A5056007719- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Urinary and Genital Oncology Studies
- MicroRNA in disease regulation
- Prostate Cancer Treatment and Research
- Extracellular vesicles in disease
- Prostate Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Pelvic floor disorders treatments
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Hormonal and reproductive studies
- Cancer-related gene regulation
- Ureteral procedures and complications
- Cancer Mechanisms and Therapy
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Spine and Intervertebral Disc Pathology
- Cell death mechanisms and regulation
Guangxi University
2025
Guangxi University of Chinese Medicine
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015-2024
Chongqing Medical University
2015-2024
Chongqing University
2024
Peking University People's Hospital
2024
Peking University
2024
Chongqing Institute of Green and Intelligent Technology
2024
Chengdu University of Traditional Chinese Medicine
2024
First People's Hospital of Chongqing
2024
Although it is known that tumor necrosis factor-related apoptosis-inducing ligand (TNFSF10/TRAIL) induces autophagy, the mechanism by which autophagy activated TNFSF10 still elusive. In this report, we show evidence TRAF2- and RIPK1-mediated MAPK8/JNK activation required for TNFSF10-induced cytoprotective autophagy. rapidly in cancer cell lines derived from lung, bladder prostate tumors. Blocking with either pharmacological inhibitors or siRNAs targeting key factors BECN1/Beclin 1 ATG7...
Renal ischemia/reperfusion (I/R) injury is the main reason for acute kidney (AKI) and closely related to high morbidity mortality. In this study, we found that exosomes from human-bone-marrow-derived mesenchymal stem cells (hBMSC-Exos) play a protective role in hypoxia/reoxygenation (H/R) injury. hBMSC-Exos were enriched miR-199a-3p, hBMSC-Exo treatment increased expression level of miR-199a-3p renal cells. We further explored function on H/R was knocked down hBMSCs with inhibitor. HK-2...
Tumour‑associated macrophages (TAMs) compose a major component of the tumour microenvironment and form in this prior to cancer metastasis. However, detailed mechanisms TAM remodelling context bladder have not been clearly defined. The present study collected exosomes from conditioned medium human T24 cells. effects treated with derived cells on cell migration invasion were analysed by Transwell assays. expression levels endogenous exosomal microRNA‑21 (miR‑21) examined reverse...
Bone marrow–derived mesenchymal stem cells (BMSCs) have been recently reported to play a variety of vital roles in organ and tissue damage repair, mainly via potent paracrine activity, including secreting extracellular vesicles, such as exosomes, that serve mediators facilitating intercellular communication reprogramming recipient by delivering their contents target cells. However, the underlying mechanisms are diverse complex, influencing characteristics rarely studied. Accordingly, we...
Bladder cancer is a leading cause of morbidity and mortality worldwide.Currently, immunotherapy has become worthwhile therapy for bladder cancer.Tumor mutation burden (TMB) been regarded as the most prevalent biomarker to predict immunotherapy.Bladder reported have third highest rate.However, whether these gene mutations are related TMB immune response remain unknown.In this study, we downloaded somatic data from The Cancer Genome Atlas (TCGA) International Consortium (ICGC) datasets, found...
// Hubin Yin 1, 2 , Xiaoyu Yang Wen Gu 1 Yan Liu Xinyuan Li Xiaolong Huang Xin Zhu Yong Tao Gou and Weiyang He Department of Urology, The First Affiliated Hospital Chongqing Medical University, 400016, China Key Laboratory Molecular Oncology Epigenetics, Correspondence to: He, email: weiyang361@aliyun.com Gou, cymnk@163.com Keywords: high-mobility group box autophagy, chemoresistance, mitogen-activated protein kinase, bladder carcinoma Received: November 04,...
The aim of the study is described regulatory mechanisms and prognostic values differentially expressed RNAs in prostate cancer construct an mRNA signature that predicts survival. RNA profiles 499 tissues 52 non-prostate from TCGA were analyzed. differential expression was examined using edgeR package. Survival analyzed by Kaplan–Meier method. microRNA (miRNA), messenger (mRNA), long non-coding (lncRNA) networks miRcode database constructed, based on between tissues. A total 773 lncRNAs, 1417...
To explore the effects and underlying mechanisms of Mdivi-1 on three common clinical models acute kidney injury (AKI). Three AKI cell were constructed, classified into control group (human renal tubular epithelial cells [HK-2] cells), Iohexol (HK-2 treated with Iohexol), Genta Gentamicin), Cis Cisplatin). optimal protective concentration for each model, experimental design consisted following seven groups: cultured in medium), groups subjected to Iohexol, Gentamicin, or Cisplatin),...
Abstract Background Bladder cancer is one of the most prevalent malignancies worldwide. However, traditional indicators have limited predictive effects on clinical outcomes bladder cancer. The aim this study was to develop and validate a glycolysis-related gene signature for predicting prognosis patients with that therapeutic options. Methods mRNA expression profiling obtained from Cancer Genome Atlas (TCGA) database. Gene set enrichment analysis (GSEA) conducted identify glycolytic sets...
Background: Different proportions of Gleason pattern 3 and 4 lead to various prognosis prostate cancer with score 7. The objective this study was compare the survival outcomes 3+4 4+3 based on data from Surveillance, Epidemiology, End Results registry database, investigate independent prognosis-associated factors develop nomograms for predicting in 7 patients. Methods: A retrospective conducted 69,116 cases diagnosed as adenocarcinoma between 2004 2009. Prognosis-associated were evaluated...
This study investigates the docetaxel-resistant mechanism and explores effect of tea polyphenols (TP) on autophagy its related in human castration-resistant prostate cancer (CRPC) cell lines PC3 DU145.Immunofluorescence assay annexin V-FITC/PI double staining flow cytometry were used to analyze apoptosis DU145 cells. The expression autophagy-related proteins was detected by western bolt.Docetaxel could induce apoptosis, together with increase p-JNK, p-Bcl-2 Beclin1. level remarkably...
Tumor-infiltrating immune cells (TIICs) are crucial for the clinical outcome of renal cell carcinoma (RCC), as they regulate cancer progression. TIICs have therefore potential to become novel targets immunotherapies. The present study used CIBERSORT analytical tool, which is a deconvolution algorithm, comprehensively analyze composition in RCC and normal tissues from Cancer Genome Atlas (TCGA) cohort, determine prognostic value RCC. A landscape infiltrating was determined containing 13...
Abstract Bladder cancer is a highly heterogeneous and aggressive malignancy with poor prognosis. EGF/EGFR activation causes the detachment of SHC-binding protein 1 (SHCBP1) from SHC adapter (SHC1), which subsequently translocates into nucleus promotes development via multiple signaling pathways. However, role EGF-SHCBP1 axis in bladder progression remains unexplored. Herein, we report that SHCBP1 upregulated tissues cells, cytoplasmic or nuclear localization. Released responds to EGF...
Renal ischemia-reperfusion (I/R) injury is a leading cause of acute kidney (AKI), with high mortality. Recent studies have reported that human umbilical cord mesenchymal stem cells (HucMSCs) play an important role in repairing organ and tissue injuries because their unique characteristics. However, the potential HucMSC extracellular vesicles (HucMSC-EVs) to promote repair renal tubular remains be explored. This study found HucMSC-EVs derived from HucMSCs played protective were associated I/R...