A5103020322- Ovarian cancer diagnosis and treatment
- BRCA gene mutations in cancer
- Endometrial and Cervical Cancer Treatments
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- dental development and anomalies
- Endometriosis Research and Treatment
- Cancer Genomics and Diagnostics
- Surgical Simulation and Training
- Cervical Cancer and HPV Research
- T-cell and B-cell Immunology
- Intraperitoneal and Appendiceal Malignancies
- Hematopoietic Stem Cell Transplantation
- Cardiac, Anesthesia and Surgical Outcomes
- Bone and Dental Protein Studies
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Dental Trauma and Treatments
- Viral gastroenteritis research and epidemiology
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Nutrition, Genetics, and Disease
- Estrogen and related hormone effects
- Virus-based gene therapy research
- Ureteral procedures and complications
University College Hospital
2022-2025
University College London
2022-2025
University College London Hospitals NHS Foundation Trust
2022-2025
Queen Mary University of London
2007-2024
Royal London Hospital
2019-2024
London Women's Clinic
2024
Royal Marsden NHS Foundation Trust
2023
St Bartholomew's Hospital
2018-2022
Tamil Nadu Veterinary and Animal Sciences University
2021
Barts Health NHS Trust
2019-2021
Abstract The restoration of dentine lost in deep caries lesions teeth is a routine and common treatment that involves the use inorganic cements based on calcium or silicon-based mineral aggregates. Such remain tooth fail to degrade thus normal volume never completely restored. Here we describe novel, biological approach stimulates natural formation reparative via mobilisation resident stem cells pulp. Biodegradable, clinically-approved collagen sponges are used deliver low doses small...
In non-growing teeth, such as mouse and human molars, primary odontoblasts are long-lived post-mitotic cells that secrete dentine throughout the life of tooth. New odontoblast-like only produced in response to a damage or trauma. Little is known about molecular events initiate mesenchymal stem proliferate differentiate into damage. The reparative regenerative capacity multiple mammalian tissues depends on activation Wnt/β-catenin signaling pathway. this study, we investigated role pathway...
The canonical Wnt/β-catenin signaling pathway is crucial for reparative dentinogenesis following tooth damage, and the modulation of this affects rate extent dentine formation in damaged mice molars by triggering natural process dentinogenesis. Pharmacological stimulation activity small-molecule GSK-3 inhibitor drugs pulp exposure mouse results creation similar but larger lesions rat shows that adenosine triphosphate (ATP)–competitive inhibitor, CHIR99021 (CHIR), ATP noncompetitive...
Background Human papillomaviruses (HPVs) are sexually transmitted human carcinogens that may play a role in the oncogenesis of penile cancer. Objectives To investigate HPV infection and expression tumour suppressor protein p16INK4A pathogenesis Methods By means polymerase chain reaction amplification reverse hybridization line probe assay to detect infection, immunohistochemical staining for Ki67, we analysed 26 squamous cell carcinomas (SCCs) 20 independent lichen sclerosus (LS) lesions...
Abstract Immunosuppression (IS) withdrawal from calcineurin inhibitors is only possible in ˜20% of liver transplant recipients. However, mammalian target rapamycin (e.g., sirolimus; SRL) appear to be more immunoregulatory and might promote a tolerant state for withdrawal. Our aim was determine whether systemic (i.e., blood, marrow, allograft) signatures immunoregulation are promoted by conversion tacrolimus (TAC) SRL. We therefore performed the following serial assays before after SRL...
We present findings of a cancer multidisciplinary-team (MDT) coordinated mainstreaming pathway unselected 5-panel germline BRCA1/BRCA2/RAD51C/RAD51D/BRIP1 and parallel somatic BRCA1/BRCA2 testing in all women with epithelial-OC highlight the discordance between strategies across two centres. Patients were counselled consented by MDT member. The uptake multi-gene was 97.7%. Counselling clinical-nurse-specialist more frequently needed >1 consultation (53.6% (30/56)) compared to medical...
