A5023506496- Probiotics and Fermented Foods
- Protein Hydrolysis and Bioactive Peptides
- Gut microbiota and health
- Phytochemicals and Antioxidant Activities
- Infant Nutrition and Health
- Antimicrobial Peptides and Activities
- Stress Responses and Cortisol
- Cancer Cells and Metastasis
- Digestive system and related health
- Tryptophan and brain disorders
- Natural Antidiabetic Agents Studies
- Sirtuins and Resveratrol in Medicine
- Metabolism, Diabetes, and Cancer
- Microbial Metabolism and Applications
- Microbial Metabolites in Food Biotechnology
- MicroRNA in disease regulation
- Viral gastroenteritis research and epidemiology
- Diet, Metabolism, and Disease
- Health, psychology, and well-being
- Pharmacological Effects of Natural Compounds
- FOXO transcription factor regulation
- Medicinal Plants and Bioactive Compounds
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- Skin Protection and Aging
University of Ottawa
2015-2024
Université d'Abomey-Calavi
2021
Ontario Brain Institute
2019
uOttawa Brain and Mind Research Institute
2019
Inserm
2011
Université Laval
1996-2010
Université de Moncton
2001-2008
Institut National de la Recherche Scientifique
2007
Université de Montréal
2007
Consejo Nacional de Investigaciones Científicas y Técnicas
2005
Kefir is a fermented milk produced by the action of lactic acid bacteria, yeasts and acetic trapped in complex matrix polysaccharides proteins. Beyond its inherent high nutritional value as source proteins calcium, kefir has long tradition being regarded good for health countries where it staple diet. However, published human or animal feeding trials to substantiate this view are not numerous. The aim work was determine immunomodulating capacity on intestinal mucosal immune response mice...
ABSTRACT The mechanisms by which probiotic bacteria exert their effects on the immune system are not completely understood, but epithelium may be a crucial player in orchestration of induced. In previous work, we observed that some orally administered strains lactic acid (LAB) increased number immunoglobulin A (IgA)-producing cells small intestine without concomitant increase CD4 + T-cell population, indicating LAB induce clonal expansion only B triggered to produce IgA. present work aimed...
Abstract Background A subset of breast cancer cells displays increased ability to self-renew and reproduce heterogeneity. The characterization these so-called putative tumor-initiating (BT-ICs) may open the road for novel therapeutic strategies. As microRNAs (miRNAs) control developmental programs in stem cells, BT-ICs also rely on specific miRNA profiles their sustained activity. To explore notion that miRNAs have a role sustaining BT-ICs, we performed comprehensive profiling expression...
The effect of milks fermented by Lactobacillus helveticus and its non-proteolytic variant on mucosal tumoral immunity was studied. Milks Lb. wild type or were administered orally to mice for different periods (3, 5 7 d). immune response assessed analysing the activity peritoneal macrophages, number cells secreting IgA associated with gut-associated lymphoid tissue bronchial-associated tissue. determined direct immunofluorescence. antitumour monitored studying regression subcutaneously...
Abstract Introduction Antitumour activity is one of the health-promoting effects attributed to lactic acid bacteria and their products fermentation. Previous studies in mice demonstrated that bioactive compounds released milk fermented by Lactobacillus helveticus R389 contribute its immunoenhancing antitumour properties. The aim present work was study consumption L. or proteolytic-deficient variant, L89, on a murine hormone-dependent breast cancer model. Methods Mice were fed with during 2 7...
ABSTRACT Numerous beneficial effects have been attributed to probiotic lactic acid bacteria (LAB), such as the stimulation of immune system, prevention enteric infections by enteropathogens, and regression immunodependent tumors. It has shown that biologically active metabolites released during fermentation, in particular biopeptides, could act immunomodulatory agents. However, no studies conducted evaluate implication these bioactive peptides induction a protective response against...
AbstractGrowing evidence supports the existence of a subpopulation cancer cells with stem cell characteristics within breast tumors. In spite its potential clinical implications, an understanding mechanisms responsible for retaining in these is still lacking. Here, we used mammosphere model combined DNA methylation bead arrays and quantitative gene expression to characterize epigenetic involved regulation developmental pathways putative cells. Our results revealed that MCF7-derived...
Naturally occurring polyphenolic compounds from fruits, particularly blueberries, have been reported to be significantly involved in cancer chemoprevention and chemotherapy. Biotransformation of blueberry juice by Serratia vaccinii increases its content endows it with anti-inflammatory properties. This study evaluated the effect a polyphenol-enriched preparation (PEBP) non-fermented counterpart (NBJ), on mammary stem cell (CSC) development vitro, vivo ex settings. Effects PEBP proliferation,...