A5078635119- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Trauma and Emergency Care Studies
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Gallbladder and Bile Duct Disorders
- Sarcoma Diagnosis and Treatment
- Liver Disease and Transplantation
- Cardiac Arrest and Resuscitation
- Colorectal Cancer Treatments and Studies
- Organ Transplantation Techniques and Outcomes
- Abdominal Trauma and Injuries
- Metastasis and carcinoma case studies
- Lung Cancer Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Biliary and Gastrointestinal Fistulas
- Cancer Diagnosis and Treatment
University of Miami
2016-2025
Jackson Memorial Hospital
2011-2025
Sylvester Comprehensive Cancer Center
2016-2025
University of Miami Health System
2022
University of Cincinnati
2019
University of Miami Hospital
1978-2017
American College of Surgeons
2014-2016
American Association for the Surgery of Trauma
2011-2016
May Institute
2016
United States Army Medical Research and Development Command
2016
Abstract Uveal melanoma (UM) is a highly metastatic cancer that, in contrast to cutaneous melanoma, largely unresponsive checkpoint immunotherapy. Here, we interrogate the tumor microenvironment at single-cell resolution using scRNA-seq of 59,915 and non-neoplastic cells from 8 primary 3 samples. Tumor reveal novel subclonal genomic complexity transcriptional states. Tumor-infiltrating immune comprise previously unrecognized diversity cell types, including CD8 + T predominantly expressing...
In Brief Objective: To define the prognostic significance of surgical center case volume on outcome for soft tissue sarcoma (STS). Methods: STS cases registered in Florida Cancer Data System (FCDS) between 1981 and 2001 were analyzed. Medical facilities ranked by operative volume. Facilities above 67th percentile defined as high-volume centers (HVCs). Results: Of 4205 identified, 68.1% treated at low-volume (LVCs) 31.9% HVCs. A larger proportion high-grade tumors (53.8% vs. 44.3%) lesions...
Differences in cancer survival based on race, ethnicity, and socioeconomic status (SES) are a major issue. To identify points of intervention improve survival, the authors sought to determine impact for patients with cancers head neck (HN).HN diagnosed between 1998 2002 were examined using linked Florida Cancer Data System Agency Health Care Administration data set.A total 20,915 HN identified, predominantly oral cavity larynx. Overall, 72% male, 89.7% white, 8.4% African American (AA),...
To compare the survival outcomes associated with clinical and pathological response in pancreatic ductal adenocarcinoma (PDAC) patients receiving neoadjuvant chemotherapy (NAC) FOLFIRINOX (FLX) or gemcitabine/nab-paclitaxel (GNP) followed by curative-intent pancreatectomy.Newer multiagent NAC regimens have resulted improved responses PDAC; however, effects of these on remain unknown.Clinicopathological data PDAC treated at 7 academic medical centers were analyzed. Primary overall (OS), local...
This study tested the hypothesis that early routine use of tranexamic acid (TXA) reduces mortality in a subset most critically injured trauma intensive care unit patients.Consecutive patients (n = 1,217) who required emergency surgery (OR) and/or transfusions from August 2009 to January 2013 were reviewed. At surgeon discretion, TXA was administered at median 97 minutes (1-g bolus then 1-g over 8 hours) 150 deemed high risk for hemorrhagic death. With propensity scores based on age, sex,...
Timely hemorrhage control is paramount in trauma; however, a critical time interval from emergency department arrival to operation for hypotensive gunshot wound (GSW) victims not established. We hypothesize that delaying surgery more than 10 minutes increases all-cause mortality patients with GSW.Data of adults (n = 309) hypotension and GSW the torso requiring immediate January 2004 September 2013 were retrospectively reviewed. Patients resuscitative thoracotomies, traumatic brain injury,...
From 1983 through 1997, our center diagnosed 130 cases of benign neoplasms: 27 with focal nodular hyperplasia (FNH), 25 hepatic adenoma, 71 cavernous hemangioma, and seven mixed tumors different diagnoses. Most often these lesions were seen in females [female-to-male ratio (f/m): 5.5/1]. Hepatic adenomas exclusively FNH predominantly (f/m: 26/1). Hemangiomas, however, not uncommon men 52/19) relative to the other (P < 0.001). Furthermore patients hemangioma older (mean age: 49 years) whereas...
In Brief Objective: To describe a single-center experience of pediatric intestinal transplantation (Itx) and to provide an overview the children who underwent this procedure along with their outcomes. Summary Background Data: Pediatric Itx presents multiple challenges because very young ages at which patients require higher susceptibility infectious complications. Methods: We have performed 141 in 123 median age 1.37 years. Primary grafts included isolated intestine (n = 28), liver 27),...
Esophageal adenocarcinoma ranks sixth in cancer mortality the world and its incidence has risen dramatically Western population over last decades. Data presented herein strongly suggest that Notch signaling is critical for esophageal underlies resistance to chemotherapy. We present evidence drives a stem cell phenotype by regulating genes establish stemness. Using patient-derived xenograft models, we demonstrate inhibition of gamma-secretase inhibitors (GSI) efficacious downsizing tumor...
The optimal long-term regimen for immunosuppression kidney transplant recipients is unknown. We conducted a randomized trial involving 150 to compare tacrolimus/sirolimus, tacrolimus/mycophenolate mofetil (MMF), and cyclosporine/sirolimus. All patients received daclizumab induction maintenance corticosteroids. Median follow-up was 8 yr post-transplant. Acute rejection (AR) occurred significantly less often among those treated with tacrolimus/MMF (12%) than tacrolimus/sirolimus (30%) or...