A5041631891- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- Cancer Treatment and Pharmacology
- Health Systems, Economic Evaluations, Quality of Life
- Reconstructive Surgery and Microvascular Techniques
- Economic and Financial Impacts of Cancer
- Advanced Breast Cancer Therapies
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- Radiomics and Machine Learning in Medical Imaging
- BRCA gene mutations in cancer
- Medical Imaging Techniques and Applications
- Ethics in Clinical Research
- Clinical practice guidelines implementation
- Advances in Oncology and Radiotherapy
- Cancer survivorship and care
- Ferroptosis and cancer prognosis
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- MRI in cancer diagnosis
Ottawa Hospital
2016-2025
Ottawa Hospital Research Institute
2015-2024
Institute of Cancer Research
2023-2024
Provincial Health Services Authority
2024
University of Ottawa
2013-2022
Weatherford College
2022
Creative Commons
2018-2021
Canadian Partnership Against Cancer
2021
Institute for Clinical Evaluative Sciences
2015-2020
Curtin University
2020
Purpose An increasing proportion of patients (> 30%) with node-positive breast cancer will obtain an axillary pathologic complete response after neoadjuvant chemotherapy (NAC). If sentinel node (SN) biopsy (SNB) is accurate in this setting, completion dissection (CND) morbidity could be avoided. Patients and Methods In the prospective multicentric SN FNAC study, biopsy-proven (T0-3, N1-2) underwent both SNB CND. Immunohistochemistry (IHC) use was mandatory, metastases any size, including...
PURPOSE Patients with locally advanced breast cancer (LABC) typically undergo staging tests at presentation. If does not detect metastases, treatment consists of curative intent combined modality therapy (neoadjuvant chemotherapy, surgery, and regional radiation). Positron emission tomography-computed tomography (PET-CT) may more asymptomatic distant but the evidence is based on uncontrolled studies. METHODS For inclusion, patients had histological invasive ductal carcinoma TNM stage III or...
Triple‐negative breast cancer ( TNBC ), the most refractory subtype of to current treatments, accounts disproportionately for majority cancer‐related deaths. This is largely due plasticity and development stem cells CSC s). Recently, distinct yet interconvertible mesenchymal‐like epithelial‐like states have been revealed in s. Thus, strategies capable simultaneously inhibiting bulk populations both mesenchymal epithelial be developed. Wnt/β‐catenin Hippo/ YAP pathways are crucial...
Despite growing interest in using large language models (LLMs) healthcare, current explorations do not assess the real-world utility and safety of LLMs clinical settings. Our objective was to determine whether two can serve information needs submitted by physicians as questions an informatics consultation service a safe concordant manner. Sixty six from consult were GPT-3.5 GPT-4 via simple prompts. 12 assessed LLM responses' possibility patient harm concordance with existing reports...
Estrogen drives both transcriptional activation and proteolysis of estrogen receptor alpha (ER alpha; encoded by ESR1). Here we observed variable overlapping ESR1 mRNA levels in 200 ER alpha-negative 50 alpha-positive primary breast cancers examined, which suggests important posttranscriptional regulation. Our results indicate that Src cooperates with to activate proteolysis. Inducible stimulated ligand-activated activity reduced t(1/2). were inversely correlated cancers. cell lines showed...
<h3>Importance</h3> Contrary to practice guidelines, breast magnetic resonance imaging (MRI) is commonly used in the preoperative evaluation of women with cancer. While existing literature has found little benefit MRI most patients, potential downstream consequences associated are not well described. <h3>Objective</h3> To describe patterns utilization a health care system universal insurance and its association investigations clinical outcomes. <h3>Design, Setting, Participants</h3> This was...
Abstract Triple-negative breast cancer (TNBC) is the most refractory subtype of cancer. It causes majority cancer-related deaths, which has been largely associated with plasticity tumor cells and persistence stem (CSCs). Conventional chemotherapeutics enrich CSCs lead to drug resistance disease relapse. Development a strategy capable inhibiting both bulk CSC populations an unmet medical need. Inhibitors against estrogen receptor 1, HDACs, or mTOR have studied in treatment TNBC; however,...
Practice guidelines recommend that imaging to detect metastatic disease not be performed in the majority of patients with early-stage breast cancer who are asymptomatic. We aimed determine whether practice patterns Ontario conform these recommendations.We used provincial registry data identify a population-based cohort women whom early-stage, operable was diagnosed between 2007 and 2012. then determined skeleton, thorax, abdomen or pelvis had been within 3 months tissue diagnosis. calculated...
The probability of detecting radiologically evident metastatic disease in asymptomatic women with newly diagnosed operable breast cancer is low. Despite the recommendations most practice guidelines imaging still frequently performed. Relatively little known about what patients believe important when it comes to radiologic staging.Patients early stage who had completed their definitive surgery were surveyed personal experiences, perceptions, and expectations on issue perioperative for distant...
Development of targeted therapies for triple‐negative breast cancer ( TNBC , a more aggressive subtype) is an unmet medical need. We analyzed data from 887 patients with invasive and observed that increased Wnt histone deacetylase HDAC ) activities are associated estrogen receptor 1 ESR 1) progesterone PGR repression, poor survival, relapse. The inverse correlation between signaling repression expression was found to be magnified in stem cell CSC subpopulations lines. Cosuppression Wnt,...
The current clinical trials development and conduct process is cumbersome expensive, with the majority of studies focusing on either new agents or indications for established agents. Unfortunately, research comparing standard-of-care interventions rarely performed, leaving many important practical patient-centered questions unanswered. Novel trial methodologies approaches are needed.We have identified simple key components that, when combined, enhance ability to both perform increase accrual...
Despite multiple guidelines advocating against routine radiological evaluation for metastases in women with early stage breast cancer, imaging is still frequently overused. The objective of this study was to assess doctor's views on guidelines, and an attempt establish why personal local clinical practice patterns regarding may differ from current guidelines.Canadian doctors who treat cancer were invited by email complete online survey developed members the research team.Responses received...