A5111164900- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Photosynthetic Processes and Mechanisms
- RNA modifications and cancer
- Assisted Reproductive Technology and Twin Pregnancy
- Autophagy in Disease and Therapy
- Bladder and Urothelial Cancer Treatments
- Sarcoma Diagnosis and Treatment
- Reproductive Biology and Fertility
- Histone Deacetylase Inhibitors Research
- Immune cells in cancer
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Gut microbiota and health
- Lymphoma Diagnosis and Treatment
- Plant Molecular Biology Research
- Genomics and Phylogenetic Studies
- Laser-Plasma Interactions and Diagnostics
- Heterotopic Ossification and Related Conditions
- Chemotherapy-induced cardiotoxicity and mitigation
- Tannin, Tannase and Anticancer Activities
- Monoclonal and Polyclonal Antibodies Research
- Biochemical and Structural Characterization
- Immunotherapy and Immune Responses
China Medical University
2025
First Hospital of China Medical University
2025
Second Xiangya Hospital of Central South University
2025
Central South University
2025
Tongji Hospital
2022-2024
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
Huazhong University of Science and Technology
2021-2024
Daqing Oilfield General Hospital
2024
Zhejiang University
2024
Gallbladder cancer is the most common malignant tumor in biliary system. It has characteristics of low early diagnosis rate, strong invasiveness and high lymphatic metastasis rate. In recent years, with rapid development artificial intelligence technology, relevant technologies based on machine learning deep algorithms have been applied to treatment tumors, prognosis assessment medical image processing, bringing revolutionary changes mode tumors. At present, technology preliminarily studied...
Drought stress is one of the dominating challenges to growth and productivity in crop plants. Elucidating molecular mechanisms plants responses drought fundamental improve fruit quality. However, such are poorly understood apple (Malus domestica Borkh.). In this study, we explored that BTB-BACK-TAZ protein, MdBT2, negatively modulates tolerance plantlets. Moreover, identified a novel Homeodomain-leucine zipper (HD-Zip) transcription factor, MdHDZ27, using yeast two-hybrid (Y2H) screen with...
Metabolic rewiring underlies effective macrophages defense to respond disease microenvironment. However, the underlying mechanisms driving metabolic enhance macrophage effector functions remain unclear. Here, we demonstrated that reprogramming in inflammatory depended on acetylation of CLYBL, a citramalyl-CoA lyase, at lysine 154 (K154), and blocking CLYBL-K154 restricted release pro-inflammatory factors. Mechanistically, found crucial AMPK-CLYBL positive feedback loop, triggered by...
Bile acid metabolism mediated by gut microbiota is significantly related to immunity regulation that plays an important role in the development and treatment of inflammatory bowel disease (IBD). Our previous study has demonstrated Panax notoginseng saponins (PNS) alleviate colitis due T helper 17/Regulatory cells (Th17/Treg) balance via microbiota. However, effects mechanism PNS on pertinent bile remain elusive. This aims investigate anti-colitis regulating Th17/Treg microbiota–bile...
Research question Can machine learning models accurately predict the risk of early miscarriage following single vitrified-warmed blastocyst transfer (SVBT)? Design A dual-center retrospective analysis 1,664 SVBT cycles, including 308 cases, was conducted across two reproductive centers. Multiple models, such as Logistic Regression, Random Forest, Gradient Boosting, and Voting Classifier, were developed. Metrics Area Under Curve(AUC), accuracy, precision, recall, F1 score, specificity used to...
Abstract Anti-mitotic drugs are frequently used to treat cancer and many work by targeting microtubules disrupting the mitotic phase of cell cycle. However, dose-limiting toxicity associated with inhibition division in normal cells limits clinical benefit this drug class. The spindle assembly checkpoint (SAC) has emerged as a vulnerability for chromosomal instability due their increased dependence on proper chromosome alignment. KIF18A is kinesin family motor protein that promotes alignment...
In solid tumors, the formidable anti-tumor impact resulting from blocking "don't eat me" signal, arising CD47-SIRPα interaction, is constrained, especially compared to its efficacy in hematopoietic malignancies. Activating macrophage activity not only necessitates inhibition of but also activation "eat (pre-phagocyte) signal. Intriguingly, cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) antibody (Ab) has been identified stimulate Fc receptor-mediated active phagocytes tumor...
