A5019124641- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Alcohol Consumption and Health Effects
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Drug Transport and Resistance Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Ginseng Biological Effects and Applications
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Diet and metabolism studies
- Traditional Chinese Medicine Analysis
- Berberine and alkaloids research
- Endoplasmic Reticulum Stress and Disease
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Liver Disease and Transplantation
- RNA modifications and cancer
- Cancer-related gene regulation
- Liver physiology and pathology
- Liver Diseases and Immunity
Shanghai University of Traditional Chinese Medicine
2016-2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2025
Nanjing University of Chinese Medicine
2025
Jiangsu Province Hospital
2025
Minhang District Central Hospital
2023
Fudan University
2023
Wenzhou Medical University
2010-2021
First Affiliated Hospital of Wenzhou Medical University
2010-2021
Soochow University
2020
Multidrug resistance is a major challenge to cancer chemotherapy. The multidrug phenotype associated with the overexpression of adenosine triphosphate (ATP)-driven transmembrane efflux pumps in cells. Here, we report lipid membrane-coated silica-carbon (LSC) hybrid nanoparticle that targets mitochondria through pyruvate, specifically produce reactive oxygen species (ROS) under near-infrared (NIR) laser irradiation. ROS can oxidize NADH into NAD+ reduce amount ATP available for pumps....
One of the primary mechanisms tumor cell immune evasion is loss antigenicity, which arises due to lack immunogenic antigens as well dysregulation antigen processing machinery. In a screen for small-molecule compounds from herbal medicine that potentiate T cell-mediated cytotoxicity, we identified atractylenolide I (ATT-I), substantially promotes presentation both human and mouse colorectal cancer (CRC) cells thereby enhances cytotoxic response CD8+ cells. Cellular thermal shift assay (CETSA)...
Non-alcoholic fatty liver disease (NAFLD) is regarded as a pandemic that affects about quarter of the global population. Recently, host-gut microbiota metabolic interactions have emerged distinct mechanistic pathways implicated in development NAFLD. Here, we report group gut microbiota-modified bile acids (BAs), hyodeoxycholic acid (HDCA) species, are negatively correlated with presence and severity HDCA treatment has been shown to alleviate NAFLD multiple mouse models by inhibiting...
Abstract Gut dysbiosis has been linked to type 1 diabetes (T1D); however, microbial capacity in T1D remains unclear. Here, we integratively profiled gut functional and metabolic alterations children with new-onset independent cohorts investigated the underlying mechanisms. In T1D, microbiota was characterized by decreased butyrate production bile acid metabolism increased lipopolysaccharide biosynthesis at species, gene, metabolite levels. The combination of 18 bacterial species fecal...
Abstract Background Circular RNAs (circRNAs), important members of the noncoding RNA family, have been recently revealed to play a role in pathogenic progression diseases, particularly malignant cancer. With application high-throughput sequencing technology, large number circRNAs identified tumor tissues, and some demonstrated act as oncogenes. In this study, we analyzed circRNA expression profile colorectal cancer (CRC) tissues normal adjacent by sequencing. We focused on circRNA_0000392,...
Hyperlipidemia is a major component of metabolic syndrome, and often predicts cardiovascular diseases. We developed new therapeutic agent berberine compounds (BC), consisting berberine, oryzanol vitamin B6, determined their anti-hyperlipidemia activity underlying mechanisms. Male Wistar rats were fed high fat diet (HFD) to induce hyperlipidemia, then given BC orally for 4 weeks. Body weight food intake recorded weekly, lipid profiles in serum biochemically. Metabolites serum, urine, liver...
Abstract Dysregulated energetic metabolism has been recently identified as a hallmark of cancer. Although mutations in metabolic enzymes hardwire to tumourigenesis, they are relatively infrequent ovarian More often, cancer is re-engineered by altered abundance and activity the enzymes. Here we identify ubiquitin-specific peptidase 13 (USP13) master regulator that drives metabolism. USP13 specifically deubiquitinates thus upregulates ATP citrate lyase oxoglutarate dehydrogenase, two key...
The concept of "network target" has ushered in a new era the field traditional Chinese medicine (TCM). As research approach, network pharmacology is based on analysis models and systems biology. Taking advantage advancements biology, high degree integration data strategy interpretable visualization provides deeper insights into underlying mechanisms TCM theories, including principles herb combination, biological foundations or herbal formulae action, molecular basis syndromes. In this study,...
Abstract Stromal cells, infiltrating immune paracrine factors and extracellular matrix have been extensively studied in cancers. However, autocrine produced by tumor cells communications between intracellular signaling pathways the development of drug resistance, cancer stem-like (CSCs) tumorigenesis not well investigated, precise mechanism tangible approaches remain elusive. Here we reveal a new which cytokines breast after chemotherapy withdrawal activate both Wnt/ β -catenin NF- κ B...
Colorectal carcinoma (CRC) is the third most common cancer and second cause of cancer-related deaths worldwide. Ribonucleic acid (RNA) N6-methyladnosine (m6A) methyltransferase-like 3 (METTL3) play key roles in progression. However, m6A METTL3 CRC progression require further clarification.Adenoma samples were examined to detect levels, tissue microarrays performed evaluate association levels with survival patients CRC. The biological functions investigated through cell counting kit-8, wound...
Hesperidin, a naturally occurring flavonoid presents in fruits and vegetables, has been reported to exert wide range of pharmacological effects that include antioxidant, anti-inflammatory, antihypercholesterolemic, anticarcinogenic actions. However, the cytoprotection mechanism hesperidin neutralize oxidative stress human hepatic L02 cells remain unclear. In this work, we assessed capability attenuate hydrogen peroxide (H2O2)-induced cell damage by augmenting cellular antioxidant defense....