A5075806947- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Neuroblastoma Research and Treatments
- Vascular Tumors and Angiosarcomas
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Neurofibromatosis and Schwannoma Cases
- Metastasis and carcinoma case studies
- COVID-19 Clinical Research Studies
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Soft tissue tumor case studies
- Pancreatitis Pathology and Treatment
- Colorectal and Anal Carcinomas
- Long-Term Effects of COVID-19
- Gallbladder and Bile Duct Disorders
- Cancer Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Economic and Financial Impacts of Cancer
- Cutaneous Melanoma Detection and Management
- Adrenal and Paraganglionic Tumors
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
Brigham and Women's Hospital
2016-2025
Harvard University
2015-2024
Dana-Farber Cancer Institute
2016-2024
Dana-Farber Brigham Cancer Center
2016-2024
Oxford University Hospitals NHS Trust
2021-2023
University of Oxford
2021-2023
Royal Marsden Hospital
2022
National Health and Medical Research Council
2021
Public Health Scotland
2021
Intensive Care National Audit & Research Centre
2021
Retroperitoneal sarcomas (RPS) are rare tumors composed of several well defined histologic subtypes. The aim this study was to analyze patterns recurrence and treatment variations in a large population patients, treated at reference centers.All consecutive patients with primary RPS 6 European 2 North American institutions between January 2002 December 2011 were included. Five, 8, 10-year overall survival (OS) crude cumulative incidence (CCI) local (LR) distant metastasis (DM) calculated....
To investigate the safety of radical resection for retroperitoneal sarcoma (RPS).The surgical management RPS frequently involves complex multivisceral resection. Improved oncologic outcomes have been demonstrated with this approach compared to marginal excision, but has not shown in a large study population.The Transatlantic Retroperitoneal Sarcoma Working Group (TARPSWG) is an international collaborative centers. A combined experience 1007 consecutive resections primary from January 2002...
The aim of the present study was to compare effect radiotherapy (RT) on abdominal recurrence-free survival (ARFS) in patients with primary retroperitoneal sarcoma treated EORTC-STBSG-62092 (STRASS) phase 3 randomized controlled trial (STRASS cohort) and off-trial (STREXIT pool STRASS STREXIT data test hypothesis that RT improves ARFS liposarcoma.The did not show any difference between preoperative radiotherapy+surgery (RT+S) versus surgery alone (S).All consecutive adult enrolled underwent...
Despite a radical surgical approach to primary retroperitoneal sarcoma (RPS), many patients experience locoregional and/or distant recurrence. The objective of this study was analyze post-relapse outcomes for with RPS who had initially undergone resection their tumor at specialist center.All consecutive underwent macroscopically complete 8 high volume centers from January 2002 December 2011 were identified, and those developed local recurrence (LR) only, metastasis (DM) or synchronous...
Abstract Purpose: The role of surgery for first relapse locally recurrent retroperitoneal sarcoma (RPS-LR1) is uncertain. We report outcomes the largest RPS-LR1 series and propose a new prognostic nomogram. Experimental Design: Patients with consecutive without distant metastases who underwent resection at 22 centers (2002–2011) were included. Endpoints disease-free overall survival (DFS, OS) crude-cumulative-incidence (CCI) local/distant recurrence from second surgery. Nomograms predicting...
BACKGROUND A multi‐institutional nomogram for predicting disease‐free survival (DFS) and overall (OS) in patients with primary retroperitoneal sarcoma (RPS) incorporating relevant prognostic factors not included the American Joint Committee on Cancer staging system soft tissue has been reported. The authors validated this an independent, transatlantic cohort. METHODS Data from RPS who were undergoing definitive resection at 1 of 6 centers Europe North America (“validation set”) used to...
The current study investigated the role of radiotherapy (RT) in patients with primary nonmetastatic retroperitoneal liposarcomas.A total 607 localized well-differentiated liposarcomas (WDLPS) and dedifferentiated (DDLPS) underwent surgical resection or without RT at 8 high-volume sarcoma centers (234 WDLPS, 242 grade 1 to 2 DDLPS, 131 3 DDLPS; grading was performed according National Federation Centers for Fight Against Cancer [Federation Nationale des Centres de Lutte Contre le Cancer;...
Neoadjuvant therapy is recommended for locally advanced gastric cancer patients (stage IB-IIIC). The objective of this study to evaluate the accuracy endoscopic ultrasound (EUS) and computed tomography (CT) in identifying with cancer.Patients adenocarcinoma who underwent gastrectomy at our institution were reviewed. Preoperative EUS CT staging compared pathologic determine accuracy.Between 2001 2013, 280 identified. Forty-nine (18%) preoperative by analyzed. individual T stage N was 41.0%...
Objective: To refine treatment recommendations for patients with metastatic gastrointestinal stromal tumors (GISTs) treated tyrosine kinase inhibitors (TKIs) and surgery. Background: Early reports suggested that GIST responding to TKIs surgery may have favorable outcomes. However, identification of prognostic factors was limited by small cohorts. Methods: Progression-free survival (PFS) overall (OS) from time start initial TKI determined. Multivariate analysis conducted on all undergoing...
Objective: Cutaneous radiation therapy (RT)-associated breast angiosarcoma (AS) is a rare consequence of RT associated with poor outcomes. Previous small case series have documented high recurrence rates and survival. We reviewed our experience focused on the impact conservative versus radical resections. Methods: Data for patients RT-associated AS evaluated at institution from 1993 to 2015 who underwent surgery were reviewed. Results: Seventy-six women diagnosed median 85 months invasive...
Background Solitary fibrous tumor (SFT) is a rare mesenchymal malignancy. Although surgery potentially curative, the local relapse risk high after marginal resections. Given lack of prospective clinical trial data, objective current study was to better define role perioperative radiotherapy (RT) in various SFT presentations by location. Methods This retrospective performed across 7 sarcoma centers. Clinical information retrieved from all adult patients with extrameningeal, primary, localized...
In patients with retroperitoneal sarcoma (RPS), the incidence of recurrence after surgery remains high. Novel treatment approaches are needed. This retrospective study evaluated primary, high-risk RPS who received neoadjuvant systemic therapy followed by to 1) determine frequency and potential predictors radiologic tumor responses 2) assess clinical outcomes.Clinicopathologic data were collected for eligible treated at 13 referral centers from 2008 2018. Univariable multivariable logistic...
Background In this series from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG), authors examined longitudinal outcomes of patients with a second recurrence retroperitoneal sarcoma (RPS) after complete resection first local (LR). Methods Data undergoing LR January 2002 to December 2011were collected 22 centers. The primary outcome was overall survival (OS) recurrence. Results Second recurrences occurred in 400 567 (70.5%) an R0/R1 locally recurrent RPS. Patterns...