A5100631972- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Neuropeptides and Animal Physiology
- Pain Management and Placebo Effect
- Pancreatic and Hepatic Oncology Research
- Musculoskeletal pain and rehabilitation
- Neuroscience and Neuropharmacology Research
- Acupuncture Treatment Research Studies
- Pancreatitis Pathology and Treatment
- Orthopaedic implants and arthroplasty
- Nerve injury and regeneration
- Orthopedic Infections and Treatments
- Biochemical Analysis and Sensing Techniques
- Dietary Effects on Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Cellular Mechanics and Interactions
- Neurobiology and Insect Physiology Research
- Peripheral Nerve Disorders
- Alzheimer's disease research and treatments
- Total Knee Arthroplasty Outcomes
- Management of metastatic bone disease
- Gut microbiota and health
- Ion channel regulation and function
- Healthcare and Venom Research
- Pancreatic function and diabetes
Shaanxi University of Science and Technology
2022-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015-2024
Chongqing Medical University
2015-2024
Gansu University of Traditional Chinese Medicine
2024
Qujing Normal University
2022-2023
Nanjing University
2016-2022
Zhongda Hospital Southeast University
2015-2022
United States Food and Drug Administration
2022
Tokyo Metropolitan University
2015-2020
Soochow University
2014-2020
The emerging literature implicates a role for glia/cytokines in persistent pain. However, the mechanisms by which these non-neural elements contribute to CNS activity-dependent plasticity and pain are unclear. Using trigeminal model of inflammatory hyperalgesia, here we provide evidence that demonstrates mechanism glia interact with neurons, leading hyperalgesia. In response masseter inflammation, there was an upregulation glial fibrillary acidic proteins (GFAPs), marker astroglia,...
Spinal glial reaction and proinflammatory cytokine induction play an important role in the development of chronic pain states after tissue nerve injury. The present study investigated cellular molecular mechanisms underlying descending facilitation neuropathic with emphasis on supraspinal glial–neuronal relationships. An early transient microglia prolonged astrocytes were found constriction injury (CCI) rat infraorbital rostral ventromedial medulla (RVM), a major component brainstem...
Hindpaw inflammation induces tyrosine phosphorylation (tyr-P) of the NMDA receptor (NMDAR) 2B (NR2B) subunit in rat spinal dorsal horn that is closely related to initiation and development hyperalgesia. Here, we show rats with Freund's adjuvant-induced inflammation, increased NR2B tyr-P blocked by group I metabotropic glutamate (mGluR) antagonists [7-(hydroxyimino)cyclopropa[b] chromen-1a-carboxylate ethyl ester (CPCCOEt) 2-methyl-6-(phenylethynyl)-pyridine (MPEP), Src inhibitor CGP 77675,...
Abstract The roots of Scutellaria baicalensis has been used as a remedy for inflammatory and infective diseases thousands years. We evaluated the antiviral activity against respiratory syncytial virus (RSV) infection, leading cause childhood infection hospitalization. By fractionation chromatographic analysis, we determined that baicalin was responsible S. RSV infection. concentration 50% inhibition (IC 50 ) at 19.9 ± 1.8 μM, while cytotoxic (CC measured 370 10 μM. then mouse model to...
Alzheimer's disease (AD)-related brain deterioration is linked to the type 2 diabetes mellitus (T2DM) features hyperglycemia, hyperinsulinemia, and insulin resistance. Hypoxia as a common risk factor for both AD T2DM. Hypoxia-inducible factor-1 alpha (HIF-1α) acts main regulator of hypoxia response may be key target in comorbidity HIF-1α expression closely related resistance, inflammation. Tissue oxygen consumption disrupts homeostasis, leading increased reactive species levels inhibition...
