A5082877479- Microbial Inactivation Methods
- Plasma Applications and Diagnostics
- Plant tissue culture and regeneration
- Hepatocellular Carcinoma Treatment and Prognosis
- Microfluidic and Bio-sensing Technologies
- Magnetic and Electromagnetic Effects
- Toxin Mechanisms and Immunotoxins
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- MRI in cancer diagnosis
- Dermatologic Treatments and Research
- Pulsed Power Technology Applications
- CAR-T cell therapy research
- Cancer, Stress, Anesthesia, and Immune Response
- Digestive system and related health
- Innovative Microfluidic and Catalytic Techniques Innovation
- Neuroscience and Neural Engineering
- Medical Imaging and Pathology Studies
- Transgenic Plants and Applications
- Polyamine Metabolism and Applications
- Clinical Nutrition and Gastroenterology
- Ultrasound and Hyperthermia Applications
- Central Venous Catheters and Hemodialysis
- Nutrition and Health in Aging
- Pediatric Urology and Nephrology Studies
Amsterdam University Medical Centers
2018-2025
Cancer Center Amsterdam
2019-2024
Vrije Universiteit Amsterdam
2018-2021
University of Amsterdam
2019-2020
Memorial Sloan Kettering Cancer Center
2017-2020
Amsterdam UMC Location Vrije Universiteit Amsterdam
2015-2019
University Medical Center
2018
University Hospital and Clinics
2018
Amsterdam UMC Location University of Amsterdam
2017
Radiofrequency ablation (RFA) and microwave (MWA) are widely accepted techniques to eliminate small unresectable colorectal liver metastases (CRLM). Although previous studies labelled thermal inferior surgical resection, the apparent selection bias when comparing patients with disease candidates, superior safety profile, competitive overall survival results for more recent reports mandate setup of a randomized controlled trial. The objective COLLISION trial is prove non-inferiority compared...
Purpose To (a) investigate the safety of percutaneous irreversible electroporation (IRE) for locally advanced pancreatic cancer and (b) evaluate quality life (QOL), pain perception, efficacy in terms time to local progression, event-free survival, overall survival (OS). Materials Methods The study was approved by review board (NL42888.029.13). All patients provided written informed consent participation, ablation procedure, data usage. Between January 2014 June 2015, 25 with histologically...
Background Patients with locally advanced pancreatic cancer have a dismal prognosis, median overall survival (OS) of 12–14 months systemic therapies. Irreversible electroporation (IRE), nonthermal ablative technique, may prolong patients cancer. Purpose To investigate the safety and efficacy percutaneous IRE for recurring in prospective phase II trial. Materials Methods Between December 2012 September 2017, participants or postresection local recurrence were prospectively treated CT-guided...
Purpose: Local tumor ablation through irreversible electroporation (IRE) may offer a novel therapeutic option for locally advanced pancreatic cancer (LAPC). It also serve as means of in vivo vaccination. To obtain evidence the induction systemic antitumor immunity following local IRE-mediated ablation, we performed an explorative immune monitoring study. Methods: In ten patients enrolled clinical trial exploring safety, feasibility, and efficacy percutaneous image-guided IRE LAPC, determined...
To retrospectively analyse the safety and efficacy of radiofrequency ablation (RFA) versus microwave (MWA) in treatment unresectable colorectal liver metastases (CRLM) proximity to large vessels and/or major bile ducts. A database search was performed include patients with histologically proven 18F–FDG–PET avid CRLM who were treated RFA or MWA between January 2001 September 2014 a single centre. All lesions that considered have peribiliary perivascular location included. Univariate logistic...
Background Irreversible electroporation (IRE), an ablative technique that uses high-voltage electrical pulses, has shown promise for eradicating tumors near critical structures, including blood vessels and bile ducts. Purpose To investigate the efficacy safety of IRE colorectal liver metastases (CRLMs) unsuitable resection or thermal ablation because proximity to structures further systemically administered treatments. Materials Methods Between June 2014 November 2018, participants with...
Irreversible electroporation (IRE) is a novel image-guided tumor ablation technique that has shown promise for the of lesions in proximity to vital structures such as blood vessels and bile ducts. The primary aim COLDFIRE-2 trial investigate efficacy IRE unresectable, centrally located colorectal liver metastases (CRLM). Secondary outcomes are safety, technical success, accuracy contrast-enhanced (ce)CT (18)F-FDG PET-CT detection local progression (LTP).In this single-arm, multicenter phase...
To assess specific imaging characteristics after irreversible electroporation (IRE) for locally advanced pancreatic carcinoma (LAPC) with contrast-enhanced (ce)MRI and ceCT, to explore the correlation of these development recurrence. Qualitative quantitative analyses data were performed on 25 patients treated percutaneous IRE LAPC. Imaging ablation zone ceCT ceMRI assessed over a 6-month follow-up period. Contrast ratio scores between pre- post-treatment compared. detect early markers...
Background Irreversible electroporation (IRE) and stereotactic ablative body radiotherapy (SABR) are cytoreductive therapies for locally advanced pancreatic cancer (LAPC). Both may signify immunogenic cell death. We aimed to compare systemic immune responses between the treatments. Methods As part of randomized phase II CROSSFIRE trial ( NCT02791503 ), comparing oncological efficacy IRE SABR in patients with LAPC, pre- post-treatment (2 weeks 3 months) peripheral blood samples were...
In percutaneous ablation procedures, periprocedural pain, unrest and respiratory concerns can be detrimental to achieve a safe efficacious impair treatment outcome. This study aimed compare the association between anesthetic technique local disease control in patients undergoing microwave (MWA) of colorectal liver metastases (CRLM) hepatocellular carcinoma (HCC). IRB-exempted single-center comparative, retrospective analysis three cohorts analyzed 90 treated for hepatic malignancies from...
Introduction The majority of patients with perihilar cholangiocarcinoma (PHC) has locally advanced disease or distant lymph node metastases on presentation exploratory laparotomy, which makes them not eligible for resection. As the prognosis PHC in palliative setting is significantly better compared organ metastases, ablative therapies may be beneficial. Unfortunately, current options are limited. Photodynamic therapy causes skin phototoxicity and thermal methods, such as stereotactic body...
Irreversible electroporation (IRE) induces apoptosis with high-voltage electric pulses. Although the working mechanism is non-thermal, development of secondary Joule heating occurs. This study investigated whether observed conductivity rise during IRE caused by increased cellular permeabilization or heat development.IRE was performed in a gelatin tissue phantom, potato tubers, and 30 patients unresectable colorectal liver metastases (CRLM). Continuous versus sequential pulsing protocols...
Irreversible electroporation (IRE) is a novel image-guided ablation technique that rapidly gaining popularity in the treatment of malignant tumors located near large vessels or bile ducts. The presence metal objects zone, such as Wallstents, generally considered contraindication for IRE, because tissue heating due to power conduction may lead thermal complications. This report describes 66-year-old female with Bismuth–Corlette stage IV unresectable cholangiocarcinoma metallic Wallstent...