sleep and Work-Related Fatigue
  • Cardiovascular Health and Risk Factors
  • Lipoproteins and Cardiovascular Health
  • Gestational Diabetes Research and Management
  • Agriculture Sustainability and Environmental Impact
  • Eating Disorders and Behaviors

Lanzhou University
2024

State Key Laboratory of Applied Organic Chemistry
2024

Huazhong University of Science and Technology
2015-2024

Harvard University
2017-2023

Tongji University
2013-2021

Brigham and Women's Hospital
2021

Cambridge University Press
2021

New York University Press
2021

Osaka University
2021

Tufts University
2019-2020

<h3>Importance</h3> Changes in the economy, nutrition policies, and food processing methods can affect dietary macronutrient intake diet quality. It is essential to evaluate trends intake, sources, quality inform policy makers. <h3>Objective</h3> To investigate among US adults. <h3>Design, Setting, Participants</h3> Serial cross-sectional analysis of nationally representative 24-hour recall data from 9 National Health Nutrition Examination Survey cycles (1999-2016) adults aged 20 years or...

10.1001/jama.2019.13771 article EN JAMA 2019-09-24

The 2015-2020 Dietary Guidelines for Americans recommend multiple healthy eating patterns. However, few studies have examined the associations of adherence to different dietary patterns with long-term risk cardiovascular disease (CVD).To examine scores 4 incident CVD.Prospective cohort study initially women from Nurses' Health Study (NHS) (1984-2016) and NHS II (1991-2017) men Professionals Follow-up (HPFS) (1986-2012). dates analysis were July 25 December 4, 2019.Healthy Eating Index-2015...

10.1001/jamainternmed.2020.2176 article EN JAMA Internal Medicine 2020-06-15

Abstract Objectives To prospectively evaluate the joint association of duration rotating night shift work and lifestyle factors with risk type 2 diabetes risk, to quantitatively decompose this only, their interaction. Design Prospective cohort study. Setting Nurses’ Health Study (1988-2012) II (1991-2013). Participants 143 410 women without diabetes, cardiovascular disease, or cancer at baseline. Exposures Rotating was defined as least three shifts per month in addition day evening that...

10.1136/bmj.k4641 article EN cc-by-nc BMJ 2018-11-21

<h3>Importance</h3> It is crucial to incorporate quality and types of carbohydrate fat when investigating the associations low-fat low-carbohydrate diets with mortality. <h3>Objective</h3> To investigate total cause-specific mortality among US adults. <h3>Design, Setting, Participants</h3> This prospective cohort study used data from National Health Nutrition Examination Survey 1999 2014 37 233 adults 20 years or older 24-hour dietary recall data. Data were analyzed July 5 August 27, 2019....

10.1001/jamainternmed.2019.6980 article EN JAMA Internal Medicine 2020-01-21

OBJECTIVE Although carotenoids have been suggested to exhibit antioxidant properties, some experimental studies reported that β-carotene may show pro-oxidant effects under certain conditions. Current evidence regarding the cardiovascular of among patients with type 2 diabetes (T2D) is scarce. This study aimed prospectively examine associations individual serum carotenoid concentrations mortality adults T2D. RESEARCH DESIGN AND METHODS analysis included 3,107 individuals T2D from Third...

10.2337/dc21-2371 article EN Diabetes Care 2022-05-03

The current Dietary Guidelines for Americans recommend multiple healthy eating patterns. However, few studies have examined the associations of adherence to different dietary patterns with long-term risk total and cause-specific mortality.

10.1001/jamainternmed.2022.6117 article EN JAMA Internal Medicine 2023-01-09

Unhealthy sleep behaviors and disturbances are associated with higher risk of multiple diseases mortality. The current profiles habits disturbances, particularly the differences between workdays free days, unknown in contemporary US.To comprehensively evaluate on days prevalence among US adults.This study is a cross-sectional analysis nationally representative data from National Health Nutrition Examination Survey (2017-2020) adults aged 20 years or older. Data was performed February to May...

