A5064209010- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Microbial Inactivation Methods
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Plant tissue culture and regeneration
- Plasma Applications and Diagnostics
- Advanced Radiotherapy Techniques
- Microfluidic and Bio-sensing Technologies
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Toxin Mechanisms and Immunotoxins
- Cancer, Stress, Anesthesia, and Immune Response
- Magnetic and Electromagnetic Effects
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Immunotherapy and Immune Responses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Delphi Technique in Research
- Pulsed Power Technology Applications
OLVG
2023-2025
Amsterdam University Medical Centers
2018-2025
Cancer Center Amsterdam
2020-2024
Vrije Universiteit Amsterdam
2019-2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2018-2023
Terumo (Germany)
2023
Geneeskundige en Gezondheidsdienst
2023
University of Amsterdam
2019-2021
University of Ljubljana
2020
Virginia Tech
2020
Radiofrequency ablation (RFA) and microwave (MWA) are widely accepted techniques to eliminate small unresectable colorectal liver metastases (CRLM). Although previous studies labelled thermal inferior surgical resection, the apparent selection bias when comparing patients with disease candidates, superior safety profile, competitive overall survival results for more recent reports mandate setup of a randomized controlled trial. The objective COLLISION trial is prove non-inferiority compared...
There is currently no consensus regarding preferred clinical outcome measures following image-guided tumor ablation or clear definitions of oncologic end points. This document proposes standardized for a broad range with recommendations on how to uniformly document, analyze, and report outcomes. The initiative was coordinated by the Society Interventional Oncology in collaboration Definition Assessment Time-to-Event End Points Cancer Trials, DATECAN, group. According predefined criteria,...
LBA3501 Background: The standard of care for local treatment patients (pts) with colorectal liver metastases (CRLM) is surgical resection. However, growing evidence suggests thermal ablation to be associated a superior safety profile, lower costs, and shorter hospital stay, while rivaling resection in terms control overall survival (OS). This study aimed explore the potential non-inferiority compared pts small-size (≤3cm) resectable CRLM. Methods: In this multicenter, phase 3 Dutch...
Background Patients with locally advanced pancreatic cancer have a dismal prognosis, median overall survival (OS) of 12–14 months systemic therapies. Irreversible electroporation (IRE), nonthermal ablative technique, may prolong patients cancer. Purpose To investigate the safety and efficacy percutaneous IRE for recurring in prospective phase II trial. Materials Methods Between December 2012 September 2017, participants or postresection local recurrence were prospectively treated CT-guided...
The guidelines for metastatic colorectal cancer crudely state that the best local treatment should be selected from a ‘toolbox’ of techniques according to patient- and treatment-related factors. We created an interdisciplinary, consensus-based algorithm with specific resectability ablatability criteria liver metastases (CRLM). To pursue consensus, members multidisciplinary COLLISION COLDFIRE trial expert panel employed RAND appropriateness method (RAM). Statements regarding patient, disease,...
Background Irreversible electroporation (IRE), an ablative technique that uses high-voltage electrical pulses, has shown promise for eradicating tumors near critical structures, including blood vessels and bile ducts. Purpose To investigate the efficacy safety of IRE colorectal liver metastases (CRLMs) unsuitable resection or thermal ablation because proximity to structures further systemically administered treatments. Materials Methods Between June 2014 November 2018, participants with...
To analyze long-term oncological outcomes of open and percutaneous thermal ablation in the treatment patients with colorectal liver metastases (CRLM).This assessment from a prospective, longitudinal tumor registry included 329 who underwent 541 procedures for 1350 CRLM January 2010 to February 2021. Three cohorts were formed: 2010-2013 (129 [53 percutaneous]), 2014-2017 (206 [121 percutaneous]) 2018-2021 [135 percutaneous]). Local progression-free survival (LTPFS) overall (OS) data estimated...
The aim of this study was to assess safety, efficacy and survival outcomes repeat thermal ablation as compared partial hepatectomy in patients with recurrent colorectal liver metastases (CRLM). This Amsterdam Colorectal Liver Met Registry (AmCORE) based two cohorts, versus hepatectomy, analyzed 136 (100 ablation, 36 hepatectomy) 224 tumors (170 54 CRLM from May 2002 December 2020. primary secondary endpoints were overall (OS), distant progression-free (DPFS) local tumor (LTPFS), estimated...
The aim of this study was to assess primary tumor sidedness colorectal cancer (CRC), rat sarcoma viral oncogene homolog (RAS) and v-raf murine B (BRAF) mutations microsatellite instability (MSI) status as prognostic factors predicting complications, survival outcomes, local progression (LTP) following surgery thermal ablation in patients with liver metastases (CRLM). This Amsterdam Colorectal Liver Met Registry (AmCORE) based included 520 patients, 774 procedures, 2101 tumors undergoing...
Background Irreversible electroporation (IRE) and stereotactic ablative body radiotherapy (SABR) are cytoreductive therapies for locally advanced pancreatic cancer (LAPC). Both may signify immunogenic cell death. We aimed to compare systemic immune responses between the treatments. Methods As part of randomized phase II CROSSFIRE trial ( NCT02791503 ), comparing oncological efficacy IRE SABR in patients with LAPC, pre- post-treatment (2 weeks 3 months) peripheral blood samples were...
Irreversible electroporation (IRE) is a novel image-guided tumor ablation technique with the ability to generate window for establishment of systemic antitumor immunity. IRE transiently alters tumor’s immunosuppressive microenvironment while simultaneously generating antigen release, thereby instigating an adaptive immune response. Combining immunotherapeutic drugs, i.e., electroimmunotherapy, has synergistic potential and might induce durable The primary objective this study assess safety...
With the rapidly evolving field of image-guided tumor ablation, there is an increasing demand and need for tools to optimize treatment success. Known factors affecting success (non-)thermal liver ablation procedures are ability surrounding critical structure visualization, applicator targeting, zone confirmation. A recent study showed superior local progression-free survival control outcomes when using transcatheter computed tomography hepatic angiography (CTHA) guidance in percutaneous...
In percutaneous ablation procedures, periprocedural pain, unrest and respiratory concerns can be detrimental to achieve a safe efficacious impair treatment outcome. This study aimed compare the association between anesthetic technique local disease control in patients undergoing microwave (MWA) of colorectal liver metastases (CRLM) hepatocellular carcinoma (HCC). IRB-exempted single-center comparative, retrospective analysis three cohorts analyzed 90 treated for hepatic malignancies from...
Purpose: Thermal ablation is widely recognized as the standard of care for small-size unresectable colorectal liver metastases (CRLM). For larger CRLM safety, local control and overall efficacy are not well established insufficiently validated. The purpose this comparative series was to analyze outcomes intermediate-size versus CRLM. Material methods: Patients treated with thermal between December 2000 November 2021 were included. primary endpoints complication rate (LC). Secondary included...