Joris I. Erdmann
A5048525603- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Genetic and Kidney Cyst Diseases
- Pancreatitis Pathology and Treatment
- Liver physiology and pathology
- Cancer Diagnosis and Treatment
- Viral-associated cancers and disorders
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Nutrition and Health in Aging
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Liver Diseases and Immunity
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
Cancer Center Amsterdam
2022-2025
Amsterdam University Medical Centers
2019-2025
University of Amsterdam
2019-2025
Vrije Universiteit Amsterdam
2022-2025
Amsterdam UMC Location University of Amsterdam
2023
Cambridge University Hospitals NHS Foundation Trust
2023
University Medical Center Groningen
2016-2021
University of Groningen
2018-2021
Leiden University Medical Center
2019-2021
Brain Tumour Charity
2020
Transplantation of livers obtained from donors after circulatory death is associated with an increased risk nonanastomotic biliary strictures. Hypothermic oxygenated machine perfusion may reduce the incidence complications, but data prospective, controlled studies are limited.In this multicenter, trial, we randomly assigned patients who were undergoing transplantation a liver donor to receive that either hypothermic (machine-perfusion group) or conventional static cold storage alone (control...
The aim of this study was to develop an alternative fistula risk score (a-FRS) for postoperative pancreatic (POPF) after pancreatoduodenectomy, without blood loss as a predictor.Blood loss, one the predictors original-FRS, not significant factor during 2 recent external validations.The a-FRS developed in databases: Dutch Pancreatic Cancer Audit (18 centers) and University Hospital Southampton NHS. Primary outcome grade B/C POPF according 2005 International Study Group on Surgery (ISGPS)...
In Brief Background: The role of adjuvant chemoradiation in pancreatic cancer remains unclear. This report presents the long-term follow-up results EORTC trial 40891, which assessed resectable cancer. Methods: Two hundred eighteen patients were randomized after resection primary tumor. Eligible had T1–2 N0-N1a M0 or T1–3 periampullary cancers, all histologic proven. Patients treatment group (n = 110) underwent postoperative (40 Gy plus 5-FU). control 108) no further treatment. Findings:...
Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer, whose incidence related mortality increasing. This study investigates the clinical course of CCA subtypes (intrahepatic [iCCA], perihilar [pCCA], distal [dCCA]) in pan-European cohort.The ENSCCA Registry multicenter observational study. Patients were included if they had histologically proven diagnosis between 2010-2019. Demographic, histomorphological, biochemical, studies performed.Overall, 2,234 patients enrolled...
Objective: The aim of this study was to define robust benchmark values for the surgical treatment perihilar cholangiocarcinomas (PHC) enable unbiased comparisons. Background: Despite ongoing efforts, postoperative mortality and morbidity remains high after complex liver surgery PHC. Benchmark data best achievable results in PHC are however still lacking. Methods: This analyzed consecutive patients undergoing major 24 high-volume centers 3 continents over recent 5-year period (2014–2018) with...
Abstract Background Posthepatectomy liver failure (PHLF) contributes significantly to morbidity and mortality after surgery. Standardized assessment of preoperative function is crucial identify patients at risk. These European consensus guidelines provide guidance for patient assessment. Methods A modified Delphi approach was used achieve consensus. The expert panel consisted hepatobiliary surgeons, radiologists, nuclear medicine specialists, hepatologists. guideline process supervised by a...
Pancreatic cancer is the fourth largest cause of death in United States and Europe with over 100,000 deaths per year alone. The overall 5-year survival ranges from 2–7 % has hardly improved last two decades. Approximately 15 all patients have resectable disease at diagnosis, those, only a subgroup tumour surgical exploration. Data cohort studies suggested that outcome can be by preoperative radiochemotherapy, but data well-designed randomized are lacking. Our PREOPANC phase III trial aims to...
The guidelines for metastatic colorectal cancer crudely state that the best local treatment should be selected from a ‘toolbox’ of techniques according to patient- and treatment-related factors. We created an interdisciplinary, consensus-based algorithm with specific resectability ablatability criteria liver metastases (CRLM). To pursue consensus, members multidisciplinary COLLISION COLDFIRE trial expert panel employed RAND appropriateness method (RAM). Statements regarding patient, disease,...
Background & AimsTIGIT is a co-inhibitory receptor, and its suitability as target for cancer immunotherapy in HCC unknown. PD1 blockade clinically effective about 20% of advanced patients. Here we aim to determine whether co-blockade TIGIT/PD1 has added value restore functionality tumor-infiltrating T cells (TILs).MethodsMononuclear leukocytes were isolated from tumors, paired tumor-free liver tissues (TFL) peripheral blood patients, used flow cytometric phenotyping functional assays....
