A5081025967- Hedgehog Signaling Pathway Studies
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Wnt/β-catenin signaling in development and cancer
- Autophagy in Disease and Therapy
- Viral gastroenteritis research and epidemiology
- Cancer-related Molecular Pathways
- Parkinson's Disease Mechanisms and Treatments
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Animal Virus Infections Studies
- Histone Deacetylase Inhibitors Research
- Genomics and Chromatin Dynamics
- Microtubule and mitosis dynamics
- Cell death mechanisms and regulation
- Esophageal Cancer Research and Treatment
- Immune cells in cancer
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Metabolomics and Mass Spectrometry Studies
Foshan Hospital of TCM
2025
Guangzhou University of Chinese Medicine
2025
Jiangsu Academy of Agricultural Sciences
2016-2025
Yangzhou University
2021-2025
Nanchang University
2022-2025
Dalian Medical University
2020-2025
Ganzhou People's Hospital
2025
University of Miami
2014-2024
First Affiliated Hospital of Jiangxi Medical College
2024
University of Science and Technology of China
2009-2024
Parkin is an E3 ubiquitin ligase that mediates the ubiquitination of protein substrates. The mutations in parkin gene can lead to a loss function and cause autosomal recessive juvenile onset parkinsonism. Recently, was reported be involved regulation mitophagy. Here, we identify Bcl-2, anti-apoptotic autophagy inhibitory protein, as substrate for parkin. directly binds Bcl-2 via its C terminus mono-ubiquitination which increases steady-state levels Bcl-2. Overexpression parkin, but not...
Epigenetic enzymes modulate signal transduction pathways in different biological contexts. We reasoned that epigenetic regulators might the Hedgehog (HH) signaling pathway, a main driver of cell proliferation various cancers including medulloblastoma. To test this hypothesis, we performed an unbiased small-molecule screen utilizing HH-dependent reporter line (Light2 cells). incubated Light2 cells with small molecules targeting modulators and identified four histone deacetylase inhibitors...
Esophageal adenocarcinoma ranks sixth in cancer mortality the world and its incidence has risen dramatically Western population over last decades. Data presented herein strongly suggest that Notch signaling is critical for esophageal underlies resistance to chemotherapy. We present evidence drives a stem cell phenotype by regulating genes establish stemness. Using patient-derived xenograft models, we demonstrate inhibition of gamma-secretase inhibitors (GSI) efficacious downsizing tumor...
The Hedgehog (HH) signaling pathway represents an important class of emerging developmental pathways that play critical roles in the genesis a large number human cancers. pharmaceutical industry is currently focused on developing small molecules targeting Smoothened (Smo), key effector HH regulates levels and activity Gli family transcription factors. Although one these compounds, vismodegib, now FDA-approved for patients with advanced basal cell carcinoma, acquired mutations Smo can result...
Rotaviruses (RVs) are the leading cause of severe gastroenteritis in young children, accounting for half a million deaths annually worldwide. RV encodes non-structural protein 1 (NSP1), well-characterized interferon (IFN) antagonist, which facilitates virus replication by mediating degradation host antiviral factors including IRF3 and β-TrCP. Here, we utilized six human animal NSP1s as baits performed tandem-affinity purification coupled with high-resolution mass spectrometry to...
Non-small-cell carcinoma (NSCLC) is the most common cancer along with high mortality rate worldwide. In present study, our data showed that lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAFG-AS1) was over-expressed in NSCLC tissues and cell lines. Overexpression of MAFG-AS1 promoted migration, invasion enhanced epithelial-mesenchymal transition (EMT) cell. addition, miR-339-5p predicted to be a target level down-regulated NSCLC. Over-expression significantly decreased Moreover,...
Mutations in the WNT-pathway regulator ADENOMATOUS POLYPOSIS COLI (APC) promote aberrant activation of WNT pathway that is responsible for APC-associated diseases such as Familial Adenomatous Polyposis (FAP) and 85% spontaneous colorectal cancers (CRC). FAP characterized by multiple intestinal adenomas, which inexorably result CRC. Surprisingly, given their common occurrence, there are few effective chemotherapeutic drugs FAP. Here we show FDA-approved, anti-helminthic drug Pyrvinium...
In recent years, porcine diarrhea-associated viruses have caused significant economic losses globally. These present similar clinical symptoms, such as watery diarrhea, dehydration, and vomiting. Co-infections with epidemic diarrhea virus (PEDV) transmissible gastroenteritis (TGEV) are common. For the rapid on-site preliminary diagnosis on pig farms, this study aimed to develop a colloidal gold immunochromatography assay (GICA) strip for detection of PEDV TGEV simultaneously. The GICA kit...
Four saponins could efficiently modulate the immune response against PEDV and hold promise for utilization in antiviral treatments.
To investigate the association between presence of HMCAS on CT prior MT and occurrence poor functional outcomes sHT in LVO patients attributed to CE LAA etiology. We conducted a retrospective analysis using patient data from three comprehensive stroke centers. Patients were categorized into four groups: (1) with HMCAS, (2) no (3) cardioembolic (4) based underlying compared 90-day modified Rankin score (mRS) incidence 1 vs. 2, 3 4. 295 included, which 93 (31.5%) exhibited HMCAS. associated...
Lung cancer is one of the most common types and causes 1.38 million deaths annually, as 2008 worldwide. Identifying natural anti-lung agents has become very important. Gambogenic acid (GNA) active compounds Gamboge, a traditional medicine that was used drastic purgative, emetic, or vermifuge for treating tapeworm. Recently, increasing evidence indicated GNA exerts promising anti-tumor effects; however, underlying mechanism remains unclear. In present paper, we found could induce formation...
Background: The aberrant activation of the Sonic hedgehog (Shh) signaling pathway is involved in progression several types cancer, including gastric cancer (GC). However, it remains uncertain whether also plays a critical role promoting initiation and by inducing epithelial-to-mesenchymal transition (EMT) GC. Thus, aim present study was to determine Shh GC, investigate function induction EMT Materials methods: expression levels members markers were examined GC tissues immunohistochemistry....