A5014097745- Statistical Methods in Clinical Trials
- Prostate Cancer Treatment and Research
- Ovarian cancer diagnosis and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Advanced Causal Inference Techniques
- Statistical Methods and Inference
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Colorectal Cancer Treatments and Studies
- Renal cell carcinoma treatment
- Radiopharmaceutical Chemistry and Applications
- Cancer Treatment and Pharmacology
- Advanced Radiotherapy Techniques
- Ethics in Clinical Research
- Cancer, Lipids, and Metabolism
- Urinary and Genital Oncology Studies
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- Hormonal and reproductive studies
- Intraperitoneal and Appendiceal Malignancies
MRC Clinical Trials Unit at UCL
2016-2025
University College London
2016-2025
Medical Research Council
2016-2025
Atal Bihari Vajpayee Indian Institute of Information Technology and Management
2017-2024
Tata Memorial Hospital
2024
Health Data Research UK
2022-2024
Homi Bhabha National Institute
2024
Mid Yorkshire Hospitals NHS Trust
2023
Pinderfields Hospital
2023
Australian National University
2022
Meta-analyses aim to provide a full and comprehensive summary of related studies which have addressed similar question. When the involve time event (survival-type) data most appropriate statistics use are log hazard ratio its variance. However, these not always explicitly presented for each study. In this paper number methods extracting estimates in variety situations presented. Use should improve efficiency reliability meta-analyses published literature with survival-type endpoints. © 1998...
Men with high serum prostate specific antigen usually undergo transrectal ultrasound-guided biopsy (TRUS-biopsy). TRUS-biopsy can cause side-effects including bleeding, pain, and infection. Multi-parametric magnetic resonance imaging (MP-MRI) used as a triage test might allow men to avoid unnecessary improve diagnostic accuracy.
Angiogenesis plays a role in the biology of ovarian cancer. We examined effect bevacizumab, vascular endothelial growth factor inhibitor, on survival women with this disease.
BackgroundLong-term hormone therapy has been the standard of care for advanced prostate cancer since 1940s. STAMPEDE is a randomised controlled trial using multiarm, multistage platform design. It recruits men with high-risk, locally advanced, metastatic or recurrent who are starting first-line long-term therapy. We report primary survival results three research comparisons testing addition zoledronic acid, docetaxel, their combination to versus alone.MethodsStandard was at least 2 years;...
Abiraterone acetate plus prednisolone improves survival in men with relapsed prostate cancer. We assessed the effect of this combination starting long-term androgen-deprivation therapy (ADT), using a multigroup, multistage trial design.
Modelling of censored survival data is almost always done by Cox proportional-hazards regression. However, use parametric models for such may have some advantages. For example, non-proportional hazards, a potential difficulty with models, sometimes be handled in simple way, and visualization the hazard function much easier. Extensions Weibull log-logistic are proposed which natural cubic splines used to smooth baseline log cumulative odds failure functions. Further extensions allow effects...
BackgroundBased on previous findings, we hypothesised that radiotherapy to the prostate would improve overall survival in men with metastatic cancer, and benefit be greatest patients a low burden. We aimed compare standard of care for without radiotherapy.MethodsWe did randomised controlled phase 3 trial at 117 hospitals Switzerland UK. Eligible had newly diagnosed cancer. randomly allocated open-label 1:1 ratio (control group) or (radiotherapy group). Randomisation was stratified by...
Ovarian cancer has a poor prognosis, with just 40% of patients surviving 5 years. We designed this trial to establish the effect early detection by screening on ovarian mortality.
This article presents the long-term results of international multicenter randomized trial that investigated use neoadjuvant cisplatin, methotrexate, and vinblastine (CMV) chemotherapy in patients with muscle-invasive urothelial cancer bladder treated by cystectomy and/or radiotherapy. Nine hundred seventy-six were recruited between 1989 1995, median follow-up is now 8.0 years.This was a phase III either no or three cycles CMV.The previously reported possible survival advantage CMV...
Ovarian cancer has a high case-fatality ratio, with most women not diagnosed until the disease is in its advanced stages. The United Kingdom Collaborative Trial of Cancer Screening (UKCTOCS) randomised controlled trial designed to assess effect screening on mortality. This report summarises outcome prevalence (initial) screen UKCTOCS.Between 2001 and 2005, total 202 638 post-menopausal aged 50-74 years were randomly assigned no treatment (control; n=101 359); annual CA125 (interpreted using...
Designs and analyses of clinical trials with a time-to-event outcome almost invariably rely on the hazard ratio to estimate treatment effect implicitly, therefore, proportional hazards assumption. However, results some recent indicate that there is no guarantee assumption will hold. Here, we describe use restricted mean survival time as possible alternative tool in design analysis these trials. The measure average from 0 specified point, may be estimated area under curve up point. We...
The ICON7 trial previously reported improved progression-free survival in women with ovarian cancer the addition of bevacizumab to standard chemotherapy, greatest effect patients at high risk disease progression. We report final overall results trial.ICON7 was an international, phase 3, open-label, randomised undertaken 263 centres 11 countries across Europe, Canada, Australia and New Zealand. Eligible adult newly diagnosed that either high-risk early-stage (International Federation...
Preface to the First Edition. Second Chapter 1: Introduction and Review of Statistical Concepts. 2: Survival Curves. 3: Comparison 4: Parametric Modelling. 5: Cox's Proportional Hazards Model. 6: Selecting Variables within a Cox 7: Extensions 8: Prognostic Indices. 9: Sample Sizes. 10: Further Topics. References. Tables. Index.
Statistical issues in conducting randomized trials include the choice of a sample size, whether to stop trial early and appropriate analysis interpretation results. At each these stages, evidence external is useful, but generally such introduced an unstructured informal manner. We argue that Bayesian approach allows formal basis for using addition provides rational way dealing with as ethics randomization, show treatment equivalence, monitoring accumulating data prediction consequences...
BackgroundWhole brain radiotherapy (WBRT) and dexamethasone are widely used to treat metastases from non-small cell lung cancer (NSCLC), although there have been no randomised clinical trials showing that WBRT improves either quality of life or overall survival. Even after treatment with WBRT, the prognosis this patient group is poor. We aimed establish whether could be omitted without a significant effect on survival life.MethodsThe Quality Life Treatment for Brain Metastases (QUARTZ) study...
The Gynecological Cancer Intergroup (GCIG) has previously reached consensus regarding the criteria that should be used in clinical trial protocols to define progression-free survival after first-line therapy as well response treatment recurrent disease using serum marker CA 125 and specified situations where these used. However, publications did not include detailed definitions, nor were they written accommodate new version of Response Evaluation Criteria In Solid Tumors (RECIST) (version...