A5032434810- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Ectopic Pregnancy Diagnosis and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Endometriosis Research and Treatment
- Cancer Research and Treatments
- Uterine Myomas and Treatments
- Maternal and fetal healthcare
- Cervical Cancer and HPV Research
- Intraperitoneal and Appendiceal Malignancies
- Acute Myeloid Leukemia Research
- Gynecological conditions and treatments
- Wildlife Ecology and Conservation
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Blood groups and transfusion
- Species Distribution and Climate Change
- Vector-borne infectious diseases
- Global Cancer Incidence and Screening
- Conservation, Biodiversity, and Resource Management
- Eosinophilic Disorders and Syndromes
- Chronic Myeloid Leukemia Treatments
- Gestational Trophoblastic Disease Studies
Royal London Hospital
2017-2024
Barts Health NHS Trust
2016-2024
Guy's and St Thomas' NHS Foundation Trust
2023-2024
St Thomas' Hospital
2023-2024
West Virginia University
2024
Guy's Hospital
2023-2024
University of Bayreuth
2018-2023
Government of the United Kingdom
2023
Australia New Zealand Gynaecological Oncology Group
2023
Homerton University Hospital
2021
To describe first-trimester ultrasound diagnosis and management of pregnancies implanted into uterine Cesarean section scars.All women referred for an scan because suspected early pregnancy complications were screened a previous scar. The scar included transvaginal surgical evacuation, medical treatment with local injection 25 mg methotrexate the exocelomic cavity expectant management.Eighteen diagnosed in 4-year period. prevalence population was 1 : 1800 pregnancies. Surgical used eight it...
The purpose of this study was to assess the effect neoadjuvant chemotherapy (NACT) on immune activation in stage IIIC/IV tubo-ovarian high-grade serous carcinoma (HGSC), and its relationship treatment response. We obtained pre- posttreatment omental biopsies blood samples from a total 54 patients undergoing platinum-based NACT 6 primary debulking surgery. measured T-cell density phenotype, activation, markers cancer-related inflammation using IHC, flow cytometry, electrochemiluminescence...
Asoprisnil, a novel orally active selective progesterone receptor modulator, is being studied for the management of symptomatic uterine leiomyomata. The exact mechanism action not yet discerned. primary objectives this double-blind, randomized, placebo-controlled study included evaluation effect asoprisnil on artery blood flow. Furthermore, we assessed effects leiomyoma symptoms.Thirty-three premenopausal patients scheduled hysterectomy due to leiomyomata were recruited in four centers and...
Background Nintedanib slows progression of lung function decline in patients with progressive fibrosing (PF) interstitial disease (ILD) and was recommended for this indication within the United Kingdom (UK) National Health Service Scotland June 2021 England, Wales Northern Ireland November 2021. To date, there has been no national evaluation use nintedanib PF-ILD a real-world setting. Methods 26 UK centres were invited to take part service between 17 30 September 2022. Summary data regarding...
Habitat loss and forest fragmentation are often linked to increased pathogen transmission, but the extent which habitat isolation landscape connectivity affect disease dynamics through movement of vectors reservoir hosts has not been well examined. Tick-borne diseases most prevalent vector-borne in United States on West Coast, Ixodes pacificus is one epidemiologically important vectors. We investigated impacts pathogens transmitted by I. sought disentangle effects wildlife communities...
To assess prospectively the ability of two multiparameter diagnostic models and their individual components to predict outcome early pregnancies which could not be identified on transvaginal ultrasound scan.Prospective observational study.Dedicated pregnancy unit in an inner city teaching hospital.Women with a positive urine test clinical suspicion complications.A full medical history, examination scan were carried out at initial visit. When location ascertained by ultrasound, serum...
We present findings of a cancer multidisciplinary-team (MDT) coordinated mainstreaming pathway unselected 5-panel germline BRCA1/BRCA2/RAD51C/RAD51D/BRIP1 and parallel somatic BRCA1/BRCA2 testing in all women with epithelial-OC highlight the discordance between strategies across two centres. Patients were counselled consented by MDT member. The uptake multi-gene was 97.7%. Counselling clinical-nurse-specialist more frequently needed >1 consultation (53.6% (30/56)) compared to medical...
