A5000607523- Microbial Inactivation Methods
- Immunotherapy and Immune Responses
- Hepatocellular Carcinoma Treatment and Prognosis
- Cutaneous Melanoma Detection and Management
- CAR-T cell therapy research
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Breast Implant and Reconstruction
- T-cell and B-cell Immunology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cell Adhesion Molecules Research
- Liver Disease Diagnosis and Treatment
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Breast Lesions and Carcinomas
- Monoclonal and Polyclonal Antibodies Research
- Plant tissue culture and regeneration
- Neuroendocrine Tumor Research Advances
- Magnetic and Electromagnetic Effects
- Muscle and Compartmental Disorders
- Cancer Cells and Metastasis
- MRI in cancer diagnosis
- Skin Protection and Aging
- Atherosclerosis and Cardiovascular Diseases
Medisch Centrum Leeuwarden
2023-2024
Amsterdam University Medical Centers
2019-2024
Vrije Universiteit Amsterdam
2009-2024
Cancer Center Amsterdam
2010-2021
Virginia Tech
2020
University of Ljubljana
2020
Wake Forest University
2020
Amsterdam UMC Location Vrije Universiteit Amsterdam
2004-2018
Ziekenhuis Gelderse Vallei
2016
Rotterdam University of Applied Sciences
1998
Purpose: Local tumor ablation through irreversible electroporation (IRE) may offer a novel therapeutic option for locally advanced pancreatic cancer (LAPC). It also serve as means of in vivo vaccination. To obtain evidence the induction systemic antitumor immunity following local IRE-mediated ablation, we performed an explorative immune monitoring study. Methods: In ten patients enrolled clinical trial exploring safety, feasibility, and efficacy percutaneous image-guided IRE LAPC, determined...
To evaluate whether infliction of peritoneal trauma would promote tumor cell adherence to damaged surfaces; investigate damage could growth extraperitoneal tumors; and the amount correlated with degree local distant growth.After potentially curative resection colorectal carcinoma, most common site for recurrence is locoregional. We previously demonstrated that surgical induces a cascade events leading adhesion formation. The same mechanisms may be responsible improved facilitation in early...
Background Irreversible electroporation (IRE), an ablative technique that uses high-voltage electrical pulses, has shown promise for eradicating tumors near critical structures, including blood vessels and bile ducts. Purpose To investigate the efficacy safety of IRE colorectal liver metastases (CRLMs) unsuitable resection or thermal ablation because proximity to structures further systemically administered treatments. Materials Methods Between June 2014 November 2018, participants with...
<h3>Background</h3> Immune regulated pathways influence both breast cancer (BrC) development and response to (neo)adjuvant chemotherapy. The sentinel lymph node (SLN), as the first metastatic site, is also site where BrC-induced suppression of immune effector subsets occurs. Since intricate knowledge phenotypic functional status these lacking, we set out map landscape BrC SLN. <h3>Methods</h3> Viable LN cells from SLN (<i>n</i> = 58) were used for detailed flowcytometry-assisted mapping in a...
Melanoma exerts immune-suppressive effects to facilitate tumor progression and metastatic spread. We studied these on dendritic cell (DC) T-cell subsets in 36 melanoma sentinel lymph node (SLN) from 28 stage I-III patients determined their clinical significance. Four conventional DC subsets, plasmacytoid DCs, CD4+, CD8+, regulatory T cells (Tregs), were analyzed by flow cytometry. correlated data parameters effect local distant recurrence, with a median follow-up of 75 months. In I II...
The aim of this study was to assess safety, efficacy and survival outcomes repeat thermal ablation as compared partial hepatectomy in patients with recurrent colorectal liver metastases (CRLM). This Amsterdam Colorectal Liver Met Registry (AmCORE) based two cohorts, versus hepatectomy, analyzed 136 (100 ablation, 36 hepatectomy) 224 tumors (170 54 CRLM from May 2002 December 2020. primary secondary endpoints were overall (OS), distant progression-free (DPFS) local tumor (LTPFS), estimated...
Local tumor progression (LTP) is a serious complication after local ablation of malignant liver tumors, negatively influencing patient survival. LTP may be the result incomplete treated tumor. In this study, we determined whether viable cells attached to needle applicator was associated with and disease-free survival.In prospective tissue collected 96 consecutive patients who underwent ablations for 130 malignancies. Cells applicators were analyzed viability using...
Introduction Cosmetic results and quality of life (QoL) are increasingly important in the treatment breast cancer. This study was designed to determine relationship between QoL both subjectively objectively measured cosmetic outcomes breast‐conserving therapy (BCT), its course over time. Methods A total 128 cancer patients who underwent BCT as part a prospective randomized controlled trial were included. using EORTC QLQ‐C30 QLQ‐BR23 at baseline, 3, 6, 12, 36 months. outcome determined by...
Background and Objectives To identify breast‐specific factors the role of tumor, treatment, patient‐related items in influencing patient opinion on cosmesis satisfaction after breast‐conserving therapy (BCT). Methods Data from randomized COBALT study was used. At 3, 12, 36 months, 128 patients with T1‐T2 breast cancer completed a questionnaire overall cosmetic outcome satisfaction, using 4‐point Likert scale. Results There strong positive correlation between factors, outcome,and at all...
Background: In the literature, promising results have been obtained with radiofrequency ablation (RFA) of primary liver malignancies (e.g. hepatocellular carcinoma, HCC) and secondary metastases colorectal tumors). our center, positron emission tomography FDG (FDG-PET) computed (CT) were used for follow-up. Patient outcome was compared that in PET CT analyzed regarding positive negative predictive values early detection tumor recurrence. Methods: The data patients who treated RFA or tumors...
<i>Aim:</i> Local recurrence and needle track seeding are serious complications after local ablation for liver malignancies potentially affect long-term survival. The aim of this study was to assess the incidence viable tissue adherent applicators gain insight into possible mechanisms seeding. <i>Methods:</i> A total 40 consecutive patients underwent 59 ablations. Cells attached were analysed morphology (HE, PAP Giemsa staining) viability (G6PD staining)....
In patients that require treatment for hepatic giant cavernous hemangiomas (GCH), radiofrequency ablation (RFA) has been suggested to represent a safe and effective alternative invasive surgery. recent report of bipolar RFA, using two expandable needle electrodes, was uneventfully performed in with large GCH (>10 cm). The objective this is present cases which RFA symptomatic complicated by acute kidney injury. 2015 we treated very (15.7 25.0 cm) during open laparotomy. both the urine showed...
Purpose: Thermal ablation is widely recognized as the standard of care for small-size unresectable colorectal liver metastases (CRLM). For larger CRLM safety, local control and overall efficacy are not well established insufficiently validated. The purpose this comparative series was to analyze outcomes intermediate-size versus CRLM. Material methods: Patients treated with thermal between December 2000 November 2021 were included. primary endpoints complication rate (LC). Secondary included...
Irreversible electroporation (IRE) is a novel image-guided ablation technique that rapidly gaining popularity in the treatment of malignant tumors located near large vessels or bile ducts. The presence metal objects zone, such as Wallstents, generally considered contraindication for IRE, because tissue heating due to power conduction may lead thermal complications. This report describes 66-year-old female with Bismuth–Corlette stage IV unresectable cholangiocarcinoma metallic Wallstent...