Peripheral nerve injury produces signs of neuropathic pain including tactile allodynia and thermal hyperalgesia, sensory modalities which may be associated with different neuronal pathways. Studies spinally-transected, nerve-injured rats have led to suggestions that hyperalgesia mediated predominately through local spinal circuitry whereas ascending input supraspinal sites is critical the manifestation allodynia. Here, nature mediating was explored using selective lesions. Male...
Sweet taste and nonnutritive suckling produce analgesia to transient noxious stimuli in infant rats humans. The present study evaluated the pain-modulating effects of sucrose a rat model persistent pain hyperalgesia that mimics response tissue injury Fore- hindpaw withdrawal latencies from 30 degrees or 48 C brass stylus were determined 10-day-old following paw inflammation induced by complete Freund's adjuvant (CFA; 1:1 injected s.c. 0.01 ml volume). CFA markedly decreased escape both...
1. Supraspinal relays for vagal afferent modulation of responses spinal dorsal horn neurons to 50 degrees C heating the skin were examined by use nonselective, reversible local anesthesia or soma-selective, irreversible neurotoxic damage neural tissue. Eighty-five isolated in lumbar 80 pentobarbital-anesthetized, paralyzed rats. All studied had receptive fields on glabrous plantar surface ipsilateral hind paw and responded mechanical stimuli both low high intensity as well noxious thermal...
Brain stem descending pathways modulate spinal nociceptive transmission. In a lightly anesthetized rat preparation, we present evidence that such modulation undergoes time-dependent changes following persistent hindpaw inflammation. There was an initial decrease and subsequent increase in the excitability of neurons rostral ventromedial medulla (RVM) involving facilitation inhibition. These were most robust after stimulation inflamed paw although similar findings seen on non-inflamed tail....
The anticonvulsant gabapentin (GBP) has been shown effective for the treatment of neuropathic pain, although its mechanism action remains unclear. A recent report suggested that binding to α<sub>2</sub>δ subunit voltage-gated calcium channels contributes antinociceptive effect, based on stereoselective efficacy two analogs: (1<i>S</i>,3<i>R</i>)3-methylgabapentin (3-MeGBP) (IC<sub>50</sub> = 42 nM), which is in pain models; and (1<i>R</i>,3<i>R</i>)3-MeGBP > 10,000 ineffective (Field et...
Wear particle-induced inflammation is considered to be the major cause of aseptic implant loosening and clinical failure after total joint replacement. Due frequent absence symptoms, early detection intervention prior presents a significant challenge. To address this issue, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-based optical imaging contrast agent (P-IRDye) was developed used for wear employing murine calvaria osteolysis model. The evaluated by H&E, tartrate-resistant acid...
ABSTRACT Two steroids ( 1 , 2 ) and four steroid sulfates 3 – 6 were isolated from the sponge Topsentia sp. collected South China Sea. The structures of these compounds determined based on spectroscopic methods comparison with reported data. Compound 5 was for first time title sponge. Compounds 4 concentration‐dependently inhibited spontaneous synchronized Ca 2+ oscillations (SCOs) 4‐aminopyridine (4‐AP) ‐induced epileptic discharges in primary cultured cortical neuronal networks....
The effects of spinal transection on Fos protein expression following complete Freund's adjuvant-induced hindpaw inflammation and hyperalgesia were studied. Fos-like immunoreactivity (LI) was used as a measure neuronal activity in dorsal horn nociceptive pathways. Induction Fos-LI spinally transected rats with 3 days significantly increased ipsilateral lumbar (L 4,5) cord, when compared control animals similar but an intact cord. contralateral side also showed significant induction to the...
Focal adhesion kinase (FAK) has been implicated in tumorigenesis various malignancies. We sought to examine the expression patterns of FAK and activated form, phosphorylated (pFAK), human osteosarcoma investigate correlation with clinicopathologic parameters prognosis. In addition, functional consequence manipulating protein level was investigated cell lines. Immunohistochemical staining used detect pFAK pathologic archived materials from 113 patients primary osteosarcoma. Kaplan-Meier...