A5029196683- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Gastroesophageal reflux and treatments
- Metastasis and carcinoma case studies
- Cardiac, Anesthesia and Surgical Outcomes
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Dysphagia Assessment and Management
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Enhanced Recovery After Surgery
- Radiomics and Machine Learning in Medical Imaging
- Multiple and Secondary Primary Cancers
- Nutrition and Health in Aging
- Delphi Technique in Research
- Tracheal and airway disorders
- Global Cancer Incidence and Screening
- Surgical Simulation and Training
- Neuroendocrine Tumor Research Advances
- Wnt/β-catenin signaling in development and cancer
Erasmus University Rotterdam
2016-2025
Erasmus MC
2016-2025
Erasmus MC Cancer Institute
2004-2025
Yahoo (United Kingdom)
2024
Maastricht University
2024
The Netherlands Cancer Institute
2024
University of Birmingham
2017-2022
Queen Elizabeth Hospital Birmingham
2022
John Wiley & Sons (United Kingdom)
2019-2020
Cleveland Research (United States)
2019
Utilizing a standardized dataset with specific definitions to prospectively collect international data provide benchmark for complications and outcomes associated esophagectomy.Outcome reporting in oncologic surgery has suffered from the lack of system operative results particularly complications. This is case esophagectomy affecting accuracy relevance outcome assessments, clinical trial results, quality improvement projects.The Esophageal Complications Consensus Group (ECCG) involving 24...
PURPOSE Preoperative chemoradiotherapy according to the for esophageal cancer followed by surgery study (CROSS) has become a standard of care patients with locally advanced resectable or junctional cancer. We aimed assess long-term outcome this regimen. METHODS From 2004 through 2008, we randomly assigned 366 either five weekly cycles carboplatin and paclitaxel concurrent radiotherapy (41.4 Gy in 23 fractions, 5 days per week) surgery, alone. Follow-up data were collected 2018. Cox...
To test whether the newly developed comprehensive complication index (CCI) is more sensitive than traditional endpoints for detecting between-group differences in randomized controlled trials (RCTs).A major challenge RCTs choice of optimal to detect treatment effects. Mortality no longer a sufficient marker studies, and morbidity often poorly defined. The CCI, integrating all complications including their severity linear scale ranging from 0 (no complication) 100 (death), new tool, which may...
Objective: To define "best possible" outcomes in total minimally invasive transthoracic esophagectomy (ttMIE). Background: TtMIE, performed by experts patients with low comorbidity, may serve as a benchmark procedure for esophagectomy. Patients and Methods: From cohort of 1057 ttMIE, over 5-year period 13 high-volume centers esophageal surgery, we selected study group 334 (31.6%) that fulfilled criteria comorbidity (American Society Anesthesiologists score ≤2, WHO/ECOG ≤1, age ≤65 years,...
Abstract Background Quality assurance is acknowledged as a crucial factor in the assessment of oncological surgical care. The aim this study was to develop composite measure multiple outcome parameters defined ‘textbook outcome’, assess quality care for patients undergoing oesophagogastric cancer surgery. Methods Patients with cancer, operated on intent curative resection between 2011 and 2014, were identified from national database (Dutch Upper Gastrointestinal Cancer Audit). Textbook...
The aim of this study was to compare open esophagectomy (OE) with minimally invasive (MIE) in a population-based setting.Randomized controlled trials and cohort studies have shown that MIE is associated reduced pulmonary complications shorter hospital stay as compared OE.Patients who underwent transthoracic for cancer between 2011 2015 were selected from the national Dutch Upper Gastrointestinal Cancer Audit. Hybrid, transhiatal, emergency procedures excluded. Patients OE those treated by...
This nation-wide population-based study aimed to report postoperative morbidity and mortality after esophagectomy gastrectomy in the Netherlands according definitions of Esophagectomy Complications Consensus Group (ECCG).To standardize international outcome reporting esophageal surgery, ECCG developed a standardized outcomes set.For this national cohort study, all patients undergoing or for cancer between 2016 2017 were selected from Dutch Upper gastrointestinal Cancer Audit. In random...
This is a randomized, controlled trial of preoperative chemotherapy in patients undergoing surgery for oesophageal squamous cell carcinoma (OSCC). Patients were allocated to chemotherapy, consisting 2-4 cycles cisplatin and etoposide, followed by (CS group) or alone (S group). Initial results reported only abstract form 1997, demonstrated an advantage overall survival the CS group. The this have been updated discussed timeframe which study was performed. recruited 169 with OSCC, 85 assigned...
