A5085740912- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Intraperitoneal and Appendiceal Malignancies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Ovarian cancer diagnosis and treatment
- MRI in cancer diagnosis
- Appendicitis Diagnosis and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Endometriosis Research and Treatment
- Gastric Cancer Management and Outcomes
- Advanced X-ray and CT Imaging
- Anorectal Disease Treatments and Outcomes
- Cancer Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Cancer Genomics and Diagnostics
- Medical Imaging Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Radiology practices and education
- Global Cancer Incidence and Screening
- Endometrial and Cervical Cancer Treatments
- Gallbladder and Bile Duct Disorders
- Cardiac, Anesthesia and Surgical Outcomes
Oncode Institute
2016-2025
The Netherlands Cancer Institute
2016-2025
Maastricht University
2008-2025
Maastricht University Medical Centre
2007-2024
Dutch Cancer Society
2020-2022
Novartis (Switzerland)
2021
Merck Serono (Switzerland)
2021
Roche (Switzerland)
2021
Sanofi (France)
2021
Seagen (Canada)
2021
The aim of this study was to evaluate the efficacy and tolerability topiramate for prevention chronic migraine in a randomized, double-blind, placebo-controlled trial. Chronic is common form disabling headache presenting subspecialty practice. Preventive treatments are essential management, although there few or no controlled empirical trial data on their use patient population. Topiramate approved prophylaxis adults. Patients (18-65 years) who experienced (defined as > =15 monthly days) =3...
Abstract Multiparametric Magnetic Resonance Imaging (MRI) can provide detailed information of the physical characteristics rectum tumours. Several investigations suggest that volumetric analyses on anatomical and functional MRI contain clinically valuable information. However, manual delineation tumours is a time consuming procedure, as it requires high level expertise. Here, we evaluate deep learning methods for automatic localization segmentation rectal cancers multiparametric MR imaging....
The management of incidentally detected gallbladder polyps on radiological examinations is contentious. incidental finding a polyp can therefore be problematic for the radiologist and clinician who referred patient examination. To address this joint guideline was created by European Society Gastrointestinal Abdominal Radiology (ESGAR), Association Endoscopic Surgery other Interventional Techniques (EAES), International Digestive – Federation (EFISDS) Endoscopy (ESGE). A targeted literature...
To prospectively determine diagnostic performance of predictive criteria for nodal staging with ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance (MR) imaging in primary rectal cancer patients, histopathologic findings as reference standard.Institutional review board approval and informed consent were obtained. Twenty-eight patients (18 men, 10 women; mean age, 68 years) underwent USPIO-enhanced MR. Two observers different experience evaluated each node on...
To retrospectively assess accuracy of magnetic resonance (MR) imaging after radiation therapy with concomitant chemotherapy for downsizing the primary lesion to ypT0-2 tumor confined rectal wall in locally advanced cancer, histopathologic findings as reference standard, and evaluate additional value volumetric analysis.The institutional review board approved study waived informed consent. Sixty-seven patients met criteria study. T2-weighted MR images obtained before were assessed stage by...
To prospectively assess the accuracy of gadofosveset-enhanced magnetic resonance imaging (MRI) for nodal staging and restaging in rectal cancer.Accurate preoperative assessment disease cancer impacts treatment management. Staging with modern techniques (computed tomography, MRI endorectal ultrasound) is insufficiently accurate clinical decision making. This study aims to using a novel lymph node contrast, gadofosveset, per comparison histology as reference standard.Sixty-eight patients...
Abstract Background Upfront cytoreductive surgery with HIPEC (CRS-HIPEC) is the standard treatment for isolated resectable colorectal peritoneal metastases (PM) in Netherlands. This study investigates whether addition of perioperative systemic therapy to CRS-HIPEC improves oncological outcomes. Methods open-label, parallel-group, phase II-III, randomised, superiority performed nine Dutch tertiary referral centres. Eligible patients are adults who have a good performance status,...
