A5058218845- Sarcoma Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Neuroblastoma Research and Treatments
- Cardiac tumors and thrombi
- Melanoma and MAPK Pathways
- Neurofibromatosis and Schwannoma Cases
- Vascular Tumors and Angiosarcomas
- Nonmelanoma Skin Cancer Studies
- COVID-19 and healthcare impacts
- CAR-T cell therapy research
- Cardiac, Anesthesia and Surgical Outcomes
- Breast Cancer Treatment Studies
- Polyomavirus and related diseases
- Surgical site infection prevention
- Cancer Genomics and Diagnostics
- Gastrointestinal disorders and treatments
- BRCA gene mutations in cancer
- Gastrointestinal Tumor Research and Treatment
- Cancer Cells and Metastasis
- Full-Duplex Wireless Communications
- Trauma and Emergency Care Studies
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Soft tissue tumor case studies
- Global Cancer Incidence and Screening
Ottawa Hospital
2016-2025
Ottawa Hospital Research Institute
2015-2024
University of Ottawa
2017-2024
Alberta Health
2024
BC Cancer Agency
2024
University of British Columbia
2023
Institut de Virologie
2020-2022
McGill University
2022
University of Birmingham
2020
AstraZeneca (Brazil)
2020
Abstract Purpose: The role of surgery for first relapse locally recurrent retroperitoneal sarcoma (RPS-LR1) is uncertain. We report outcomes the largest RPS-LR1 series and propose a new prognostic nomogram. Experimental Design: Patients with consecutive without distant metastases who underwent resection at 22 centers (2002–2011) were included. Endpoints disease-free overall survival (DFS, OS) crude-cumulative-incidence (CCI) local/distant recurrence from second surgery. Nomograms predicting...
Triple‐negative breast cancer ( TNBC ), the most refractory subtype of to current treatments, accounts disproportionately for majority cancer‐related deaths. This is largely due plasticity and development stem cells CSC s). Recently, distinct yet interconvertible mesenchymal‐like epithelial‐like states have been revealed in s. Thus, strategies capable simultaneously inhibiting bulk populations both mesenchymal epithelial be developed. Wnt/β‐catenin Hippo/ YAP pathways are crucial...
Indications for offering adjuvant systemic therapy patients with early-stage melanomas low disease burden sentinel node (SN) micrometastases, namely, American Joint Committee on Cancer (AJCC; eighth edition) stage IIIA disease, are presently controversial. The current study sought to identify high-risk SN-positive AJCC who more likely derive benefit from therapy.Patients were recruited an intercontinental (Australia/Europe/North America) consortium of nine high-volume cancer centers. All...
Background: For patients who are diagnosed with early-stage cutaneous melanoma, the principal therapy is wide surgical excision of primary tumour and assessment lymph nodes. The purpose present guideline was to update 2010 Cancer Care Ontario on local margins sentinel node biopsy (slnb), including treatment positive node, for melanomas trunk, extremities, head neck. Methods: Using Ovid, medline embase electronic databases were systematically searched systematic reviews literature evaluating...
Abstract Triple-negative breast cancer (TNBC) is the most refractory subtype of cancer. It causes majority cancer-related deaths, which has been largely associated with plasticity tumor cells and persistence stem (CSCs). Conventional chemotherapeutics enrich CSCs lead to drug resistance disease relapse. Development a strategy capable inhibiting both bulk CSC populations an unmet medical need. Inhibitors against estrogen receptor 1, HDACs, or mTOR have studied in treatment TNBC; however,...
In patients with retroperitoneal sarcoma (RPS), the incidence of recurrence after surgery remains high. Novel treatment approaches are needed. This retrospective study evaluated primary, high-risk RPS who received neoadjuvant systemic therapy followed by to 1) determine frequency and potential predictors radiologic tumor responses 2) assess clinical outcomes.Clinicopathologic data were collected for eligible treated at 13 referral centers from 2008 2018. Univariable multivariable logistic...
Background In this series from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG), authors examined longitudinal outcomes of patients with a second recurrence retroperitoneal sarcoma (RPS) after complete resection first local (LR). Methods Data undergoing LR January 2002 to December 2011were collected 22 centers. The primary outcome was overall survival (OS) recurrence. Results Second recurrences occurred in 400 567 (70.5%) an R0/R1 locally recurrent RPS. Patterns...
Dermatofibrosarcoma protuberans (DFSP) is a cutaneous sarcoma with an infiltrative growth pattern that makes it challenging to clear margins. High quality data regarding DFSP natural history, management, and outcomes are limited.
Development of targeted therapies for triple‐negative breast cancer ( TNBC , a more aggressive subtype) is an unmet medical need. We analyzed data from 887 patients with invasive and observed that increased Wnt histone deacetylase HDAC ) activities are associated estrogen receptor 1 ESR 1) progesterone PGR repression, poor survival, relapse. The inverse correlation between signaling repression expression was found to be magnified in stem cell CSC subpopulations lines. Cosuppression Wnt,...
Anthracyclines, such as doxorubicin, are used first-line chemotherapeutics, usually in combination therapies, for the treatment of advanced breast cancer. While these drugs have been successful therapeutic options, their use is limited due to serious drug related toxicities and acquired tumor resistance. Uncovering molecular mechanisms that mediate doxorubicin's cytotoxic effect will lead identification novel more efficacious therapies allow reduced doses doxorubicin be administered while...
Melanoma is a type of skin cancer known for its high mortality rate. Cancer stem cells (CSCs) are subpopulation that significantly contribute to tumour recurrence and differentiation. Epigenetic-specific changes involving miRNAs maintain CSCs. Plant polyphenols have been reported be involved in chemoprevention chemotherapy, with being the novel effectors their biological activities. A polyphenol-enriched blueberry preparation (PEBP) derived from fermented blueberries has demonstrated...