A5024500835- Microbial Inactivation Methods
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Microfluidic and Bio-sensing Technologies
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Magnetic and Electromagnetic Effects
- Plasma Applications and Diagnostics
- MRI in cancer diagnosis
- Toxin Mechanisms and Immunotoxins
- Plant tissue culture and regeneration
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Ultrasound and Cavitation Phenomena
- Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Vascular Malformations and Hemangiomas
- Neuroendocrine Tumor Research Advances
Noordwest Ziekenhuisgroep
2023-2025
Amsterdam University Medical Centers
2018-2024
Northwest Hospital
2024
Cancer Center Amsterdam
2019-2024
Vrije Universiteit Amsterdam
2018-2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2012-2023
Amsterdam UMC Location University of Amsterdam
2015-2021
University Medical Center Utrecht
2021
München Klinik Bogenhausen
2021
University of Amsterdam
2019-2020
Radiofrequency ablation (RFA) and microwave (MWA) are widely accepted techniques to eliminate small unresectable colorectal liver metastases (CRLM). Although previous studies labelled thermal inferior surgical resection, the apparent selection bias when comparing patients with disease candidates, superior safety profile, competitive overall survival results for more recent reports mandate setup of a randomized controlled trial. The objective COLLISION trial is prove non-inferiority compared...
There is currently no consensus regarding preferred clinical outcome measures following image-guided tumor ablation or clear definitions of oncologic end points. This document proposes standardized for a broad range with recommendations on how to uniformly document, analyze, and report outcomes. The initiative was coordinated by the Society Interventional Oncology in collaboration Definition Assessment Time-to-Event End Points Cancer Trials, DATECAN, group. According predefined criteria,...
Purpose To (a) investigate the safety of percutaneous irreversible electroporation (IRE) for locally advanced pancreatic cancer and (b) evaluate quality life (QOL), pain perception, efficacy in terms time to local progression, event-free survival, overall survival (OS). Materials Methods The study was approved by review board (NL42888.029.13). All patients provided written informed consent participation, ablation procedure, data usage. Between January 2014 June 2015, 25 with histologically...
Background Patients with locally advanced pancreatic cancer have a dismal prognosis, median overall survival (OS) of 12–14 months systemic therapies. Irreversible electroporation (IRE), nonthermal ablative technique, may prolong patients cancer. Purpose To investigate the safety and efficacy percutaneous IRE for recurring in prospective phase II trial. Materials Methods Between December 2012 September 2017, participants or postresection local recurrence were prospectively treated CT-guided...
Purpose: Local tumor ablation through irreversible electroporation (IRE) may offer a novel therapeutic option for locally advanced pancreatic cancer (LAPC). It also serve as means of in vivo vaccination. To obtain evidence the induction systemic antitumor immunity following local IRE-mediated ablation, we performed an explorative immune monitoring study. Methods: In ten patients enrolled clinical trial exploring safety, feasibility, and efficacy percutaneous image-guided IRE LAPC, determined...
The guidelines for metastatic colorectal cancer crudely state that the best local treatment should be selected from a ‘toolbox’ of techniques according to patient- and treatment-related factors. We created an interdisciplinary, consensus-based algorithm with specific resectability ablatability criteria liver metastases (CRLM). To pursue consensus, members multidisciplinary COLLISION COLDFIRE trial expert panel employed RAND appropriateness method (RAM). Statements regarding patient, disease,...
To retrospectively analyse the safety and efficacy of radiofrequency ablation (RFA) versus microwave (MWA) in treatment unresectable colorectal liver metastases (CRLM) proximity to large vessels and/or major bile ducts. A database search was performed include patients with histologically proven 18F–FDG–PET avid CRLM who were treated RFA or MWA between January 2001 September 2014 a single centre. All lesions that considered have peribiliary perivascular location included. Univariate logistic...
Background Irreversible electroporation (IRE), an ablative technique that uses high-voltage electrical pulses, has shown promise for eradicating tumors near critical structures, including blood vessels and bile ducts. Purpose To investigate the efficacy safety of IRE colorectal liver metastases (CRLMs) unsuitable resection or thermal ablation because proximity to structures further systemically administered treatments. Materials Methods Between June 2014 November 2018, participants with...
To analyze long-term oncological outcomes of open and percutaneous thermal ablation in the treatment patients with colorectal liver metastases (CRLM).This assessment from a prospective, longitudinal tumor registry included 329 who underwent 541 procedures for 1350 CRLM January 2010 to February 2021. Three cohorts were formed: 2010-2013 (129 [53 percutaneous]), 2014-2017 (206 [121 percutaneous]) 2018-2021 [135 percutaneous]). Local progression-free survival (LTPFS) overall (OS) data estimated...
Irreversible electroporation (IRE) uses short duration, high-voltage electrical pulses to induce cell death via nanoscale defects resulting from altered transmembrane potential. The technique is gaining interest for ablations in unresectable pancreatic and hepatobiliary cancer. Metal stents are often used palliative biliary drainage these patients, but currently seen as an absolute contraindication IRE due the perceived risk of direct heating metal its surroundings. This study investigates...
Irreversible electroporation (IRE) is a novel image-guided tumor ablation technique that has shown promise for the of lesions in proximity to vital structures such as blood vessels and bile ducts. The primary aim COLDFIRE-2 trial investigate efficacy IRE unresectable, centrally located colorectal liver metastases (CRLM). Secondary outcomes are safety, technical success, accuracy contrast-enhanced (ce)CT (18)F-FDG PET-CT detection local progression (LTP).In this single-arm, multicenter phase...