Hein B.A.C. Stockmann
A5016313024- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Appendicitis Diagnosis and Management
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- Enhanced Recovery After Surgery
- Anorectal Disease Treatments and Outcomes
- Cancer Immunotherapy and Biomarkers
- Esophageal and GI Pathology
- Biliary and Gastrointestinal Fistulas
- Gallbladder and Bile Duct Disorders
- Surgical Simulation and Training
- Organ Transplantation Techniques and Outcomes
- Xenotransplantation and immune response
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- Surgical site infection prevention
- Cancer survivorship and care
- Liver physiology and pathology
- Immunotherapy and Immune Responses
Spaarne Ziekenhuis
2016-2024
Spaarne Gasthuis
2015-2024
Amsterdam University Medical Centers
2021-2023
Medisch Spectrum Twente
2023
Radboud University Nijmegen
2022-2023
Radboud University Medical Center
2022-2023
University of Amsterdam
2021
St. Antonius Ziekenhuis
2020
Evangelisches Krankenhaus Kalk
2018
Data Harbor (United States)
2015
Abstract Background Antibiotics are advised in most guidelines on acute diverticulitis, despite a lack of evidence to support their routine use. This trial compared the effectiveness strategy with or without antibiotics for first episode uncomplicated diverticulitis. Methods Patients CT-proven, primary, left-sided, uncomplicated, diverticulitis were included at 22 clinical sites Netherlands, and assigned randomly an observational antibiotic treatment strategy. The primary endpoint was time...
Abstract Background Infectious complications and anastomotic leakage affect approximately 30 per cent of patients after colorectal cancer surgery. The aim this multicentre randomized trial was to investigate whether selective decontamination the digestive tract (SDD) reduces these elective Methods effectiveness SDD evaluated in a multicentre, open-label RCT six centres Netherlands. Patients with scheduled for curative surgery primary anastomosis were eligible. Oral colistin, tobramycin...
Traditionally uncomplicated acute diverticulitis was routinely treated with antibiotics, although evidence for this strategy lacking. Recently, two randomized clinical trials (AVOD trial and DIABOLO trial) published short-term results of omitting antibiotics compared to routine antibiotic treatment. Both showed no significant differences regarding recovery from the initial episode, as well rates complicated or recurrent sigmoid resection. However, both studies a trend higher resection in...
Recently, excellent results are reported on laparoscopic lavage in patients with purulent perforated diverticulitis as an alternative for sigmoidectomy and ostomy.The objective of this study is to determine whether LaparOscopic LAvage drainage a safe effective treatment peritonitis (LOLA-arm) the optimal resectional strategy or faecal (DIVA-arm: DIVerticulitis: sigmoidresection without Anastomosis).In multicentre randomised trial all included. Upon laparoscopy, treated drainage, Hartmann's...
Conservative treatment of mild colonic diverticulitis usually consists observation, restriction oral intake, intravenous fluids and antibiotics. The beneficiary effect antibiotics remains unclear. aim this study is to evaluate the need for in diverticulitis.A retrospective case-control was performed 272 patients with admitted two hospitals distinctly different regimes concerning antibiotic use.A total 191 were treated without 81 Groups comparable at baseline respect age, sex, comorbidity,...
Abstract Background Discrimination between simple and perforated appendicitis in patients with suspected may help to determine the therapy, timing of surgery risk complications. The aim this study was estimate accuracy magnetic resonance imaging (MRI) distinguishing appendicitis, compare MRI against ultrasound selected additional (conditional) use computed tomography (CT). Methods Patients clinically were identified prospectively at emergency department six hospitals. Consenting underwent...
Background: The increasing sub-classification of cancer patients due to more detailed molecular classification tumors, and limitations current trial designs, require innovative research designs. We present the design, governance standing three comprehensive nationwide cohorts including pancreatic, esophageal/gastric, colorectal (NCT02070146). Multidisciplinary collection clinical data, tumor tissue, blood samples, patient-reported outcome (PRO) measures with a coverage, provides...
Transanal total mesorectal excision (TaTME) is a new complex technique with potential to improve the quality of surgical for patients mid and low rectal cancer. The procedure technically challenging has shown be associated relative long learning curve which might hamper widespread adoption. Therefore, national structured training pathway TaTME been set up in Netherlands allow safe implementation. aim this study was monitor safety efficacy program 12 centers. Short-term outcomes first ten...
The prognostic role of pericolic or perirectal isolated tumor deposits (ITDs) in node-negative colorectal cancer (CRC) patients is unclear. Rules to define ITDs as regional lymph node metastases changed subsequent editions the TNM staging without substantial evidence. Aim this study was investigate correlation between and disease recurrence stage II III CRC patients.The medical files 870 were reviewed. Number, size, shape, location pattern all examined relation involvement vascular...
Lymph node (LN) yield in colon cancer resection specimens is an important indicator of treatment quality and has especially early-stage patients therapeutic implications. However, underlying disease mechanisms, such as microsatellite instability (MSI), may also influence LN yield, MSI tumors are known to exhibit more prominent lymphocytic antitumor reactions. The aim the present study was investigate association status, recurrence rate cancer.
Conservative treatment of uncomplicated or mild diverticulitis usually includes antibiotic therapy. It is, however, uncertain whether patients with acute indeed benefit from antibiotics. In most guidelines issued by professional organizations antibiotics are considered mandatory in the diverticulitis. This advice lacks evidence and is merely based on experts' opinion. Adverse effects use well known, including allergic reactions, development bacterial resistance to other side-effects. A...
Microsatellite instability (MSI) has been associated with favourable survival in early stage colorectal cancer (CRC) compared to microsatellite stable (MSS) CRC. The BRAF V600E mutation worse MSS This occurs 40% of MSI CRC and it is unclear whether confers this setting. prognostic value KRAS mutations both remains unclear. We examined the effect on II III colon patients. exon 15 2–3 status was assessed 143 ( n = 85) 58) cancers by high resolution melting analysis sequencing. relation between...
<h3>Background</h3> Immune regulated pathways influence both breast cancer (BrC) development and response to (neo)adjuvant chemotherapy. The sentinel lymph node (SLN), as the first metastatic site, is also site where BrC-induced suppression of immune effector subsets occurs. Since intricate knowledge phenotypic functional status these lacking, we set out map landscape BrC SLN. <h3>Methods</h3> Viable LN cells from SLN (<i>n</i> = 58) were used for detailed flowcytometry-assisted mapping in a...