A5045890417- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Pancreatic and Hepatic Oncology Research
- Cancer Risks and Factors
- Consumer Attitudes and Food Labeling
- Genetic Syndromes and Imprinting
- Nutrition, Genetics, and Disease
- Vitamin D Research Studies
- Nutrition and Health in Aging
- RNA modifications and cancer
- Food Security and Health in Diverse Populations
- Cancer Mechanisms and Therapy
- Obesity, Physical Activity, Diet
- Genetic Associations and Epidemiology
- Agriculture Sustainability and Environmental Impact
- Cancer-related gene regulation
- Childhood Cancer Survivors' Quality of Life
- Air Quality and Health Impacts
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Family and Patient Care in Intensive Care Units
- Complementary and Alternative Medicine Studies
- Immune responses and vaccinations
- Nutrition, Health and Food Behavior
- Cardiovascular Health and Risk Factors
Harvard University
2024
Brigham and Women's Hospital
2022-2024
Tufts University
2019-2022
Woman's Hospital
2022
Massachusetts General Hospital
2022
New York University Press
2021
Cambridge University Press
2021
<h3>Importance</h3> Changes in the economy, nutrition policies, and food processing methods can affect dietary macronutrient intake diet quality. It is essential to evaluate trends intake, sources, quality inform policy makers. <h3>Objective</h3> To investigate among US adults. <h3>Design, Setting, Participants</h3> Serial cross-sectional analysis of nationally representative 24-hour recall data from 9 National Health Nutrition Examination Survey cycles (1999-2016) adults aged 20 years or...
The health benefits and risks of dietary supplement use are controversial.
Diet is an important risk factor for cancer that amenable to intervention. Estimating the burden associated with diet informs evidence-based priorities nutrition policies reduce in United States.
Abstract Not all plant-based and animal foods exert the same health effects due to their various nutrient compositions. We aimed assess quality of v . in relation mortality a prospective cohort study. Using data collected from nationally representative sample 36 825 adults National Health Nutrition Examination Survey 1999–2014, we developed de novo Comprehensive Diet Quality Index ( c DQI) that assesses seventeen based on healthfulness separately scored eleven p six an animal-based DQI)....
DNA methylation markers have been associated with lung cancer risk and may identify aetiologically relevant genomic regions, or alternatively, be of disease factors biological processes development. In a nested case-control study, we measured blood leukocyte levels in pre-diagnostic samples collected from 430 participants (208 cases; 222 controls) the 1989 CLUE II cohort. We compared case/control status to novel both single CpG sites differentially methylated regions (DMRs), while...
Policy Points High-profile international evidence reviews by the World Health Organization, Cancer Research Fund, American Institute for Research, and Society concluded that processed meat consumption increases risk of cancer. The red industries are influential in United States several other nations. US federal government supports public-private partnerships commodity promotion advertising. Four potential policy options to affect taxation, reduced quantities school meal standards, public...
DNA methylation (DNAm) age may reflect age-related variations in biological changes and abnormalities related to ageing. DNAm acceleration measures have been associated with a number of cancers, but our knowledge, not examined relation pancreatic cancer risk or survival. levels leukocytes prediagnostic blood samples 393 cases 431 matched controls, pooled from three large prospective cohort studies, were used estimate age, epigenetic (AA), intrinsic (IEAA) metrics. Logistic regression Cox...
Abstract Background Examining immunity-related DNA methylation alterations in blood could help elucidate the role of immune response lung cancer etiology and aid discovering factors that are key to development progression. In a nested, matched case–control study, we estimated methylation-derived NLR (mdNLR) quantified levels at loci previously linked with circulating concentrations C-reactive protein (CRP). We examined associations between these measures risk survival. Results Using...
Abstract Background Observational studies indicate that periodontal disease may increase the risk of colorectal, lung, and pancreatic cancers. Using a 2-sample Mendelian randomization (MR) analysis, we assessed whether genetic predisposition index for was associated with or cancer risks. Methods Our primary instrument included single nucleotide polymorphisms strong genome-wide association study evidence associations chronic, aggressive, and/or severe (rs729876, rs1537415, rs2738058,...
Abstract Background Epigenome-wide association studies using peripheral blood have identified specific sites of DNA methylation associated with risk various cancers and may hold promise to identify novel biomarkers risk; however, few been performed for pancreatic cancer none a prospective study design. Methods Using nested case-control design, incident cases matched controls were from participants who provided at baseline in 3 cohort studies. levels measured extracted leukocytes the Illumina...