Objective: To investigate whether miR-125a-5p can inhibit the proliferation and invasion of breast cancer cells induce apoptosis by targeting GAB2. Methods: qRT-PCR was used to detect expression in normal mammary epithelial cell lines; The overexpression plasmid transiently transfected into MDA-MB-157 cells, proliferation, were detected CCK8 kit, Transwell chamber flow cytometry, respectively; Gene silencing knock down GAB2 gene changes invasion, apoptosis-related proteins chamber, cytometry...
Abstract Heterotopic bone occurs after burns, trauma and major orthopedic surgery, which cannot be completely cured by current treatments. The development of new treatments requires more in‐depth research into the mechanism HO. Available evidence suggests that miR‐21‐5p plays an important role in formation. However, its traumatic HO is still unclear. First, we identified exosomes extracted from L6 cells using TEM observation structure western blotting detection surface marker CD63....
Infertility affects one in six couples worldwide, with advanced maternal age (AMA) posing unique challenges due to diminished ovarian reserve and reduced oocyte quality. Single vitrified-warmed blastocyst transfer (SVBT) has shown promise assisted reproductive technology (ART), but success rates AMA patients remain suboptimal. This study aimed identify refine predictive factors for live birth following SVBT patients, the goal of enhancing clinical decision-making enabling personalized...
As a kind of anthracycline, doxorubicin (DOX) is commonly used as an antitumor drug, but its clinical application has been greatly hindered due to severe cardiotoxicity. Hence, in this study, we investigated the role catalpol (CTP) and effect on DOX-induced cardiotoxicity.The cardiac function mice was evaluated by assessing lactate dehydrogenase, creatine kinase isoenzyme, heart weight body weight, weight/tibia length levels. Histopathological changes were observed using hematoxylin eosin...
PurposeTo study the role of mitochondrial metabolism and obtain novel biomarkers in immunotherapy for non-small cell lung cancer (NSCLC).MethodsWe collected 188 genes involved metabolism(MMGs) from MSIGDB project then quantified activity metabolism. All NSCLC patients were divided into C1 C2 clusters based on 26 prognosis-related MMGs. The differences biology, differential immune microenvironment, chronic hypoxia prognosis between also analyzed. In addition, we validated results...
Abstract Previous studies have shown that psoralen can treat osteoporosis by inducing osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). CKIP-1 is an inhibitor formation and plays a negative regulatory role in the BMSCs. MicroRNA (miRNA) kind small single-stranded non-coding RNA, which regulates occurrence development process cell proliferation, apoptosis, metabolism. Studies miRNA affect proliferation BMSCs targeting regulating expression related genes. However,...
Abstract Backgroud Accumulating evidence supports the concept that DNA damage response (DDR) targeted therapies can improve antitumor immune by increasing immunogenicity of tumor cells and improving microenvironment. Ataxia telangiectasia mutated (ATM) is a core component repair system. Although ATM gene has significant mutation rate in many human cancers including colorectal, prostate, lung, breast, it remains understudied compared with other DDR-involved molecules such as PARP ATR. There...
Necroptosis is a type of programmed cell death involved in the pathogenesis cancers. This work developed prognostic glioblastoma (GBM) model based on necroptosis-related genes.
Purpose This study aimed to develop a predictive model for assessing clinical pregnancy probabilities in patients undergoing frozen-thawed cycles with single Day 6 blastocyst transfers. Methods We conducted two-center retrospective cohort analyzing 1,381 transfer from June 2016 December 2022. The primary outcome was the rate per cycle. Data were divided into training, testing, and validation groups 6:2:2 ratio. Univariate LASSO regression analyses identified factors influencing pregnancy,...
Clear cell renal carcinoma (ccRCC) represents a frequent subtype of kidney cancer, with the prognosis remaining poor for individuals metastatic disease. Given its resistance to both radiation and chemotherapy, targeted therapies immunotherapies have emerged as critical effective ccRCC treatment. Within this context, SNARE protein STX4, which is associated malignant cancer migration, provides promising focus. The underlying mechanism, however, requires further illumination. Furthermore,...