A5023637812- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Gynecological conditions and treatments
- Ovarian function and disorders
- Estrogen and related hormone effects
- Pregnancy-related medical research
- Maternal and Perinatal Health Interventions
- Reproductive Health and Contraception
- Ectopic Pregnancy Diagnosis and Management
- Pelvic floor disorders treatments
- Telomeres, Telomerase, and Senescence
- Maternal and fetal healthcare
- Maternal Mental Health During Pregnancy and Postpartum
- Menopause: Health Impacts and Treatments
- Gestational Diabetes Research and Management
- Diversity and Career in Medicine
- Reproductive Health and Technologies
- Sexual function and dysfunction studies
- Pregnancy and preeclampsia studies
- Grief, Bereavement, and Mental Health
- Reproductive Biology and Fertility
- Prenatal Screening and Diagnostics
Liverpool Women's Hospital
2016-2025
University of Liverpool
2016-2025
Liverpool Womens NHS Foundation Trust
2016-2025
National Health Service
2025
HealthPartners
2024
University of Oxford
2021
Université de Lorraine
2020
Centre Hospitalier Régional de Metz-Thionville
2020
Eastern Nazarene College
2013
Singapore-MIT Alliance for Research and Technology
2013
About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk unfavorable prognosis. In the framework European Network for Individualized Treatment in EC (ENITEC), we investigated presence and phenotypic features Circulating Tumor Cells (CTC) patients. CTC isolation was carried out peripheral blood samples from 34 patients, ranging Grade 3 Stage IB to IV carcinomas recurrences, 27 healthy controls using two methodologies. Samples were subjected EpCAM-based...
In women, a single dose of the antiprogestin mifepristone (RU486) in secretory phase rapidly renders endometrium unreceptive and is followed by endometrial breakdown menstruation within 72 h. This model provides system to identify progesterone-regulated genes, which may be involved receptivity induction menstruation. We used cDNA microarrays monitor response endometriuim over 24 h following administration mid-secretory phase. identified 571 transcripts whose expression was significantly...
Asoprisnil, a novel orally active selective progesterone receptor modulator, is being studied for the management of symptomatic uterine leiomyomata. The exact mechanism action not yet discerned. primary objectives this double-blind, randomized, placebo-controlled study included evaluation effect asoprisnil on artery blood flow. Furthermore, we assessed effects leiomyoma symptoms.Thirty-three premenopausal patients scheduled hysterectomy due to leiomyomata were recruited in four centers and...
In order to test our hypothesis that endometriosis is associated with abnormal expression of telomerase and telomere lengthening in endometrium, we assessed endometrial the human enzyme length (TL).This prospective pilot study, included 29 women symptomatic, surgically diagnosed (Group 1) 27 healthy, fertile, symptom-free without 2, confirmed by laparoscopy). Seventeen Group 1 15 2 had biopsies taken on Day 21 +/- cycle. A further 12 each group were biopsied 26 2. Telomerase estrogen...
How does steroid receptor expression, proliferative activity and hormone responsiveness of the fallopian tube (FT) epithelium compare to that endometrial epithelium?Proliferative indices, expression-scores in vitro response oestrogen androgens human FT demonstrate a distinct pattern from matched endometrium.The exists as continuum endometrium, both express receptors. The ovarian hormones regulate cyclical proliferation regeneration but their effects on expression have not yet been fully...
Is endometriosis associated with abnormally located endometrial basalis-like (SSEA1+/SOX9+) cells in the secretory phase functionalis and could they contribute to ectopic endometriotic lesion formation?Women had an higher number of SSEA1+/SOX9+ epithelial present stratum and, since these formed 3D structures vitro phenotypic similarities lesions, may generate lesions following retrograde menstruation.Endometrial basalis progenitor potential are postulated play a role pathogenesis SSEA1...
BackgroundChronic pelvic pain affects 2–24% of women worldwide and evidence for medical treatments is scarce. Gabapentin effective in treating some chronic conditions. We aimed to measure the efficacy safety gabapentin with no obvious pathology.MethodsWe performed a multicentre, randomised, double-blind, placebo-controlled randomised trial 39 UK hospital centres. Eligible participants were (with or without dysmenorrhoea dyspareunia) at least 3 months duration. Inclusion criteria 18–50 years...
Regular menstrual shedding and repair of the endometrial functionalis is unique to humans higher-order primates. The current consensus postulates glands have a single-tubular architecture, where multi-potential stem cells reside in blind-ending glandular-bases. Utilising fixed samples from patients, we studied three-dimensional (3D) micro-architecture human endometrium. We demonstrate that some non-branching, single, vertical originate complex horizontally interconnecting network basalis...
Endometriosis is a common condition associated with growth of endometrial-like tissue beyond the uterine cavity. Previous reports have suggested role for uNK cells in pathogenesis endometriosis postulating that survival and accumulation menstrual endometrial peritoneal cavity may relate to reduction cytotoxic activity peripheral blood NK cells. We aimed assess differences percentage their phenotypical characterization eutopic ectopic samples from women without baboons induced endometriosis....