A5031370921- Fibroblast Growth Factor Research
- Endometrial and Cervical Cancer Treatments
- Kruppel-like factors research
- Cancer Genomics and Diagnostics
- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- Ovarian cancer diagnosis and treatment
- melanin and skin pigmentation
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- PI3K/AKT/mTOR signaling in cancer
- Cell death mechanisms and regulation
- Wnt/β-catenin signaling in development and cancer
- Eosinophilic Disorders and Syndromes
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Arctic and Antarctic ice dynamics
- Prostate Cancer Treatment and Research
- Endometriosis Research and Treatment
- CAR-T cell therapy research
Queensland University of Technology
2015-2024
Translational Research Institute
2016-2024
Translational Genomics Research Institute
2005-2023
Queen's University
2023
Princess Alexandra Hospital
2021
The University of Queensland
2001-2020
Mater Research
2020
Harvard University Press
2012-2018
New York University
2012
National Institutes of Health
2000-2006
The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy (CTRT) versus alone (RT) for women with high-risk endometrial cancer (EC). Because Genome Atlas defined an EC molecular classification strong prognostic value, we prognosis impact each subgroup using tissue samples from PORTEC-3 participants.Paraffin-embedded tissues 423 consenting patients...
Standard molecular classification of endometrial cancers (EC) is now endorsed by the WHO and identifies p53-abnormal (p53abn) EC as subgroup with poorest prognosis most likely to benefit from adjuvant chemo(radio)therapy. P53abn are POLE wildtype, mismatch repair proficient show abnormal immunohistochemical (IHC) staining for p53. Correct interpretation routinely performed p53 IHC has therefore become paramount importance. We aimed comprehensively investigate patterns their relation...
Abstract Patients with metastatic melanoma or multiple myeloma have a dismal prognosis because these aggressive malignancies resist conventional treatment. A promising new oncologic approach uses molecularly targeted therapeutics that overcomes apoptotic resistance and, at the same time, achieves tumor selectivity. The unexpected selectivity of proteasome inhibition for inducing apoptosis in cancer cells, but not normal prompted us to define mechanism action this class drugs, including Food...
Abstract Purpose: Hepatocellular carcinoma (HCC) is the fifth most common primary neoplasm; surgery only curative option but 5-year survival rates are 25% to 50%. Vascular endothelial growth factor (VEGF) and fibroblast (FGF) known be involved in neovascularization of HCC. Therefore, agents that target these pathways may effective treatment The aim this study was determine antineoplastic activity brivanib alaninate, a dual inhibitor VEGF receptor (VEGFR) FGF (FGFR) signaling pathways....
Mutations in multiple oncogenes including KRAS, CTNNB1, PIK3CA and FGFR2 have been identified endometrial cancer. The aim of this study was to provide insight into the clinicopathological features associated with patterns mutation these genes, a necessary step planning targeted therapies for 466 endometrioid tumors were tested mutations FGFR2, PIK3CA. relationships between status, tumor microsatellite instability (MSI) overall survival (OS) disease-free (DFS) evaluated using Kaplan-Meier...
Abstract KRAS activation and PTEN inactivation are frequent events in endometrial tumorigenesis, occurring 10% to 30% 26% 80% of cancers, respectively. Because we have recently shown activating mutations fibroblast growth factor receptor 2 (FGFR2) 16% endometrioid sought determine the genetic context which FGFR2 occur. Analysis 116 primary cancers revealed that were mutually exclusive, whereas seen concomitantly with mutations. Here, show shRNA knockdown or treatment a pan-FGFR inhibitor,...
We sought to identify fibroblast growth factor receptor 2 (FGFR2) kinase domain mutations that confer resistance the pan-FGFR inhibitor, dovitinib, and explore mechanism of action drug-resistant mutations. cultured BaF3 cells overexpressing FGFR2 in high concentrations dovitinib identified 14 dovitinib-resistant mutations, including N550K mutation observed 25% FGFR2mutant endometrial cancers (ECs). Structural biochemical vitro analyses, together with proliferation assays, showed elevate...
High-risk endometrial cancer (EC) is an aggressive disease for which new therapeutic options are needed. Aims of this study were to validate the enhanced immune response in highly mutated ECs and explore profiles other EC subgroups. We evaluated infiltration 116 high-risk from TransPORTEC consortium, previously classified into four molecular subtypes: (i) ultramutated POLE exonuclease domain-mutant (POLE-mutant); (ii) hypermutated microsatellite unstable (MSI); (iii) p53-mutant; (iv) no...
The overall 5-year survival for melanoma is 91%. However, if distant metastasis occurs (stage IV), cure rates are < 15%. Hence, detection in earlier stages (stages I-III) maximises the chances of patient survival. We measured expression a panel 17 microRNAs (miRNAs) (MELmiR-17) tissues III; n = 76 and IV; 10) serum samples (collected from controls with no melanoma, 130; patients I/II, 86; III, 50; IV, 119)) obtained biobanks Australia Germany. In tissues, members 'MELmiR-17' were found to be...
To identify 'melanoma-specific' microRNAs (miRNAs) we used an unbiased microRNA profiling approach to comprehensively study cutaneous melanoma in relation other solid malignancies, which revealed 233 differentially expressed (≥ 2 fold, p < 0.05) miRNAs. Among the top 20 most significantly different miRNAs was hsa-miR-514a-3p. miR-514a is a member of cluster (miR-506-514) involved initiating melanocyte transformation and promotion growth. We found 38/55 (69%) cell lines but only 1/34 (3%)...
This paper describes the cloning and characterization of a new member vascular endothelial growth factor (VEGF) gene family, which we have designated VRF for VEGF-related-factor. Sequencing cDNAs from human fetal brain library RT-PCR products normal tumor tissue cDNA pools indicate two alternatively spliced messages with open reading frames 621 564 bp, respectively. The predicted proteins differ at their carboxyl ends resulting shift in frame. Both isoforms show strong homology to VEGF amino...
Once melanoma metastasizes, no effective treatment modalities prolong survival in most patients. This notorious refractoriness to therapy challenges investigators identify agents that overcome resistance apoptosis. Whereas many pathways contribute the death-defying phenotype melanoma, a defect apoptotic machinery previously highlighted inactivation of Apaf-1, an apoptosome component engaged after mitochondrial damage. During studies involving Notch signaling we observed gamma-secretase...
Abstract We report that 10% of melanoma tumors and cell lines harbor mutations in the fibroblast growth factor receptor 2 (FGFR2) gene. These novel include three truncating 20 missense occurring at evolutionary conserved residues FGFR2 as well among all four FGFRs. The mutation spectrum is characteristic those induced by UV radiation. Mapping these onto known crystal structures followed vitro vivo studies show result loss function through several distinct mechanisms, including ligand binding...
The importance of mitogen-activated protein kinase signaling in melanoma is underscored by the prevalence activating mutations N-Ras and B-Raf, yet clinical development inhibitors this pathway has been largely ineffective, suggesting that alternative oncogenes may also promote melanoma. Notch an interesting candidate only correlated with progression; a thorough assessment tumor-initiating effects activated on human melanocytes would clarify mounting correlative evidence perhaps identify...