Abstract Background: Pancreatic cancer is projected to become the second most common cause of cancer-related death over next 5 years. Because inflammation thought be a trajectory for disease initiation, we sought prospectively characterize immune profiles using DNA methylation markers and examine levels previously linked biomarkers evaluate whether these play key role in pancreatic cancer. Methods: In nested case–control study pooling three U.S. prospective cohort studies, was measured...
Abstract Background Sugar-sweetened beverage (SSB) consumption contributes to obesity, a risk factor for 13 cancers. Although SSB taxes can reduce intake, the health and economic impact on reducing cancer burdens in United States are unknown, especially among low-income Americans with higher intake obesity-related burdens. Methods We used Diet Cancer Outcome Model, probabilistic cohort state-transition model, project gains benefits of penny-per-ounce national tax obesity-associated cancers...
The 2015 Dietary Guidelines for Americans (DGA) recommend a healthy eating pattern chronic disease prevention. This study aimed to prospectively evaluate diet quality by adherence the DGA in association with mortality outcomes among representative sample of US adults. Using dietary data collected 24-hour recalls 29,098 adults aged 20+ years from National Health and Nutrition Examination Survey (NHANES) 1999 2010, we estimated using Healthy Eating Index-2015 (HEI-2015). Mortality all cause,...
Structured Abstract Background Pancreatic cancer is projected to become the second leading cause of cancer-related death by 2030 in United States. DNA methylation (DNAm) age may reflect age-related variations biological changes and abnormalities related development. Method We conducted a pooled analysis using prediagnostic blood samples pancreatic cases matched controls selected from Nurses’ Health Study (NHS), Physician’s (PHS), Professionals Follow-up (HPFS). used three DNAm aging clocks...
Background Complete pathologic response following neoadjuvant therapy (NAT) for pancreatic ductal adenocarcinoma (PDAC) is rare; alternative markers associated with survival are needed. The aim of this study was to evaluate the impact tumor NAT on overall (OS) in PDAC patients who received and curative-intent surgery. Methods A retrospective utilizing 2006-2018 National Cancer Database identified 6,960 adult NAT. As a comparator group, 15,799 underwent upfront surgical resection were...
Sugar sweetened beverage (SSB) intake is pervasive in the U.S. and a critical risk factor for weight gain obesity. Obesity preventable associated with 13 types of cancers. While SSB taxes can lower intake, potential impact on cancer outcomes, health costs, cost-effectiveness lacking. We aimed to evaluate national tax policy reducing obesity-related used Diet Cancer Outcome Model (DiCOM), probabilistic cohort state-transition model, project effect $0.01 per oz excise obesity-associated...
Abstract Background To reduce lung cancer burden in the US, a better understanding of biological mechanisms early disease development could provide new opportunities for risk stratification. Methods In nested case-control study, we measured blood leukocyte DNA methylation levels pre-diagnostic samples collected from 430 men and women 1989 CLUE II cohort. Median time drawn to diagnosis was 14 years all participants. We compared by case/control status identify novel genomic regions, both...
ABSTRACT Background Examining inflammation-related DNA methylation alterations in blood could help elucidate the role of inflammation lung cancer etiology and aid discovery factors that are key to development progression. In a nested case-control study, we estimated neutrophil-to-lymphocyte ratio using validated index, methylation-derived NLR (mdNLR), quantified levels at loci previously linked with circulating concentrations C-reactive protein (CRP). We examined associations between these...
Meta-analyses have identified obesity as an independent risk factor for 13 cancers and added sugars a contributor to obesity. In 2016, the new Nutrition Facts label on US packaged foods mandated inclusion of sugar content. We assessed health outcomes, costs, cost-effectiveness this policy obesity-related cancer burdens among 250 million adults over their lifetime. populated Diet Cancer Outcome Model (DiCOM), probabilistic cohort-state transitional model, evaluate two effects (a) consumer...
Abstract In 2018, approximately 55,440 individuals were diagnosed with pancreatic cancer in the US, and only 8% of these will survive next five years. Given high fatality rate ductal adenocarcinoma, silent progression this cancer, identifying early detection biomarkers for risk stratification screening surveillance is critical to improve prognosis. While immune response plays a role tumor growth survival, understanding its development has been hampered by lack data on status prior diagnosis....
Background: Many cancer survivors initiated dietary supplement use after diagnosis, and some may supplements at high doses without consulting their healthcare providers.Methods: We evaluated the prevalence, dose, reason of among 3988 adult in National Health Nutrition Examination Survey (NHANES) 1999-2014 compared that to 7770 individuals a history who were matched by age, sex, race/ethnicity.Findings: Compared cancer, reported higher prevalence any (69·9% vs. 63·4%), multivitamin/mineral...