For healthcare institutions developing a robotic programme, delivering value for patients, clinicians, and payers is key. However, the impact on surgeon, training pathways, logistics are often overlooked. We conducted study of surgery surgeons, access to surgical training, factors associated with successful programme. In our international mixed-methods study, customised web-based survey was circulated gynaecological oncologists. The Wilcoxon rank-sum test Fisher's exact test, tested...
It is unclear if new costimulatory blockade agents, such as the cytotoxic T lymphocyte-associated antigen 4-Ig molecule belatacept (BEL), promote or inhibit potential for immunologic tolerance in transplantation. We therefore tested vitro effects of BEL on human regulatory cells (Tregs) mixed lymphocyte reactions (MLR) alone and combination with maintenance agents used transplant recipients.
Abstract Endometrial cancer (EC) is the most prevalent gynaecological in high‐income countries and its incidence continuing to rise sharply. Simple objective tools reliably detect women with EC are urgently needed. We recently developed validated DNA methylation (DNAme)‐based women's risk identification—quantitative polymerase chain reaction test for endometrial (WID‐qEC) that could address this need. Here, we demonstrate stability of WID‐qEC remains consistent regardless of: (i)...
Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC stratification general population women using tool followed by management. Volunteers were recruited through London primary care networks. Inclusion criteria: ≥18 years. Exclusion prior ovarian/tubal/peritoneal cancer, previous genetic testing for genes. Participants accessed an...
Ultrasonography is a core skill required by all obstetrics and gynecology trainees; however, training opportunities in clinical ultrasound are declining. Simulation has been proposed as strategy to overcome this.The study aims were determine the current availability of simulation United Kingdom explore trainees' perspective on role simulation.All trainees within East Midlands Local Education Training Board asked complete an anonymous web-based survey July 2014.Of 140 trainees, 70 (50%)...
Objective To determine risk‐reducing early salpingectomy and delayed oophorectomy (RRESDO) acceptability effect of surgical prevention on menopausal sequelae/satisfaction/regret in women at increased ovarian cancer (OC) risk. Design Multicentre, cohort, questionnaire study (IRSCTN:12310993). Setting United Kingdom (UK). Population UK without OC ≥18 years, risk, with/without previous RRSO, ascertained through specialist familial cancer/genetic clinics BRCA support groups. Methods Participants...
Background Acceptance of the role fallopian tube in ‘ovarian’ carcinogenesis and detrimental sequelae surgical menopause premenopausal women following risk-reducing salpingo-oophorectomy (RRSO) has resulted early-salpingectomy with delayed oophorectomy (RRESDO) being proposed as an attractive alternative strategy who decline/delay oophorectomy. We present results a qualitative study evaluating decision-making process among BRCA carriers considering prophylactic surgeries (RRSO/RRESDO) part...
Parallel panel germline and somatic genetic testing of all patients with ovarian cancer (OC) can identify more pathogenic variants (PVs) that would benefit from PARP inhibitor (PARPi) therapy, allow for precision prevention in unaffected relatives PVs. In this study, we estimate the cost-effectiveness population impact parallel BRCA OC incorporating PARPi therapy United Kingdom States compared clinical criteria/family history (FH)-based testing. We also evaluate multigene alone.
The peritoneal cancer index quantitatively assesses distribution and tumor burden in the cavity. aim of this study is to evaluate association between completeness surgical cytoreduction for ovarian identify a cut-off above which complete unlikely.This single-center prospective cohort observational study. A total 100 consecutive patients who underwent surgery were included. Peritoneal scores prior after calculated, value incomplete was identified using receiver operator characteristic (ROC)...
Unselected population-based personalised ovarian cancer (OC) risk assessments combining genetic, epidemiological and hormonal data have not previously been undertaken. We aimed to understand the attitudes, experiences impact on emotional well-being of women from general population who underwent unselected genetic testing (PGT) for OC prediction received low-risk (<5% lifetime risk) results. This qualitative study was set within recruitment a pilot PGT using an tool telephone helpline....