A5100760363- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- Ginseng Biological Effects and Applications
- Liver Diseases and Immunity
- Berberine and alkaloids research
- Liver Disease and Transplantation
- Eicosanoids and Hypertension Pharmacology
- Drug-Induced Hepatotoxicity and Protection
- Medicinal plant effects and applications
- Magnolia and Illicium research
- Melanoma and MAPK Pathways
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Phytochemistry and Bioactive Compounds
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Kruppel-like factors research
- Cannabis and Cannabinoid Research
- Inflammatory Bowel Disease
- Fibroblast Growth Factor Research
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2011-2024
Shanghai University of Traditional Chinese Medicine
2013-2024
Gansu University of Traditional Chinese Medicine
2024
University at Buffalo, State University of New York
2018
Women & Children's Hospital of Buffalo
2018
National Clinical Research Center for Digestive Diseases
2016
Icahn School of Medicine at Mount Sinai
2011-2012
Hyperlipidemia is a major component of metabolic syndrome, and often predicts cardiovascular diseases. We developed new therapeutic agent berberine compounds (BC), consisting berberine, oryzanol vitamin B6, determined their anti-hyperlipidemia activity underlying mechanisms. Male Wistar rats were fed high fat diet (HFD) to induce hyperlipidemia, then given BC orally for 4 weeks. Body weight food intake recorded weekly, lipid profiles in serum biochemically. Metabolites serum, urine, liver...
Aim. To assess the efficacy of berberine in treatment nonalcoholic fatty liver disease through meta-analysis. Method. We searched Embase, Pubmed, Cochrane Library, and so forth, until March 2016 for randomized controlled trials using to treat NAFLD. Result. Six involving 501 patients were included this study. The results showed that reducing TC, LDL, ALT, 2hPG, HbA1c NAFLD group significantly higher than control group. subgroup analyses on TG, AST, FBG indicated combined with decreased TG...
Non-alcoholic fatty liver disease (NAFLD) has become one of the main chronic diseases worldwide. Protopanaxadiol (PPD), an active compound derived from Gynostemma pentaphyllum, been found able to improve free acid-induced lipid accumulation in hepatocytes. However, efficacy PPD on NAFLD and underlying mechanism remains unknown. In this study, mice were fed with a high-fat diet for 22 weeks induce model, then treated by gavage 8 weeks. Moreover, AML12 HepG2 cells induced acids 24 h, different...
Alzheimer's disease (AD)-related brain deterioration is linked to the type 2 diabetes mellitus (T2DM) features hyperglycemia, hyperinsulinemia, and insulin resistance. Hypoxia as a common risk factor for both AD T2DM. Hypoxia-inducible factor-1 alpha (HIF-1α) acts main regulator of hypoxia response may be key target in comorbidity HIF-1α expression closely related resistance, inflammation. Tissue oxygen consumption disrupts homeostasis, leading increased reactive species levels inhibition...
The activated c-Jun N-terminal kinase (JNK) specifically combined with SH3 domain-binding protein 5 (Sab) may mediate damage to the mitochondrial respiratory chain. Whether dysfunction induced by JNK/Sab signaling pathway plays a pivotal role in lipotoxic injury of nonalcoholic steatohepatitis (NASH) remains lack evidence. Scoparone, natural compound from Traditional Chinese Medicine herbs, has potential for liver protection and lipid metabolism regulation. However, effect scoparone on NASH...
We aim to identify the differences in colonic mucosal transcriptome between Crohn's disease (CD) and ulcerative colitis (UC) for a better understanding of molecular pathology. Differentially expressed genes (DEG) mucosa CD UC were identified with global gene expression microarray dataset generated from colon biopsies patients normal controls. The DEGs then processed altered pathways modularized pathways. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis an independent...
Abstract To enhance our understanding of molecular mechanisms and mine novel biomarkers non-alcoholic fatty liver disease (NAFLD), RNA sequencing was performed to gain hepatic expression profiles mRNAs miRNAs in NAFLD normal rats. Using DESeq with thresholds a two-fold change false discovery rate (FDR) less than 0.05, 336 21 were identified as differentially expressed. Among those, 17 (e.g., miR-144-3p, miR-99a-3p, miR-200b-3p, miR-200b-5p, miR-200c-3p, etc .) might serve NAFLD. MiRNA target...
Lingguizhugan decoction (LGZG), a classic traditional Chinese medicine (TCM) formula, has been used to treat obesity and hyperlipidemia in recent years, but the related mechanisms underlying regulation of lipid metabolism by LGZG are not clear yet. Here, we reported effectiveness possible on rats with fatty liver disease induced high-fat diet (HFD). Our results demonstrated that significantly attenuated HFD-induced disease, as measured body weight, index, epididymal fat pad-body weight ratio...