Abstract The use of cytokines for immunotherapy shows clinical efficacy but is frequently accompanied by severe adverse events caused excessive and systemic immune activation. Here, we set out to address these challenges engineering a fusion protein single, potency-reduced, IL15 mutein PD1-specific antibody (anti-PD1-IL15m). This immunocytokine was designed deliver PD1-mediated, avidity-driven IL2/15 receptor stimulation PD1+ tumor-infiltrating lymphocytes (TIL) while minimally affecting...
Abstract Background The risk of death after surgery for perihilar cholangiocarcinoma is high; nearly one in every five patients dies within 90 days surgery. When the oncological benefit limited, a high-risk resection may not be justified. This retrospective cohort study aimed to create two preoperative prognostic models predict 90-day mortality and overall survival (OS) major liver cholangiocarcinoma. Methods Separate were built with factors known before using multivariable regression...
Abstract Background A right- or left-sided liver resection can be considered in about half of patients with perihilar cholangiocarcinoma (pCCA), depending on tumor location and vascular involvement. This study compared postoperative mortality long-term survival versus resections for pCCA. Methods Patients who underwent major pCCA at 25 Western centers were stratified according to the type hepatectomy—left, extended left, right, right. The primary outcomes 90-day overall (OS). Results Between...
Beyond demographic and immune factors, metabolic considerations, particularly metformin's recognized impact in oncology, warrant exploration treating pancreatic cancer. This study aimed to investigate the influence of metformin on patient survival its potential correlation with distinct profiles ductal adenocarcinoma (PDAC) tumors.
Perihilar cholangiocarcinoma (pCCA) is a rare tumour that requires complex multidisciplinary management. All known data are almost exclusively derived from expert centres. This study aimed to analyse the outcomes of patients with pCCA in nationwide cohort.Data on all diagnosed Netherlands between 2010 and 2018 were obtained Cancer Registry. Data included type hospital diagnosis received treatment. Outcomes treatment overall survival.A total 2031 median survival for cohort was 5.2 (95% CI...
While resection remains the only curative option for perihilar cholangiocarcinoma, it is well known that such surgery associated with a high risk of morbidity and mortality. Nevertheless, beyond facing life-threatening complications, patients may also develop early disease recurrence, defining "futile" outcome in cholangiocarcinoma surgery. The aim this study to predict high-risk category (futile group) where surgical benefits are reversed alternative treatments be considered.
BackgroundCholangitis is a well-known complication after hepaticojejunostomy (HJ), which mainly caused by stenotic anastomosis. However, the rate of cholangitis in patients with non-stenotic (i.e. patent) HJ unknown. We aimed to evaluate incidence and risk factors recurrent HJ.MethodsThis single-center retrospective cohort study included all consecutive who had undergone hepatobiliary or pancreatic (HPB) surgery requiring (2015–2022). Primary outcome was cholangitis, for were identified...
Abstract Background Resection of perihilar cholangiocarcinoma (pCCA) is a complex procedure with high risk postoperative mortality and early disease recurrence. The objective this study was to compare patient characteristics overall survival (OS) between pCCA patients who underwent an R1 resection localized received palliative systemic chemotherapy. Methods Patients diagnosis 1997–2021 were identified from the European Network for Study Cholangiocarcinoma (ENS-CCA) registry. compared (i.e.,...
We evaluated the role of type I interferons (IFNs) and IFN receptors in regulation cell growth 3 human pancreatic adenocarcinoma lines (BxPC-3, MiaPaCa-2, Panc-1).Chemotherapy radiotherapy have a marginal management adenocarcinoma. The addition IFN-alpha showed promising results early clinical trials.Cell proliferation apoptosis were by DNA measurement fragmentation, respectively. Type receptor (IFNAR-1 IFNAR-2 subunits) was determined quantitative RT-PCR immunocytochemistry. Cell cycle...
Recurrences are reported in 70% of all patients after resection colorectal liver metastases (CRLM), which half confined to the liver. Adjuvant hepatic arterial infusion pump (HAIP) chemotherapy aims reduce risk intrahepatic recurrence. A large retrospective propensity score analysis demonstrated that HAIP is particularly effective with low-risk oncological features. The aim this randomized controlled trial (RCT) --the PUMP trial-- investigate efficacy adjuvant resectable CRLM. This an open...
Although Bismuth-Corlette (BC) type 4 perihilar cholangiocarcinoma (pCCA) is no longer considered a contraindication for curative surgery, few data are available from Western series to indicate the outcomes these patients. This study aimed compare short- and long-term patients with BC versus types 2 3 pCCA undergoing surgical resection using multi-institutional international database.Uni- multivariable analyses of surgery at 20 centers pCCA.Among 1138 included in study, 826 (73%) had or...