Henry C Kitchener
A5008419054- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Genital Health and Disease
- Global Cancer Incidence and Screening
- Hepatitis B Virus Studies
- Estrogen and related hormone effects
- Reproductive tract infections research
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Immunotherapy and Immune Responses
- Intraperitoneal and Appendiceal Malignancies
- Cancer Risks and Factors
- Molecular Biology Techniques and Applications
- BRCA gene mutations in cancer
- Reproductive Biology and Fertility
- Cancer-related Molecular Pathways
- Gynecological conditions and treatments
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Patient-Provider Communication in Healthcare
- Epigenetics and DNA Methylation
- Vaccine Coverage and Hesitancy
- Metabolism, Diabetes, and Cancer
St Mary's Hospital
2012-2023
University of Manchester
2014-2023
Cancer Research UK Manchester Institute
2013-2022
Manchester Academic Health Science Centre
2009-2021
Salford Royal Hospital
2021
Manchester University NHS Foundation Trust
2021
Salford Royal NHS Foundation Trust
2021
NIHR Manchester Biomedical Research Centre
2010-2019
Pennine Acute Hospitals NHS Trust
2018
Anna Needs Neuroblastoma Answers
2017
The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy (CTRT) versus alone (RT) for women with high-risk endometrial cancer (EC). Because Genome Atlas defined an EC molecular classification strong prognostic value, we prognosis impact each subgroup using tissue samples from PORTEC-3 participants.Paraffin-embedded tissues 423 consenting patients...
BackgroundAlthough women with endometrial cancer generally have a favourable prognosis, those high-risk disease features are at increased risk of recurrence. The PORTEC-3 trial was initiated to investigate the benefit adjuvant chemotherapy during and after radiotherapy (chemoradiotherapy) versus pelvic alone for cancer.MethodsPORTEC-3 an open-label, international, randomised, phase 3 involving 103 centres in six clinical trials collaborating Gynaecological Cancer Intergroup. Eligible had...
The PORTEC-3 trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy versus pelvic alone for women with high-risk endometrial cancer. We updated analysis to investigate patterns recurrence did a post-hoc survival analysis.In multicentre randomised phase 3 trial, cancer were eligible if they had International Federation Gynaecology Obstetrics (FIGO) 2009 stage I, endometrioid grade deep myometrial invasion or lymphovascular space invasion, both; II III disease; I-III...
There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best manage the risk of in syndrome. The Manchester International Consensus Group was convened April 2017 address this unmet need. aim develop clear and comprehensive guidance regarding management sequelae based on existing evidence expert opinion medical professionals patients.
Abstract Objective To provide the first report on main outcomes from prevalence and incidence rounds of a large pilot routine primary high risk human papillomavirus (hrHPV) testing in England, compared with contemporaneous liquid based cytology screening. Design Observational study. Setting The English Cervical Screening Programme. Participants 578 547 women undergoing cervical screening care between May 2013 December 2014, follow-up until 2017; 183 970 (32%) were screened hrHPV testing....
<h3>Abstract</h3> <b>Objective</b>: To evaluate the effectiveness and safety of endometrial laser ablation transcervical resection endometrium compared with hysterectomy in surgical treatment women dysfunctional uterine bleeding. <b>Design</b>: Prospective randomised controlled trial. <b>Setting</b>: Gynaecology department a large teaching hospital. <b>Subjects</b>: 204 who would otherwise have been undergoing for menorrhagia were recruited between August 1990 March 1992 randomly allocated...