A5032174631- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- RNA Research and Splicing
- Endometriosis Research and Treatment
- Cancer Genomics and Diagnostics
- Uterine Myomas and Treatments
- Pregnancy and Medication Impact
- Sarcoma Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Circular RNAs in diseases
- Reproductive System and Pregnancy
- Cancer, Lipids, and Metabolism
- Electrolyte and hormonal disorders
- Cancer Cells and Metastasis
- Beetle Biology and Toxicology Studies
- Radiomics and Machine Learning in Medical Imaging
- Cytokine Signaling Pathways and Interactions
- MRI in cancer diagnosis
- Cardiovascular Disease and Adiposity
- MicroRNA in disease regulation
- Pharmacological Effects and Toxicity Studies
- 14-3-3 protein interactions
- Ureteral procedures and complications
Haukeland University Hospital
2015-2024
University of Bergen
2015-2024
Beijing Obstetrics and Gynecology Hospital
2019
Emory University
2014
Uni Research (Norway)
2013
University Medical Center Hamburg-Eppendorf
2013
Universität Hamburg
2013
Eastern Nazarene College
2013
QIMR Berghofer Medical Research Institute
2012
Centre for Human Genetics
2012
Oncogenic activation of tyrosine kinases is a common mechanism carcinogenesis and, given the druggable nature these enzymes, an attractive target for anticancer therapy. Here, we show that somatic mutations fibroblast growth factor receptor 2 (FGFR2) kinase gene, FGFR2 , are present in 12% endometrial carcinomas, with additional instances found lung squamous cell carcinoma and cervical carcinoma. These mutations, many which identical to associated congenital craniofacial developmental...
Although 75% of endometrial cancers are treated at an early stage, 15% to 20% these recur. We performed integrated analysis genome-wide expression and copy-number data for primary carcinomas with extensive clinical histopathological detect features predictive recurrent disease. Unsupervised the distinguished 2 major clusters strikingly different phenotypes, including significant differences in disease-free survival. To identify possible mechanisms differences, we a global genomic survey...
Preoperative histologic examination of tumour tissue is essential when deciding if endometrial cancer surgery should include lymph node sampling. We wanted to investigate biomarkers could improve prediction metastasis and outcome.Curettage specimens from 832 carcinoma patients prospectively recruited 10 centres in the MoMaTEC trial (Molecular Markers Treatment Endometrial Cancer) were investigated for hormone receptor p53 status.Eighteen per cent tumours double negative oestrogen-...
// Geir Bredholt 1, * , Monica Mannelqvist Ingunn M. Stefansson 2 Even Birkeland 1 Trond Hellem Bø 3 Anne Øyan 4, 5 Jone Trovik 5, 6 Karl-Henning Kalland Inge Jonassen Helga B. Salvesen Elisabeth Wik Lars A. Akslen Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, Section Pathology, University Bergen, Norway Haukeland Hospital, Informatics, 4 Microbiology, Center Science, Gynecology and Obstetrics, These authors have contributed equally to this work Correspondence to:...
We hypothesized that estrogen receptor-α (ER-α) status in endometrial carcinomas, associated with poor prognosis, is reflected transcriptional signatures suggesting targets for new therapy.Endometrial carcinoma samples a primary investigation cohort (n = 76) and three independent validation cohorts 155/286/111) were analyzed through integrated molecular profiling. Biomarkers assessed by immunohistochemistry (IHC), DNA oligonucleotide microarray, quantitative PCR (qPCR), single-nucleotide...
Abstract The Protocadherin 10 (PCDH10) is inactivated often by promoter hypermethylation in various human tumors, but its possible functional role as a tumor suppressor gene not established. In this study, we identify PCDH10 novel Wnt pathway regulatory element endometrioid endometrial carcinoma (EEC). was downregulated EEC cells aberrant methylation of promoter. Restoring levels suppressed cell growth and triggered apoptosis xenografts. Gene expression profiling revealed part the...
Overexpression of the oncogen Stathmin has been linked to aggressive endometrial carcinoma and a potential for PI3Kinase inhibitors in this disease. We wanted validate prognostic value expression large prospective multicenter setting. As lymph node sampling is part current surgical staging, we also aimed test if curettage specimens could predict metastasis.A total 1,076 cancer patients have recruited from 10 centers investigate biological tumor marker relation clinicopathologic variables,...
Background Improved methods for preoperative risk stratification in endometrial cancer are highly requested by gynecologists. Texture analysis is a method quantification of heterogeneity images, increasingly reported as promising diagnostic tool various types, but largely unexplored cancer. Purpose To explore whether tumor texture parameters from MRI related to known prognostic features (deep myometrial invasion, cervical stroma lymph node metastases, and high‐risk histological subtype)...
The English questionnaire Pregnancy-Unique Quantification of Emesis and nausea (PUQE) identifies women with severe Hyperemesis Gravidarum. Our aim was to investigate whether scores from the translated Norwegian version; SUKK (SvangerskapsUtløst Kvalme Kvantifisering) associated severity hyperemesis nutritional intake.A prospective cohort validation study.Hospital Gravidarum (HG) patients western Norway healthy pregnant Bergen, Norway.38 hospitalized due HG 31 controls attending routine...
About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk unfavorable prognosis. In the framework European Network for Individualized Treatment in EC (ENITEC), we investigated presence and phenotypic features Circulating Tumor Cells (CTC) patients. CTC isolation was carried out peripheral blood samples from 34 patients, ranging Grade 3 Stage IB to IV carcinomas recurrences, 27 healthy controls using two methodologies. Samples were subjected EpCAM-based...
Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression a strong prognostic marker in stage I EECs, but less known about L1CAM advanced-stage EECs NEECs. This study analyses clinically representative cohort carcinomas.The was immunohistochemically determined 1199 carcinomas, treated at one the European Network for Individualized Treatment Endometrial Cancer (ENITEC)...
Our objective was to prospectively explore the diagnostic value of <sup>18</sup>F-FDG PET/CT for preoperative staging in endometrial carcinomas and investigate whether PET–specific quantitative tumor parameters reflect clinical histologic characteristics. <b>Methods:</b> Preoperative performed on 129 consecutive carcinoma patients. Two physicians who did not know findings or results independently reviewed images, assessing primary tumor, cervical stroma involvement metastatic spread,...
Chromatin organisation affects gene expression and regional mutation frequencies contributes to carcinogenesis. Aberrant of DNA has been correlated with cancer prognosis in analyses the chromatin component tumour cell nuclei using image texture analysis. As yet, methodology not sufficiently validated permit its clinical application. We aimed define validate a novel prognostic biomarker for automatic detection heterogeneous organisation.
Chromosome 8q24 is the most commonly amplified region across multiple cancer types, and typical length of amplification suggests that it may target additional genes to MYC. To explore roles frequently included in amplifications, we analyzed relation between copy number alterations gene expression three sets endometrial cancers (N = 252); glioblastoma, ovarian, breast profiled by TCGA. Among neighbouring MYC, bromodomain-containing ATAD2 was associated with amplification....
Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancer and estradiol (E 2 ) concentrations. We analyzed 2937 single nucleotide polymorphisms (SNPs) in 6608 cases 37 925 controls report the first genome wide-significant association between a SNP (rs727479 intron 2, P =4.8×10 −11 ). rs727479 was also among those most strongly circulating E concentrations 2767 post-menopausal ( =7.4×10 −8 The observed odds ratio per A-allele (1.15, CI=1.11–1.21) is...