At present, palliative systemic chemotherapy is the standard treatment in Netherlands for gastric cancer patients with peritoneal dissemination. In contrast to lymphatic and haematogenous dissemination, dissemination may be regarded as locoregional spread of disease. Administering cytotoxic drugs directly into cavity has an advantage over since high concentrations can delivered limited toxicity. The combination a radical gastrectomy cytoreductive surgery (CRS) hyperthermic intraperitoneal...
BACKGROUND: Patients with a locally advanced rectal carcinoma benefit from preoperative chemoradiotherapy. MRI is considered the first choice imaging modality after chemoradiation, although its reliability for restaging debatable. OBJECTIVE: The purpose of this study was to determine accuracy in cancer chemoradiation. DESIGN: This retrospective study. SETTINGS: conducted Dutch high-volume center. PATIENTS: A consecutive cohort 48 patients treated curative intent identified. MAIN OUTCOME...
1. Primary investigation of polypoid lesions the gallbladder should be with abdominal ultrasound. Routine use other imaging modalities is not recommended presently, but further research needed. In centres appropriate expertise and resources, alternative (such as contrast-enhanced endoscopic ultrasound) may useful to aid decision-making in difficult cases. Strong recommendation, low-moderate quality evidence. 2. Cholecystectomy patients measuring 10 mm or more, providing patient fit for,...
To identify the main problem areas in applicability of current TNM staging system (8th ed.) for radiological and reporting rectal cancer provide practice recommendations on how to handle them.A global case-based online survey was conducted including 41 image-based cases focusing various items included system. Cases reaching < 80% agreement among respondents were identified as discussed an international expert panel, 5 radiologists, 6 colorectal surgeons, 4 radiation oncologists, 3...
To prospectively determine diagnostic performance of predictive criteria for nodal restaging after radiation therapy with concomitant chemotherapy by using ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance (MR) imaging in patients rectal cancer.After institutional review board approval and informed consent were obtained, 39 (24 men, 15 women; mean age, 64 years) cancer underwent USPIO-enhanced two-dimensional (2D) T2-weighted fast spin-echo, three-dimensional (3D)...
BACKGROUND: Colon cancer is currently staged with CT. However, MRI superior in the detection of colorectal liver metastasis, and standard local staging rectal cancer. Optimal (local) colon could become crucial selecting patients for neoadjuvant treatment near future (Fluoropyrimidine Oxaliplatin Targeted Receptor Preoperative Therapy trial). OBJECTIVE: The purpose this study was to evaluate diagnostic performance DESIGN: This a retrospective study. SETTINGS: conducted at Maastricht...
Diffusion-weighted imaging is increasingly used in rectal cancer MRI to assess response after chemoradiotherapy. Certain pitfalls (eg, artefacts) may hamper diffusion-MRI assessment, leading suboptimal diagnostic performance. Combining diffusion-weighted with the underlying morphology on standard (T2-weighted) help overcome these pitfalls.The purpose of this study was evaluate performance a pattern-based approach combining tumor T2-weighted distinct signal patterns chemoradiotherapy...
Abstract Background Patients with limited peritoneal metastases from colorectal cancer may be candidates for an aggressive surgical approach including cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS–HIPEC). Selection is based on inspection during laparoscopy or laparotomy. The aim of this study was to investigate whether diffusion-weighted MRI (DW-MRI) can used select patients CRS–HIPEC. Methods This a prospective at tertiary referral centre. confirmed suspected...
<h3>Importance</h3> To date, no randomized clinical trials have investigated perioperative systemic therapy relative to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) alone for resectable colorectal peritoneal metastases (CPM). <h3>Objective</h3> assess the feasibility safety of in patients with CPM response neoadjuvant treatment. <h3>Design, Setting, Participants</h3> An open-label, parallel-group phase 2 trial all 9 Dutch tertiary centers surgical treatment...