Habitat loss from anthropogenic development has led to an unprecedented decline in global biodiversity. Protected areas (PAs) exist counteract this degradation of ecosystems. In the European Union, Natura 2000 (N2k) network is basis for continent-wide conservation efforts. N2k world's largest coordinated protected areas. However, threats ecosystems do not stop at borders PAs. As measured by a landscape fragmentation metric, can affect interiors To ensure long-term viability PAs, paper...
Abstract Habitat destruction and loss are the gravest threats to wildlife worldwide. We examined correlation between habitat patch size species richness abundance of mammals reptiles in a biodiversity hotspot California. Within nine forest fragments standardized for age, topography, climate, vegetation cover, we tested effects isolation on biodiversity. To measure abundance, used cameras meso‐and‐large vertebrates, mark‐and‐recapture analyses small mammals, mark‐and‐resight analysis...
Abstract The Natura 2000 (N2K) protected area (PA) network is a crucial tool to limit biodiversity loss in Europe. Despite covering 18% of the European Union's (EU) land area, its effectiveness at conserving across taxa and biogeographic regions remains uncertain. Testing this is, however, difficult because it requires considering nonrandom location PAs, many possible confounding factors. We used propensity score matching accounted for effects regions, terrain ruggedness, cover assess N2K...
The impact of autoantibody profiles on prognosis idiopathic inflammatory myositis associated interstitial lung disease (IIM-ILD) and spectrum ILD with Myositis Specific Antibodies (MSA) remains unclear. This retrospective cohort study examines whether serological are mortality longitudinal function change.Baseline clinical/demographic characteristics follow-up consecutive adult patients IIM-ILD or Interstitial Pneumonia Autoimmune Features (IPAF) positive for MSAs were extracted from three...
Obstetrical & Gynecological Survey: September 2003 - Volume 58 Issue 9 p 567-569 doi: 10.1097/01.OGX.0000083703.38427.00
A 33-year-old woman with a history of light vaginal bleeding was referred for an ultrasound scan at 4 weeks' gestation. In her previous pregnancy she had emergency Cesarean section term due to failure progress. Her medical and surgical histories were unremarkable. The uterine cavity appeared empty on transvaginal scan. small gestational sac measuring 11 mm in diameter identified the level internal os (Figure 1). implanted anteriorly overlying scar, which as thin hyperechoic band...
Habitat loss from unrelenting human pressure is causing an unprecedented decline in global biodiversity. Protected areas (PAs) are meant to counteract and fragmentation of ecosystems today PAs form the backbone conservation strategies worldwide. However, anthropogenic climate change can severely reduce effectiveness PAs. Conservation professionals need concrete spatial information on climatic changes within order put forward practicable safeguard PA face change. In this study, we take...
Three patients with M2 acute myeloid leukemia (AML) in whom cord compression developed due to epidural granulocytic sarcoma are reported and compared six similar described previously. These three cases had 8;21 translocation, t (8;21), the marrow karyotype also of tissue obtained from two cases. Treatment chemotherapy radiotherapy can be effective, but an emergency laminectomy should performed if there is rapid neurologic progression.
The iron content of human nails has been measured by atomic absorption spectrophotometry and compared with other measurements status including the bone marrow. Four groups individuals were studied: 40 healthy laboratory staff, five iron-deficient subjects before during therapy, four patients at various stages treatment iron, 15 postmortem cases. individual was reflected amount present in nail samples. Nail sampling is proposed as a cheap, noninvasive method assessing individual.
SUMMARY A controlled trial involving unselected patients was performed in which 20 g. or mg. of E.A.C.A. were administered intravenously over a period twenty–four hours immediately following retropubic prostatectomy for benign hyperplasia.
Background Human papillomavirus (HPV) testing of self-collected vaginal samples has potential to improve coverage cervical screening programmes, but current guidelines mostly require those HPV positive on a self-sample attend for routine screening. Methods and findings A pragmatic modified stepped-wedge implementation feasibility trial was conducted at primary care practices in England. Individuals aged 25 64 years who were least 6 months overdue could provide sample. The outcomes included...