Penelope M. Webb
A5015618057- Ovarian cancer diagnosis and treatment
- Cancer Risks and Factors
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Genetic Associations and Epidemiology
- Helicobacter pylori-related gastroenterology studies
- Nutrition, Genetics, and Disease
- Cancer survivorship and care
- Vitamin D Research Studies
- Esophageal Cancer Research and Treatment
- Estrogen and related hormone effects
- Nutritional Studies and Diet
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Childhood Cancer Survivors' Quality of Life
- Eosinophilic Esophagitis
- Reproductive Biology and Fertility
- Gastroesophageal reflux and treatments
- Global Public Health Policies and Epidemiology
- Family Support in Illness
QIMR Berghofer Medical Research Institute
2016-2025
The University of Queensland
2016-2025
Fox Chase Cancer Center
2024
Peter MacCallum Cancer Centre
2010-2023
Cancer Australia
2010-2023
Harvard University
2004-2023
Ovarian Cancer Research Alliance
2009-2023
Novartis (Switzerland)
2023
Jazz Pharmaceuticals (United States)
2023
Karyopharm Therapeutics (United States)
2023
The frequency of BRCA1 and BRCA2 germ-line mutations in women with ovarian cancer is unclear; reports vary from 3% to 27%. impact mutation on response requires further investigation understand its treatment planning clinical trial design.Women nonmucinous carcinoma (n = 1,001) enrolled onto a population-based, case-control study were screened for point large deletions both genes. Survival outcomes responses multiple lines chemotherapy assessed.Germ-line found 14.1% patients overall,...
Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this extends to all invasive histological subtypes or borderline tumours not clear. We undertook an international collaborative study assess the association between endometriosis and of cancer.
The cross sectional study describes the prevalence of infection with Helicobacter pylori as determined by a serodiagnostic assay in over 3000 asymptomatic subjects, two age groups 25-34 years and 55-64 years, from 17 geographically defined populations Europe, North Africa, America, Japan, using common protocol for blood collection serological testing. In all combined, was higher older group (62.4%) than younger (34.9%). There no difference between men women. Subjects education had...
<h3>Abstract</h3> <b>Abstract Objectives</b> : To relate the prevalence of infection with Helicobacter pylori in adults to their living conditions childhood indentify risk factors for infection. <b>Design</b> Prevalence study IgG antibodies H (>10 μg IgG/ml, determined by enzyme linked immunosorbent assay (ELISA)) and reported other socioeconomic childhood. <b>Setting</b> Three factories Stoke on Trent. <b>Subjects</b> 471 male volunteers aged 18 65 years. <b>Main outcome measures</b>...
Cancer is a leading cause of disease burden in Australia, particularly fatal burden, accounting for an estimated thirty percent deaths. Many cancers develop because exposure to lifestyle and environmental factors that are potentially modifiable. We aimed quantify the proportions numbers cancer deaths cases Australia 2013 attributable 20 modifiable eight broad groupings established causes cancer, namely: tobacco smoke (smoking second‐hand), dietary (low intake fruit, non‐starchy vegetables...
To measure the relative risks of adenocarcinomas oesophagus and gastro-oesophageal junction associated with measures obesity, their interactions age, sex, reflux symptoms smoking.Population-based case-control study in Australia.Patients (n = 367) or 426) were compared control participants 1580) sampled from a population register.Relative risk adenocarcinoma junction.Risks oesophageal increased monotonically body mass index (BMI) (p(trend) <0.001). Highest seen for BMI >or=40 kg/m2 (odds...
Previous studies that showed an association between smoking and adenocarcinomas of the esophagus esophagogastric junction were limited in their ability to assess differences by tumor site, sex, dose-response, duration cigarette cessation.We used primary data from 10 population-based case-control two cohort Barrett's Esophagus Esophageal Adenocarcinoma Consortium. Analyses restricted white non-Hispanic men women. Patients classified as having esophageal adenocarcinoma (n = 1540), junctional...
Abstract Accurately identifying patients with high-grade serous ovarian carcinoma (HGSOC) who respond to poly(ADP-ribose) polymerase inhibitor (PARPi) therapy is of great clinical importance. Here we show that quantitative BRCA1 methylation analysis provides new insight into PARPi response in preclinical models and cancer patients. The 12 HGSOC patient-derived xenografts (PDX) the rucaparib was assessed, variable dose-dependent responses observed chemo-naive BRCA1/2 -mutated PDX, no PDX...
Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes not been well defined. As prevalence obesity has increased dramatically, and classification histology improved in last decade, we sought to examine association pooled analysis recent participating Ovarian Cancer Association Consortium. We evaluated between (recent, maximum young adulthood) cancer using original data from 15...
Clinicopathologic data from a population-based endometrial cancer cohort, unselected for age or family history, were analyzed to determine the optimal scheme identification of patients with germline mismatch repair (MMR) gene mutations.Endometrial cancers 702 recruited into Australian National Endometrial Cancer Study (ANECS) tested MMR protein expression using immunohistochemistry (IHC) and MLH1 promoter methylation in MLH1-deficient cases. mutation testing was performed on DNA MMR-protein...
Abstract Objective To investigate whether supplementing older adults with monthly doses of vitamin D alters the incidence major cardiovascular events. Design Randomised, double blind, placebo controlled trial (the D-Health Trial). Computer generated permuted block randomisation was used to allocate treatments. Setting Australia from 2014 2020. Participants 21 315 participants aged 60-84 years at enrolment. Exclusion criteria were self-reported hypercalcaemia, hyperparathyroidism, kidney...
Abstract Chronic inflammation has been proposed as the possible causal mechanism that explains observed association between certain risk factors, such use of talcum powder (talc) in pelvic region and epithelial ovarian cancer. To address this issue we evaluated potential role chronic local development major subtypes Factors potentially linked to were examined an Australia‐wide case–control study comprising 1,576 women with invasive low malignant (LMP) tumours 1,509 population‐based controls....