10.1001/jamanetworkopen.2022.40788 article EN cc-by-nc-nd JAMA Network Open 2022-11-08

Importance Improved understanding of trends in the proportion individuals with metabolically healthy obesity (MHO) may facilitate stratification and management inform policy efforts. Objectives To characterize prevalence MHO among US adults obesity, overall by sociodemographic subgroups. Design, Setting, Participants This survey study included 20 430 adult participants from 10 National Health Nutrition Examination Survey (NHANES) cycles between 1999-2000 2017-2018. The NHANES is a series...

10.1001/jamanetworkopen.2023.2145 article EN cc-by-nc-nd JAMA Network Open 2023-03-09

Diet is an important risk factor for cancer that amenable to intervention. Estimating the burden associated with diet informs evidence-based priorities nutrition policies reduce in United States.

10.1093/jncics/pkz034 article EN cc-by JNCI Cancer Spectrum 2019-04-30

BackgroundMicroRNAs (miRNAs), a class of small non-coding RNAs, are thought to serve as crucial regulators gene expression. Dysregulated expression miRNAs has been described in various diseases and may contribute related pathologic processes. Our aim was examine circulating miRNA-146a levels newly diagnosed type 2 diabetes mellitus (new-T2DM) patients from Chinese Han population. Methodology/Principal FindingsCirculating extracted plasma samples 90 new-T2DM age- sex-matched controls....

10.1371/journal.pone.0073272 article EN cc-by PLoS ONE 2013-09-02

To determine whether a healthful plant-based diet is related to lower stroke risk, we examined the associations of quality with risk total, ischemic, and hemorrhagic stroke.The participants were 73,890 women in Nurses' Health Study (NHS; 1984-2016), 92,352 NHSII (1991-2017), 43,266 men Professionals Follow-Up (1986-2012) without cardiovascular disease cancer at baseline. Plant-based was evaluated by overall index (PDI), PDI (hPDI), unhealthful (uPDI). Participants who reported that their...

10.1212/wnl.0000000000011713 article EN Neurology 2021-03-10

OBJECTIVE Evidence is limited regarding the associations between vitamin D status and microvascular complications in individuals with type 2 diabetes (T2D), among whom deficiency or insufficiency particularly common. In this study we aimed to prospectively investigate of serum 25-hydroxyvitamin [25(OH)D] receptor (VDR) polymorphisms risk diabetic complications. RESEARCH DESIGN AND METHODS This analysis included 14,709 participants T2D who were free from UK Biobank. Incidence was ascertained...

10.2337/dc22-0513 article EN Diabetes Care 2022-09-28

Synbiotics are increasingly used by the general population to boost immunity. However, there is limited evidence concerning immunomodulatory effects of synbiotics in healthy individuals. Therefore, we conducted a double-blind, randomized, placebo-controlled study 106 adults. Participants were randomly assigned receive either (containing Bifidobacterium lactis HN019 1.5 × 108 CFU/d, Lactobacillus rhamnosus HN001 7.5 107 and fructooligosaccharide 500 mg/d) or placebo for 8 weeks. Immune...

10.1080/19490976.2023.2247025 article EN cc-by-nc Gut Microbes 2023-08-23

Importance Adherence to a healthy lifestyle is associated with lower risks of adverse outcomes. However, trends in multiple factors and overall status among US adults recent years are unknown. Objective To examine adults. Design, Setting, Participants This serial cross-sectional study used nationally representative data from 10 National Health Nutrition Examination Survey (NHANES) cycles (nine 2-year 1999 2016 1 combined cycle 2017 March 2020) 20 or older. Data were analyzed December 10,...

10.1001/jamanetworkopen.2023.23584 article EN cc-by-nc-nd JAMA Network Open 2023-07-14

Although both SLC30A8 rs13266634 single nucleotide polymorphism and plasma zinc concentrations have been associated with impaired glucose regulation (IGR) type 2 diabetes (T2D), their interactions for IGR T2D remain unclear. Therefore, to assess zinc-SLC30A8 interactions, we performed a case-control study in 1,796 participants: 218 newly diagnosed patients, 785 793 individuals normal tolerance. After adjustment age, sex, BMI, family history of diabetes, hypertension, the multivariable odds...

10.2337/db13-0606 article EN cc-by-nc-nd Diabetes 2013-12-05
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