A5074100708- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Liver physiology and pathology
- Genomic variations and chromosomal abnormalities
- Lung Cancer Treatments and Mutations
- Gastrointestinal Tumor Research and Treatment
- Transplantation: Methods and Outcomes
- Carbohydrate Chemistry and Synthesis
- Cancer-related gene regulation
- Proteoglycans and glycosaminoglycans research
- Renal cell carcinoma treatment
- Angiogenesis and VEGF in Cancer
- Renin-Angiotensin System Studies
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
The University of Queensland
2011-2022
Princess Alexandra Hospital
2010-2022
Mater Private Hospital
2000-2022
Flinders Medical Centre
2021
Mater Misericordiae Hospital
2015
QIMR Berghofer Medical Research Institute
1996-2012
Queensland Health
2012
Mater Research
2012
Princess Alexandra Hospital
1998-2010
Mater Health Services
2004
The functional roles of SNPs within the 8q24 gene desert in cancer phenotype are not yet well understood. Here, we report that CCAT2 , a novel long noncoding RNA transcript (lncRNA) encompassing rs6983267 SNP, is highly overexpressed microsatellite-stable colorectal and promotes tumor growth, metastasis, chromosomal instability. We demonstrate MYC miR–17–5p, miR–20a up-regulated by through TCF7L2-mediated transcriptional regulation. further identify physical interaction between TCF7L2...
We report patient outcomes from esophageal resection with respect to morbidity and cancer survival comparing open thoracotomy laparotomy (Open), a thoracoscopic/laparotomy approach (Thoracoscopic-Assisted) total thoracoscopic/laparoscopic (Total MIE).From prospective database of all patients managed the esophagus or esophagogastric junction, who had using one three techniques were analyzed assess postoperative variables, adequacy clearance, survival.The number for each procedure was as...
To measure the relative risks of adenocarcinomas oesophagus and gastro-oesophageal junction associated with measures obesity, their interactions age, sex, reflux symptoms smoking.Population-based case-control study in Australia.Patients (n = 367) or 426) were compared control participants 1580) sampled from a population register.Relative risk adenocarcinoma junction.Risks oesophageal increased monotonically body mass index (BMI) (p(trend) <0.001). Highest seen for BMI >or=40 kg/m2 (odds...
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large exome sequencing date have found recurrent loss-of-function mutations, oncogenic driving events been underrepresented. Here we use a combination whole-genome (WGS) single-nucleotide polymorphism-array profiling show that genomic catastrophes are frequent EAC, with almost third (32%, n=40/123)...
PATIENTS--Laparoscopic Nissen fundoplication was undertaken in 200 patients between 1991 and 1994. METHODS--Pre-operative assessment included symptom score, endoscopy, manometry, 24 hour pH monitoring of the oesophagus. Patients were evaluated at three 12 months after surgery with scoring 96 also underwent studies to six postoperatively. RESULTS--In first 100 median duration operation 155 minutes (range: 70-330), conversion rate laparotomy 7%, hospital stay days 2-57), total morbidity 16%....
Abstract Purpose: Despite significant progress in understanding the molecular pathology of pancreatic cancer and its precursor lesion: intraepithelial neoplasia (PanIN), there remain no molecules with proven clinical utility as prognostic or therapeutic markers. Here, we used oligonucleotide microarrays to interrogate mRNA expression tissue normal pancreas identify novel pathways dysregulated development progression cancer. Experimental Design: RNA was hybridized Affymetrix Genechip HG-U133...
Many serine proteases play important regulatory roles in complex biological systems, but only a few have been linked directly with capillary morphogenesis and angiogenesis. Here we provide evidence that protease activities, independent of the plasminogen activation cascade, are required for microvascular endothelial cell reorganization vitro. A homology cloning approach targeting conserved motifs present all proteases, was used to identify candidate involved these processes, revealed 5 genes...
This paper describes the cloning and characterization of a new member vascular endothelial growth factor (VEGF) gene family, which we have designated VRF for VEGF-related-factor. Sequencing cDNAs from human fetal brain library RT-PCR products normal tumor tissue cDNA pools indicate two alternatively spliced messages with open reading frames 621 564 bp, respectively. The predicted proteins differ at their carboxyl ends resulting shift in frame. Both isoforms show strong homology to VEGF amino...
Barrett's esophagus, a metaplastic precursor to esophageal adenocarcinoma, is becoming increasingly prevalent in many populations. Clinical studies suggest acid reflux causes esophagus; however, no population-based estimates of risk have been reported, and the role other health factors modifying unclear.We conducted case-control study Brisbane, Australia. Cases were 167 patients with histologically confirmed esophagus diagnosed between February December 2003. Age-matched sex-matched controls...
Fifty two patients with abnormal acid gastro-oesophageal reflux were studied by simultaneous oesophageal pH monitoring and continuous aspiration for 16 hours. Aspirates (from discrete hour periods) analysed volume, pH, bile acids (conjugated unconjugated), trypsin, pepsin. The results compared changes degree of oesophagitis. Patients oesophagitis had greater than those without, but stricture Barrett9s oesophagus similar to uncomplicated erosive Pepsin concentrations highest in particularly...
Although reflux of bile acids has been implicated in the pathogenesis oesophagitis, attempts to document this vivo have failed detect more than trace amounts acid oesophagus. To determine composition oesophageal refluxate, 45 patients with abnormal gastro-oesophageal oesophagitis and 10 controls had a size 14 Fr Salem sump tube positioned 5 cm above lower sphincter. Oesophageal contents were continuously aspirated collected aliquots every 2 h over 16 h. Fasting, postprandial, upright supine...
Abstract Background Oesophageal malignancy is a disease with poor prognosis. Oesophagectomy the mainstay of curative treatment but associated substantial morbidity and mortality. Although mortality rates have improved, incidence perioperative remains high. This study assessed impact postoperative on long-term outcomes. Methods A prospective database was designed for patients undergoing oesophagectomy from 1998 to 2011. An observational cohort performed these data, assessing intraoperative...
No AccessJournal of UrologyInvestigative Urology1 Apr 1997Vascular Endothelial Growth Factor Expression is Increased in Renal Cell Carcinoma David Nicol, Su-Ing Hii, Michael Walsh, Bin Teh, Les Thompson, Colin Kennett, and Gotley NicolDavid Nicol , HiiSu-Ing Hii WalshMichael Walsh TehBin Teh ThompsonLes Thompson KennettColin Kennett GotleyDavid View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65028-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack...
Abstract We applied whole-genome single-nucleotide polymorphism arrays to define a comprehensive genetic profile of 23 esophageal adenocarcinoma (EAC) primary tumor biopsies based on loss heterozygosity (LOH) and DNA copy number changes. Alterations were common, averaging 97 (range, 23–208) per tumor. LOH gains averaged 33 3–83) 31 11–73) tumor, respectively. Copy neutral events 27 7–57) EAC. noted 126 homozygous deletions (HD) across the EAC panel 0–11 in individual tumors). Frequent HDs...
The incidence of esophageal adenocarcinoma (EAC) has risen significantly over recent decades. Although survival improved, cure rates remain poor, with <20% patients surviving 5 years. This is the first study to explore methylome, transcriptome and ENCODE data characterize role methylation in EAC. We investigate genome-wide profile 250 samples including 125 EAC, 19 Barrett's esophagus (BE), 85 squamous 21 normal stomach. Transcriptome 70 (48 4 BE 18 esophagus) were used identify changes...