To evaluate prognostic factors and tumor staging in patients after esophagectomy for cancer.Several reports have questioned the appropriateness of sixth edition International Union Against Cancer (UICC) TNM guidelines esophageal cancer. Additional pathologic characteristics, besides 3 basic facets anatomic spread (tumor, node, metastases), might also value.All who underwent resection esophagus carcinoma between January 1995 March 2003 were extracted from a prospective database. Univariate...
The volume–outcome relationship for complex surgical procedures has been extensively studied. Most studies are based on administrative data and use in-hospital mortality as the sole outcome measure. It is still unknown if concentration of these leads to improvement clinical outcome. aim our study was audit process effect centralizing oesophageal resections cancer by using detailed data. From January 1990 until December 2004, 555 esophagectomies were performed in 11 hospitals region...
The new 7th edition of the Union for International Cancer Control-American Joint Committee on (UICC-AJCC) tumor, node, metastasis (TNM) staging system is ratification data-driven recommendations from Worldwide Esophageal Collaboration database. Generalizability remains questionable single institutions. present study serves as a validation TNM in prospective cohort patients with predominantly adenocarcinomas institution.
Abstract Background The genetic changes that drive metaplastic progression from squamous oesophageal mucosa toward intestinal metaplasia and adenocarcinoma are unclear. aberrant expression of microRNAs (miRNAs) is involved in the development cancer. This study examined whether miRNAs play a role adenocarcinoma. Methods RNA was extracted normal epithelium, gastric Barrett's oesophagus with obtained 16 individuals. Expression profiles 377 human were determined by microarray analysis selected...
For gastric cancer patients, surgical resection with en-bloc lymphadenectomy is the cornerstone of curative treatment. Open gastrectomy has long been preferred approach worldwide. However, this procedure associated considerable morbidity. Several meta-analyses have shown an advantage in short-term outcomes laparoscopic compared to open procedures, similar oncologic outcomes. it remains unclear whether results these Asian studies can be extrapolated Western population. In trial from...
It is unclear how the extent of surgical lymph node clearance influences prognosis after surgery for esophageal cancer. This nationwide, population-based cohort study included 1044 cancer patients who had undergone esophagectomy between 1987 and 2010 in Sweden, with follow-up until 2012. The independent role removal relation to survival was analyzed using Cox proportional hazards regression, providing hazard ratios (HRs) 95% confidence intervals (CIs), adjusted age, sex, comorbidity, tumor...
Purpose To compare pre-agreed health-related quality of life (HRQOL) domains in patients with esophageal or junctional cancer who received neoadjuvant chemoradiotherapy (nCRT) followed by surgery alone. Secondary aims were to examine the effect nCRT on HRQOL before and HRQOL. Patients Methods randomly assigned (carboplatin plus paclitaxel concurrent 41.4-Gy radiotherapy) was measured using European Organisation for Research Treatment Cancer Quality Life Questionnaire–Core 30 (QLQ-C30)...
Recent studies have suggested that sarcopenia is a prognostic risk indicator of postoperative complications and predicts survival in cancer patients. The aim this study to investigate whether associated with short-term outcome (morbidity mortality) long-term patients undergoing esophagectomy for after neoadjuvant chemoradiotherapy.All who underwent chemoradiotherapy followed by cancer, whom an adequate CT scan was available, were included the current study. presence defined imaging using...
At present, palliative systemic chemotherapy is the standard treatment in Netherlands for gastric cancer patients with peritoneal dissemination. In contrast to lymphatic and haematogenous dissemination, dissemination may be regarded as locoregional spread of disease. Administering cytotoxic drugs directly into cavity has an advantage over since high concentrations can delivered limited toxicity. The combination a radical gastrectomy cytoreductive surgery (CRS) hyperthermic intraperitoneal...
To evaluate changes in treatment and outcomes of esophagogastric cancer surgery after introduction the DUCA. In addition, presence risk-averse behavior was assessed.Clinical auditing is seen as an important quality improvement tool; however, its long-term efficacy remains largely unknown. critics claim that enhancements result from rather than positive effects auditing.DUCA data were used registration start (1-1-2011) until 31-12-2018. Trends patient, tumor, hospital characteristics...
<h3>Importance</h3> The optimal staging for gastric cancer remains a matter of debate. <h3>Objective</h3> To evaluate the value of<sup>18</sup>F-fludeoxyglucose–positron emission tomography with computed (FDG-PET/CT) and laparoscopy (SL) in addition to initial by means gastroscopy CT patients locally advanced cancer. <h3>Design, Setting, Participants</h3> This multicenter prospective, observational cohort study included 394 advanced, clinically curable adenocarcinoma (≥cT3 and/or N+, M0...