A5043169198- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Endometrial and Cervical Cancer Treatments
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- RNA Research and Splicing
- Pregnancy and Medication Impact
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- MicroRNA in disease regulation
- Prenatal Screening and Diagnostics
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Synthesis of Organic Compounds
- Reproductive Physiology in Livestock
- Asymmetric Hydrogenation and Catalysis
- Carbohydrate Chemistry and Synthesis
- Oxidative Organic Chemistry Reactions
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- Cancer-related gene regulation
First Affiliated Hospital of GuangXi Medical University
2018-2025
Guangxi Medical University
2018-2025
Hebei University of Science and Technology
2009-2024
Zhongnan Hospital of Wuhan University
2024
Nanjing Drum Tower Hospital
2024
Beijing University of Chinese Medicine
2024
Wuhan University
2024
Victor Chang Cardiac Research Institute
2024
Tumor Hospital of Guangxi Medical University
2022-2023
Sun Yat-sen University
2016-2022
Abstract Background Pancreatic cancer is one of the most lethal types with extremely poor diagnosis and prognosis, chemo-resistance remains a major challenge. The dynamic reversible N 6 -methyladenosine (m A) RNA modification has emerged as new layer epigenetic gene regulation. Methods qRT-PCR IHC were applied to examine ALKBH5 levels in normal pancreatic tissues. Cancer cell proliferation evaluated by clonogenic formation, chemosensitivity detection, Western blotting assays. m A-seq was...
Abstract The Protocadherin 10 (PCDH10) is inactivated often by promoter hypermethylation in various human tumors, but its possible functional role as a tumor suppressor gene not established. In this study, we identify PCDH10 novel Wnt pathway regulatory element endometrioid endometrial carcinoma (EEC). was downregulated EEC cells aberrant methylation of promoter. Restoring levels suppressed cell growth and triggered apoptosis xenografts. Gene expression profiling revealed part the...
The endometrium becomes receptive to the embryo only in mid-luteal phase, but not other stages of menstrual cycle. Endometrial factors play an important role implantation. Women with recurrent miscarriage and implantation failure have both been reported altered expression receptivity markers during window We aimed compare gene profiles among women unexplained failures (RIF) miscarriages (RM) by RNA sequencing (RNA-Seq). In total 20 patients (9 RIF 11 RM) were recruited. addition 4 fertile...
In the endometrium of women with recurrent implantation failure and unexplained miscarriage, expression levels homeobox A10 E-cadherin were positively correlated. To explore whether regulates during endometrial receptivity establishment, Ishikawa RL95-2 cells transfected target-specific small interfering RNA (siRNA) overexpression plasmid A10. The measured by western blot quantitative Real-time Polymerase Chain Reaction (qRT-PCR). Attachment assay JEG-3 spheroids to conducted adhesive...
Amide bond constructions are crucial in peptide synthesis and pharmaceutical chemistry research.The traditional methods of require the use excessive amounts reagents solvents, posing a threat to environment human health.It is still current research focus develop environmentally friendly novel acylation efficient, green, sustainable amide methods.From green chemistry's principles, this paper focused on efficient formation bonds peptide, including catalysis elemental organic chemicals, some...
Abstract The direct amidation of amino acid derivatives catalyzed by arylboronic acids has been examined. reaction was generally slow relative to simple amine‐carboxylic combinations though proceeded at 65–68 °C avoiding racemization. 3,4,5‐Trifluorophenylboronic and o ‐nitrophenylboronic were found be the best catalysts, for slower dipeptide formations, high catalyst loadings required an interesting synergistic catalytic effect between two discovered.
Enhancer of zeste homolog 2 (EZH2) catalyses histone H3 lysine 27 trimethylation (H3K27me3) to silence tumour-suppressor genes in hepatocellular carcinoma (HCC) but the process locus-specific recruitment remains elusive. Here we investigated transcription factors involved and molecular consequences HCC development. The genome-wide distribution H3K27me3 was determined by chromatin immunoprecipitation coupled with high-throughput sequencing or promoter array analyses cells from hepatitis B...
This study investigates the impact of progesterone resistance on endometrial receptivity and evaluates efficacy pituitary downregulation combined with hormone replacement therapy (HRT) in improving pregnancy outcomes following frozen embryo transfer (FET). A retrospective analysis was conducted 147 patients recurrent implantation failure (RIF) who underwent secretory-phase biopsy subsequent FET treatments at Reproductive Center First Affiliated Hospital Guangxi Medical University between...
The establishment of pregnancy in human necessitates appropriate decidualization stromal cells, which involves steroids regulated periodic transformation endometrial cells during the menstrual cycle. However, potential molecular regulatory mechanism underlying initiation and maintenance humans is yet to be fully elucidated. In this investigation, we document that SOX4 a key regulator by directly regulating FOXO1 expression as revealed whole genomic binding assay RNA sequencing. Besides, our...
Amorphous nickel powder (Ni(0)) was utilised as a catalyst under mild, aqueous, basic conditions for enhancing the sodium borohydride-mediated reduction of C-N multiple bonds such oximes, imines, hydrazones and nitriles to produce corresponding amines in good excellent yields.
A formal synthesis of cephalotaxine, the parent member Cephalotaxus alkaloids, was achieved. It features a practical four-step assembly benzazepine-bearing pentacyclic ring system through two alkylation reactions, acidic hydrolysis, and aldolization.
Abstract Angiogenesis is a physiological process for endometrial regeneration in the menstrual cycle and remodeling during pregnancy. Endogenous hydrogen sulfide (H2S), produced by cystathionine-β synthase (CBS) cystathionine-γ lyase (CSE), potent proangiogenic factor; yet, whether H2S system expressed endometrium plays role angiogenesis are unknown. This study was to test estrogens stimulate biosynthesis promote microvascular endothelial cell (EMEC) angiogenesis. CBS messenger RNA/protein...
Recurrent miscarriage (RM) is a chronic, heterogeneous autoimmune disease that has serious social and personal consequences. No valid reliable diagnostic markers or therapeutic targets for RM have been identified. Macrophages impact the innate immune system can be used as prognostic many diseases. We first collected 16 decidua villi tissue samples from 5 normal patients 3 single-cell RNA sequencing data analysis identified 1293 macrophage marker genes. then screened recurrent cohort...