A5045420009- Stress Responses and Cortisol
- Gut microbiota and health
- Cancer Cells and Metastasis
- Agriculture and Rural Development Research
- Tryptophan and brain disorders
- Probiotics and Fermented Foods
- Viral gastroenteritis research and epidemiology
- Hypothalamic control of reproductive hormones
- Immune Response and Inflammation
- Pharmacology and Obesity Treatment
- Therapeutic Uses of Natural Elements
- Diet and metabolism studies
- Muscle Physiology and Disorders
- Pharmacological Effects and Toxicity Studies
- Antimicrobial Peptides and Activities
- Medicinal Plants and Bioactive Compounds
- Planarian Biology and Electrostimulation
- Health, psychology, and well-being
- Pain Management and Treatment
- Autoimmune Bullous Skin Diseases
- PI3K/AKT/mTOR signaling in cancer
- Mycorrhizal Fungi and Plant Interactions
- Seaweed-derived Bioactive Compounds
- Sarcoma Diagnosis and Treatment
- Chemical Reactions and Isotopes
University of Ottawa
2013-2023
University of Colorado Anschutz Medical Campus
1992
Naturally occurring polyphenolic compounds from fruits, particularly blueberries, have been reported to be significantly involved in cancer chemoprevention and chemotherapy. Biotransformation of blueberry juice by Serratia vaccinii increases its content endows it with anti-inflammatory properties. This study evaluated the effect a polyphenol-enriched preparation (PEBP) non-fermented counterpart (NBJ), on mammary stem cell (CSC) development vitro, vivo ex settings. Effects PEBP proliferation,...
Abstract Puberty is a critical developmental period that characterized by significant brain development. Exposure to stress during this time can alter functioning setting the stage for long‐lasting behavioural outcomes. The objective of study was investigate age and sex differences in peripheral central immune responses, along with sickness behaviour, following stress. results showed LPS treatment increased serum cytokine levels symptoms all mice. Pubertal males displayed IL‐1β...
Epigenetic mechanisms such as microRNA (miRNA) deregulation seem to exert a central role in breast cancer initiation and progression. Therefore, targeting epigenetics may be an effective strategy for preventing halting carcinogenesis. Studies have revealed the significant of naturally occurring polyphenolic compounds derived from fermented blueberry fruits chemoprevention by modulation stem cell development through epigenetic mechanism regulation cellular signaling pathways. In this study,...
Exposure of the skin to solar UV radiation leads inflammation, DNA damage, and dysregulation cellular signaling pathways, which may cause cancer. Photochemoprevention with natural products is an effective strategy for control cutaneous neoplasia. Polyphenols have been proven help prevent cancer inhibit growth stem cells (CSCs) through epigenetic mechanisms, including modulation microRNAs expression. Thus, current study aimed assess effect polyphenol enriched blueberry preparation (PEBP) or...
Scientific evidence supports the early deregulation of epigenetic profiles during breast carcinogenesis. Research shows that cellular transformation, carcinogenesis, and stemness maintenance are regulated by epigenetic-specific changes involve microRNAs (miRNAs). Dietary bioactive compounds such as blueberry polyphenols may modulate susceptibility to cancer modulation CSC survival self-renewal pathways through mechanism, including regulation miRNA expression. Therefore, current study aimed...
The PacBio whole-genome sequencing of the potential probiotic strain Canan SV-53T recovered from lowbush blueberries demonstrates high homology to Rouxiella badensis but with distinct enough clusters propose name subsp. acadiensis. also detected presence two native plasmids.
Many breast cancer patients use natural compounds in their battle against cancer. Active Hexose Correlated Compound (AHCC®) is a cultured mushroom mycelium extract shown to favorably modulate the immune system and alleviate burden. Cancer Stem cells (CSCs) are subset of highly tumorigenic that thought be responsible for recurrence. CSCs can epigenetically regulated by microRNAs (miRNAs). We hypothesized AHCC may influence modulating tumor-suppressor or oncogenic miRNAs.
Gut immune system homeostasis is crucial to overall host health. Immune disturbance at the gut level may lead systemic and distant sites’ dysfunction. Probiotics prebiotics consumption have been shown improve microbiota composition function enhance immunity. In current study, immunomodulatory anti-inflammatory effects of viable heat-inactivated forms novel probiotic bacterium Rouxiella badensis subsp. acadiensis (Canan SV-53), as well prebiotic protocatechuic acid (PCA) derived from...
Puberty is a critical period of development marked by sexual, immune, and neural maturation. Exposure to stress during this can lead enduring changes in brain functioning behavior; however, the underlying mechanisms programming effects puberty remain unknown. Therefore, objective study was investigate pubertal immune challenge response homotypic stressor later life CD-1 mice. Age sex differences peripheral central cytokine levels, along with sickness behavior telemetry data, were analyzed...
Active Hexose Correlated Compound (AHCC ® ) is a fermented mushroom extract that commercially available and promoted for immune support. Available data suggest AHCC supplementation clearly affects outcomes cell populations, endowing it with potent anti‐inflammatory effects. The mechanism by which exert its effects not well understood yet. present work aimed to analyze the immunomodulatory activity of in gut, study role Intestinal Epithelial Cells (IECs) TLRs signaling. BALC/c mice were fed...