Aleksandra Gentry‐Maharaj
A5050794198- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Endometriosis Research and Treatment
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- RNA Research and Splicing
- Virus-based gene therapy research
- Cancer Risks and Factors
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- CRISPR and Genetic Engineering
- Bioinformatics and Genomic Networks
- Colorectal Cancer Screening and Detection
- Nutrition, Genetics, and Disease
- Molecular Biology Techniques and Applications
- Genetic factors in colorectal cancer
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
University College London
2016-2025
London Women's Clinic
2010-2024
MRC Clinical Trials Unit at UCL
2018-2024
Medical Research Council
2009-2024
Institute for Women's Policy Research
2023
Belfast City Hospital
2016-2021
Queen Alexandra Hospital
2021
St Mary's Hospital
2009-2021
London School of Economics and Political Science
2021
St. Mary's Hospital
2009-2021
Ovarian cancer has a poor prognosis, with just 40% of patients surviving 5 years. We designed this trial to establish the effect early detection by screening on ovarian mortality.
Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which turn may promote formation reactive oxygen species, promoting DNA damage expression key regulatory cancer genes. As uncontrolled proliferation are hallmarks cancer, including epithelial ovarian (EOC), we hypothesized that inherited variation genes contributes EOC risk. Methods In total, samples were obtained from 14,525 case subjects...
Polycomb group proteins (PCGs) are involved in repression of genes that required for stem cell differentiation. Recently, it was shown promoters PCG target (PCGTs) 12-fold more likely to be methylated cancer than non-PCGTs. Age is the most important demographic risk factor cancer, and we hypothesized its carcinogenic potential may referred by irreversibly stabilizing features. To test this, analyzed methylation status over 27,000 CpGs mapping ∼14,000 whole blood samples from 261...
Ovarian cancer has a high case-fatality ratio, with most women not diagnosed until the disease is in its advanced stages. The United Kingdom Collaborative Trial of Cancer Screening (UKCTOCS) randomised controlled trial designed to assess effect screening on mortality. This report summarises outcome prevalence (initial) screen UKCTOCS.Between 2001 and 2005, total 202 638 post-menopausal aged 50-74 years were randomly assigned no treatment (control; n=101 359); annual CA125 (interpreted using...
BackgroundOvarian cancer continues to have a poor prognosis with the majority of women diagnosed advanced disease. Therefore, we undertook UK Collaborative Trial Ovarian Cancer Screening (UKCTOCS) determine if population screening can reduce deaths due We report on ovarian mortality after long-term follow-up in UKCTOCS.MethodsIn this randomised controlled trial, postmenopausal aged 50–74 years were recruited from 13 centres National Health Service trusts England, Wales, and Northern Ireland....
Background:Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, responsible for 13 000 deaths per year in United States. Risk prediction based on identifying germline mutations susceptibility genes could have a clinically significant impact reducing disease mortality.
Background Recent studies have shown that DNA methylation (DNAm) markers in peripheral blood may hold promise as diagnostic or early detection/risk for epithelial cancers. However, to date no study has evaluated the and predictive potential of such a large case control cohort on genome-wide basis. Principal Findings By performing DNAm profiling ovarian cancer cohort, we here demonstrate active significant impact pattern blood. Specifically, by measuring levels over 27,000 CpGs cells from 148...
Background: The implications of different adiposity measures on cardiovascular disease etiology remain unclear. In this article, we quantify and contrast causal associations central (waist-to-hip ratio adjusted for body mass index [WHRadjBMI]) general (body [BMI]) with cardiometabolic disease. Methods: Ninety-seven independent single-nucleotide polymorphisms BMI 49 WHRadjBMI were used to conduct Mendelian randomization analyses in 14 prospective studies supplemented coronary heart (CHD) data...
Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns TILs by histotype and relation to other clinical factors.
The aim of this study was to estimate the contribution deleterious mutations in RAD51B, RAD51C, and RAD51D genes invasive epithelial ovarian cancer (EOC) population a screening trial individuals at high risk cancer.
Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes not been well defined. As prevalence obesity has increased dramatically, and classification histology improved in last decade, we sought to examine association pooled analysis recent participating Ovarian Cancer Association Consortium. We evaluated between (recent, maximum young adulthood) cancer using original data from 15...
Abstract Breast, ovarian, and prostate cancers are hormone-related may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these totaling 112,349 cases 116,421 controls of European ancestry, all together in pairs, identified at P < 10−8 seven new cross-cancer loci: three associated with susceptibility to (rs17041869/2q13/BCL2L11;...
Purpose Cancer screening strategies have commonly adopted single-biomarker thresholds to identify abnormality. We investigated the impact of serial biomarker change interpreted through a risk algorithm on cancer detection rates. Patients and Methods In United Kingdom Collaborative Trial Ovarian Screening, 46,237 women, age 50 years or older underwent incidence by using multimodal strategy (MMS) in which annual serum antigen 125 (CA-125) was with ovarian (ROCA). Women were triaged ROCA:...
The increase in the worldwide incidence of endometrial cancer relates to rising obesity, falling fertility, and ageing population. Transvaginal ultrasound (TVS) is a possible screening test, but there have been no large-scale studies. We report performance TVS large cohort.We did nested case-control study postmenopausal women who underwent United Kingdom Collaborative Trial Ovarian Cancer Screening (UKCTOCS) following recruitment between April 17, 2001, Sept 29, 2005. Endometrial thickness...
Biomarkers for the early detection of pancreatic cancer are urgently needed. The primary objective this study was to evaluate whether increased levels serum CA19-9, CA125, CEACAM1, and REG3A present before clinical presentation assess performance combined markers prognosis.This nested case-control within UKCTOCS included 118 single 143 serial samples from 154 postmenopausal women who were subsequently diagnosed with 304 matched noncancer controls. Samples split randomly into independent...
High-throughput proteomic methods for disease biomarker discovery in human serum are promising, but concerns exist regarding reproducibility of results and variability introduced by sample handling. This study investigated the influence different preanalytic handling on surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) protein profiles prefractionated serum. We whether older collections with longer transit times yield useful profiles, sought to...
Objective To describe the factors that contributed to successful recruitment of more than 200 000 women UK Collaborative Trial Ovarian Cancer Screening, one largest ever randomised controlled trials. Design Descriptive study. Setting 13 NHS trusts in England, Wales, and Northern Ireland. Participants Postmenopausal aged 50-74; exclusion criteria included ovarian malignancy, bilateral oophorectomy, increased risk familial cancer, active non-ovarian participation other cancer screening Main...