Lingguizhugan decoction, a classic traditional Chinese medicine formula, has been used to treat non-alcoholic fatty liver disease (NAFLD), however, the underlying mechanisms remains unclear. In present study, we compared phenotype of normal rats (fed with chow diet), high-fat-diet (HFD) induced NAFLD and decoction (LGZG, comprises four herbs: Poria, Ramulus Cinnamomi, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae.) intervened rats, detected whole genome gene expression by RNA-Seq....
Abstract Background Salvia-Nelumbinis naturalis (SNN), the extract of Chinese herbal medicine, has shown effects on NAFLD. This study aims to explore underlying mechanism SNN for regulating lipid metabolism disorder in NAFLD based SIRT1/AMPK signaling pathway. Methods Male C57BL/6J mice fed with a high-fat diet (HFD) were used establish model. Dynamic changes including body weight, liver serological biochemical indexes, histopathological changes, and protein level AMPK SIRT1 monitored....
Background . Nonalcoholic fatty liver disease (NAFLD) has become a leading cause of transplantation. Lingguizhugan decoction (LGZG), classical Chinese herbal formula, beneficial effects on NAFLD animal models. Our study examined the impact LGZG hepatic global transcriptome high-fat-diet-induced rats. Methods Three groups Wistar rats were included: normal, model, and LGZG-treated groups. Four weeks for treatment, tissues harvested RNA sequencing. Differentially expressed genes (DEGs) enriched...
Cytochrome P450 2E1 (CYP2E1) induction and tumor necrosis factor alpha (TNF-α) production are key risk factors in alcoholic liver injury. Increased oxidative stress from CYP2E1 by pyrazole vivo sensitizes the to TNF-α-induced hepatotoxicity a mechanism involving activation of c-jun N-terminal kinase (JNK) mitochondrial damage. The aim this study was evaluate whether JNK1 or JNK2 plays role potentiated hepatotoxicity. Wild-type (WT), jnk1(-/-) , jnk2(-/-) mice were used identify changes...
Non-alcoholic fatty liver disease (NAFLD) may increase the sensitivity to injury caused by stimulants such as drugs and poisons. The traditional Chinese medicine (TCM) Jiang-Zhi Granule (JZG) has been proven effective for improving function, reducing hepatic fat accumulation inflammation in NAFLD. purpose of this study is evaluate effect JZG on susceptibility NAFLD rats identify relevant mechanism. Forty wistar were randomly divided into five groups, normal group, normal+CCl4 high-fat diet...
The prevalence of type 2 diabetes continuously increases globally. traditional Chinese medicine (TCM) can stratify the diabetic patients based on their different TCM syndromes and, thus, allow a personalized treatment. Metabolomics is able to provide metabolite biomarkers for disease subtypes. In this study, we applied metabolomics approach using an ultraperformance liquid chromatography (UPLC) coupled with quadruple-time-of-flight (QTOF) mass spectrometry system characterize metabolic...
To test whether nonalcoholic hepatic steatosis sensitizes carbon tetrachloride (CCl4)-induced liver injury, and to assess the therapeutic effect of Chinese medicine extracts Dangfei Liganning capsules () their potential underlying mechanisms. Male Wistar rats were fed a high-fat diet induce fatty disease (NAFLD) or normal (N). Eight weeks later, nonlethal dose CCl4 was applied intraperitoneally. From start, HF-CCl4 administered daily Dangyao (D), (DF), Diammonium Glycyrrhizinate (G)...
The extract of Marsdenia tenacissima (Roxb.) Moon [Apocynaceae] (MTE) has shown a significant anti-cancer effect on hepatocellular carcinoma (HCC), but its mechanism remains unclear. In this study, we used transcriptomics methods to investigate the underlying MTE against HCC. Both MHCC97H and HepG2 cell lines were treated with MTE. viability migration measured using counting kit-8 assay transwell assay. RNA-sequencing was identify differentially expressed genes (DEGs) between cells without...
There is still a lack of effective therapeutic drugs for nonalcoholic fatty liver disease (NAFLD) to date. In this study, we applied mouse model experiments clarify the effect Chinese herbal medicine "Lanzhang Granules (LZG)" on NAFLD and further explore potential mechanism provide an alternative method treatment.Male C57BL/6J mice were fed with high-fat diet (HFD) twenty-two weeks induce model. LZG intervention was then performed by gavage daily another eight weeks. At end treatment, serum...