A5021122880- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Advanced Breast Cancer Therapies
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer Risks and Factors
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Cancer survivorship and care
- Cervical Cancer and HPV Research
- BRCA gene mutations in cancer
- Sarcoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Bone health and treatments
- Medical Imaging Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Cancer Research and Treatments
- Patient-Provider Communication in Healthcare
- Dietary Effects on Health
- Global Cancer Incidence and Screening
Leiden University Medical Center
2016-2025
University Medical Center
2015-2024
Loyola University Medical Center
2013-2023
University Medical Center Utrecht
2018-2023
Leiden University
2010-2023
Swiss Group For Clinical Cancer Research
2023
Philips (Netherlands)
2016-2023
NXP (Netherlands)
2023
Medisch Centrum Haaglanden
2022
International Breast Cancer Study Group
2019-2021
Current therapy of gynecologic malignancies consists platinum-containing chemotherapy. Resistance to is associated with increased levels interleukin (IL)-6 and prostaglandin E2 (PGE(2)), 2 inflammatory mediators known skew differentiation monocytes tumor-promoting M2 macrophages. We investigated the impact cisplatin carboplatin on 10 different cervical ovarian cancer cell lines as well ability tumor cells affect function cocultured in vitro. Treatment or potency induce IL-10-producing...
Abstract BACKGROUND: Pigmented villonodular synovitis (PVNS) (also known as diffuse‐type giant cell tumor) and tenosynovial tumors (TGCT) are rare, usually benign neoplasms that affect the synovium tendon sheaths in young adults. These driven by overexpression of colony stimulating factor‐1 (CSF1). CSF1 is expressed a minority tumor cells, which, turn attract non‐neoplastic inflammatory cells express receptor (CSF1R) through paracrine effect. METHODS: Imatinib mesylate (IM) blocks CSF1R,...
Abstract Short-term fasting protects tumor-bearing mice against the toxic effects of chemotherapy while enhancing therapeutic efficacy. We randomized 131 patients with HER2-negative stage II/III breast cancer, without diabetes and a BMI over 18 kg m −2 , to receive either mimicking diet (FMD) or their regular for 3 days prior during neoadjuvant chemotherapy. Here we show that there was no difference in toxicity between both groups, despite fact dexamethasone omitted FMD group. A...
Preclinical evidence shows that short-term fasting (STF) protects healthy cells against side effects of chemotherapy and makes cancer more vulnerable to it. This pilot study examines the feasibility STF its on tolerance in a homogeneous patient group with early breast (BC). Eligible patients had HER2-negative, stage II/III BC. Women receiving (neo)-adjuvant TAC (docetaxel/doxorubicin/cyclophosphamide) were randomized fast 24 h before after commencing chemotherapy, or eat according guidelines...
Therapeutic vaccination against HPV16 is effective with chemotherapy for advanced cervical cancer patients.
The optimal duration of extended endocrine therapy beyond five years after initial aromatase inhibitor-based adjuvant for postmenopausal women with hormone receptor-positive breast cancer is still unknown. Therefore, we conducted a clinical trial to compare two different durations.In the randomized phase III IDEAL trial, patients were randomly allocated either 2.5 or letrozole any therapy. primary end point was disease free survival (DFS), and secondary points overall (OS), distant...
Regulatory T cell (Treg)-mediated immunosuppression is considered a major obstacle for successful cancer immunotherapy. The association between clinical outcome and Tregs being studied extensively in trials, but unfortunately, no consensus has been reached about (a) the markers (b) gating strategy required to define human this context, making it difficult draw final conclusions. Therefore, we have organized an international workshop on detection functional testing of with leading experts...
Prospective data on the risk of recurrence among women with hormone receptor–positive early breast cancer who temporarily discontinue endocrine therapy to attempt pregnancy are lacking. Download a PDF Research Summary. We conducted single-group trial in which we evaluated temporary interruption adjuvant young previous cancer. Eligible were 42 years age or younger; had stage I, II, III disease; received for 18 30 months; and desired pregnancy. The primary end point was number events (defined...
Standard molecular classification of endometrial cancers (EC) is now endorsed by the WHO and identifies p53-abnormal (p53abn) EC as subgroup with poorest prognosis most likely to benefit from adjuvant chemo(radio)therapy. P53abn are POLE wildtype, mismatch repair proficient show abnormal immunohistochemical (IHC) staining for p53. Correct interpretation routinely performed p53 IHC has therefore become paramount importance. We aimed comprehensively investigate patterns their relation...
This study determines the prognostic value of luminal-like subtype in patients with hormone receptor-positive breast cancer and explores whether efficacy extended anastrozole therapy differs between luminal A-like versus B-like tumours. The phase III DATA (NCT00301457) examined 6 3 years postmenopausal women early-stage who had received 2-3 tamoxifen. Patients available formalin-fixed paraffin-embedded tissue blocks were identified classified by immunohistochemical subtype. Distant...
Abstract Background Giant cell tumour of bone (GCTB) is an expansile osteolytic which contains numerous osteoclast-like giant cells. GCTB frequently recurs and can produce metastatic lesions in the lungs. Bisphosphonates are anti-resorptive drugs act mainly on osteoclasts. Method In this study, we have examined clinical radiological outcomes treatment with aminobisphosphonates 25 cases aggressive primary, recurrent derived from four European centres. We also analysed vitro inhibitory effect...
Purpose Previous studies have suggested an association between metformin use and improved outcome in patients with diabetes breast cancer. In the current study, we aimed to explore this human epidermal growth factor receptor 2 (HER2 ) -positive primary cancer context of a large, phase III adjuvant trial. Patients Methods The ALTTO trial randomly assigned HER2-positive receive 1 year either trastuzumab alone, lapatinib their sequence, or combination. substudy, evaluated whether at study...