A5057313839- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related gene regulation
- Testicular diseases and treatments
- BRCA gene mutations in cancer
- Neuroendocrine Tumor Research Advances
- Kruppel-like factors research
- Protease and Inhibitor Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Multiple and Secondary Primary Cancers
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- RNA modifications and cancer
- Cell death mechanisms and regulation
- Ectopic Pregnancy Diagnosis and Management
- Colorectal and Anal Carcinomas
Tokeidai Memorial Hospital
2023
Cardiovascular Center Hokkaido Ohno Hospital
2019-2022
Hokkaido hospital
2012-2013
Keiyukai Sapporo Hospital
2012
Sapporo City General Hospital
2011
Sapporo Medical University
1996-2007
Japan Clinical Cancer Research Organization
2004-2005
Beijing Obstetrics and Gynecology Hospital
2004
University of Maryland, Baltimore
2003
Shiga University
2003
The Gynecological Cancer Intergroup (GCIG) has previously reached consensus regarding the criteria that should be used in clinical trial protocols to define progression-free survival after first-line therapy as well response treatment recurrent disease using serum marker CA 125 and specified situations where these used. However, publications did not include detailed definitions, nor were they written accommodate new version of Response Evaluation Criteria In Solid Tumors (RECIST) (version...
A review of 255 patients with epithelial ovarian carcinoma revealed that metastases consistent Stage IV disease developed in 97 (38.0%) at some time during the natural history their disease. Malignant pleural effusions 63 (24.7%), and median survival (from diagnosis effusion) was 6 months. Parenchymal liver 24 (9.4%; survival, 5 months); parenchymal lung 18 (7.1%; 8 distant lymph node 9 subcutaneous nodules nine (3.5%; 12 a malignant pericardial effusion six (2.4%; 2.3 central nervous system...
<i>Objective:</i> The aim of this study was to evaluate the clinicopathological features uterine sarcoma in Hokkaido, Japan, between 1990 and 1999, identify prognostic factors patients with such malignancies area period. <i>Methods:</i> One hundred six histologically proven were evaluated retrospectively. <i>Results:</i> 93.5% carcinosarcoma (CS) diagnosed as having malignant disease preoperatively, while 65% those leiomyosarcoma (LMS) 75% endometrial...
Abstract Endometrial and ovarian carcinomas are common among women belonging to hereditary nonpolyposis colorectal carcinoma (HNPCC) families; tumors developing in them characterized by genetic instability due an inherited dysfunction of the DNA‐mismatch‐repair system. To clarify role similar factors sporadic forms gynecological tumors, we examined 77 endometrial 68 for replication error (RER) at five microsatellite loci. RER‐positive phenotypes two or more loci were observed 18 carcinomas,...
To investigate the contribution of β‐catenin to development endometrial carcinoma, we searched for genetic alterations gene in primary carcinomas. Mutational analysis exon 3 gene, encoding serine/threonine residues GSK‐3β phosphorylation, was performed 35 tumors. Nucleotide sequencing revealed that 5 tumors (5/35, 14%) contained mutations (S33C, S37C, S37F, T41A) altered potential phosphorylation sites. Each resulted substitution have been implicated down‐regulation through by kinase....
Recent studies demonstrated that a single guanine insertion polymorphism in matrix metalloprotease‐1 promoter created an Ets binding site and affected the elevation of transcriptional level metalloproteinase‐1 (MMP‐1). Furthermore, tumor cell lines derived from melanoma breast cancer, incidence 2G/2G genotype was significantly higher than normal population. To evaluate contribution this endometrial carcinomas, we genotyped 100 carcinomas then analyzed immunoexpression MMP‐1 these carcinomas....
The purpose of this work was to explore the role epigenetic inactivation apoptotic pathways in ovarian cancer by examining DNA methylation and expression status four proapoptotic genes primary cancers cell lines correlate those findings with clinicopathological features patients.Genomic isolated from 15 lines, 80 specimens, 4 normal ovary specimens using phenol-chloroform extraction. evaluated combined bisulfite restriction analysis, gene reverse transcription-PCR, histone acetylation...
Ovarian clear cell carcinoma (CCC) is regarded as grade 3 tumor, and the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines recommend adjuvant chemotherapy for tumor even at stage IA. However, CCC often showed chemo-resistant phenotype, effect of still remained uncertain.Clear cases treated collaborating institutions during period 1992-2005 were retrospectively identified. After a central pathological review, survival analysis was estimated by Kaplan-Meier method,...
To investigate the contribution of β‐catenin gene to development ovarian carcinomas, mutational analysis exon 3 was conducted. We analyzed 61 primary consisting 49 non‐endometrioid‐type and 12 endometrioid‐type tumors, for genetic alteration gene. Five carcinomas showed mutations (S37C, T41I, T41A), including 4 (33%) tumors 1 (14%) 7 mucinous‐type tumors. All these altered at serine/threonine residues that are potential sites GSK3‐β phosphorylation. detected no with interstitial deletion...
Microsatellite instability, monitored by replication error (RER), bas been observed in both sporadic and hereditary types of endometrial carcinoma. In the tumors, this instability is considered to be caused a germline defect DNA mismatch‐repair system. We previously reported that nearly one‐quarter carcinomas examined revealed an RER‐positive phenotype at multiple microsatellite loci. To investigate role genetic alterations genes carcinomas, we screened 18 RER(+) for mutations hMLH1 hMSH2 ....
Objective Cervical cancer is responsible for more than a quarter of million deaths globally each year, mostly in developing countries, making therapeutic advances all health care settings top priority. The Gynecologic Cancer InterGroup (GCIG) worldwide collaboration leading national research groups that develops and promotes multinational trials gynecologic cancer. In recognition the pressing need action, GCIG convened an international meeting with expert representation from selected large...
Transcription factor 2 gene (TCF2) encodes hepatocyte nuclear 1β (HNF1β), a transcription associated with development and metabolism. Mutation of TCF2 has been observed in renal cell cancer, by screening aberrantly methylated genes, we have now identified as target for epigenetic inactivation ovarian cancer. was 53% cancer lines 26% primary cancers, resulting loss the gene's expression. expression restored treating cells methyltransferase inhibitor, 5-aza-2′deoxycitidine (5-aza-dC). In...