A5086445322- Cancer-related molecular mechanisms research
- Aquaculture disease management and microbiota
- RNA modifications and cancer
- Immune Response and Inflammation
- Electrical and Bioimpedance Tomography
- Neurotransmitter Receptor Influence on Behavior
- Ferroptosis and cancer prognosis
- interferon and immune responses
- Autophagy in Disease and Therapy
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related gene regulation
- Microfluidic and Bio-sensing Technologies
- Cancer, Hypoxia, and Metabolism
- Cannabis and Cannabinoid Research
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Immune cells in cancer
- Invertebrate Immune Response Mechanisms
- Hepatitis B Virus Studies
- RNA Interference and Gene Delivery
- Flow Measurement and Analysis
- Memory and Neural Mechanisms
Zhejiang University
2025
Affiliated Hospital of North Sichuan Medical College
2021-2025
University of South China
2020-2024
Central South University
2024
Shaanxi Provincial People's Hospital
2024
Third Xiangya Hospital
2024
Shanxi Medical University
2024
Ningbo University Affiliated Hospital
2023-2024
Institute of Bast Fiber Crops
2023
Chinese Academy of Agricultural Sciences
2023
Abstract Nucleotide oligomerization domain–like receptors (NLRs) and RIG-I–like (RLRs) detect diverse pathogen-associated molecular patterns to activate the innate immune response. The role of mammalian NLR NOD1 in sensing bacteria is well established. Although several studies suggest also plays a viruses, mechanisms behind this are still largely unknown. In study, we report on synergism antagonism between MDA5 isoforms teleost. zebrafish, overexpression enhances antiviral response mRNA...
Resistance toward imatinib (IM) and other BCR/ABL tyrosine kinase inhibitors remains troublesome in the treatment of advanced stage chronic myeloid leukemia (CML). The aim this study was to estimate reversal effects down-regulation Na(+)/H(+) exchanger 1 (NHE1) on chemoresistance BCR-ABL-positive patients' cells cell lines. After with specific NHE1 inhibitor cariporide decrease intracellular pH (pHi), heme oxygenase-1 (HO-1) levels K562R line from IM-insensitive CML patients decreased. HO-1,...
Abstract Background Diabetic foot ulcers (DFU) are a serious complication of diabetes that lead to significant morbidity and mortality. Recent studies reported exosomes secreted by human adipose tissue-derived mesenchymal stem cells (ADSCs) might alleviate DFU development. However, the molecular mechanism ADSCs-derived in is far from being addressed. Methods Human umbilical vein endothelial (HUVECs) were induced high-glucose (HG), which treated with derived nuclear factor I/C (NFIC)-modified...
Methamphetamine (METH), a commonly used controlled substance, is known to exacerbate neuropathological dysfunction in HIV-infected individuals. The manifestation results from cell death or the central nervous system (CNS) wherein autophagy expected have an important role. Autophagy generally considered protective during deprivation/stress. However, excessive can be destructive, leading autophagic death. This study was designed investigate if METH and HIV-1 gp120 interact induce SVGA...
Gallbladder cancer (GBC) is one of the most common and aggressive biliary tract cancers with a dismal prognosis. Ongoing clinical trials are evaluating few selected immune checkpoint inhibitors (ICIs) as monotherapy for treatment GBC patients. However, only subset patients benefits from these treatments. To improve ICI therapy response, molecular mechanisms that confer resistance to (IC) blockade needs be explored. Epithelial-to-mesenchymal transition (EMT) program stem cells (CSCs) have...
Microliposome maintenance (MCM) 2, MCM3, MCM4, MCM5, MCM6, and MCM7 are DNA replication regulators involved in the progression of multiple cancer types, but their role ovarian is still unclear. The purpose this study to clarify biological function prognostic value MCM complex (OS) progression. We analyzed alterations, mRNA protein levels, structure, PPI network, functional enrichment, OC based on Oncomine, cBioPortal, TCGA, CPTAC, PDB, GeneMANIA, DAVID, KEGG, GSCALite databases. results...
Relapse to drug seeking can be caused by exposure drug-associated cues, provoking craving even after prolonged abstinence. Recent studies demonstrated that AMP-activated protein kinase (AMPK) regulates neuronal morphology and membrane excitability in neurons. Here, we investigated the role of AMPK activity nucleus accumbens (NAc) relapse cocaine seeking. We found drug-related cues reinstated cocaine-seeking behavior increased p70s6k phosphorylation NAc core but not shell. Augmenting...
Our previous studies demonstrated that xyloketal B, a novel marine compound with unique chemical structure, has strong antioxidant actions and can protect against endothelial injury in different cell types cultured vitro model organisms vivo. The oxidative dysfunction decrease nitric oxide (NO) bioavailability are critical for the development of atherosclerotic lesion. We thus examined whether B had an influence on plaque area apolipoprotein E-deficient (apoE-/-) mice fed high-fat diet...
To investigate the effect of homocysteine (Hcy) on intestinal permeability in rats with TNBS/ethanol-induced colitis and elucidate its mechanism.Sprague-Dawley were divided into four groups: normal, normal + Hcy injection, TNBS model, model injection. Experimental was induced by trinitrobenzene sulfonic acid (TNBS) 50% ethanol; injected subcutaneously from first day after induction experimental 30 consecutive days. determine severity colitis, disease activity index (DAI) evaluated; colon...
Pulsed electromagnetic fields (PEMF) have been proven to be effective for promoting bone mass and regulating turnover both experimentally clinically. However, the exact mechanisms regulation of PEMF on osteoclastogenesis as well optical exposure parameters inhibiting osteoclastic activities functions remain unclear, representing significant limitations extensive scientific application in clinics. In this study, RAW264.7 cells incubated with RANKL were exposed 15 Hz (2 h/day) at various...
RIP2 is an adaptor protein which essential for the activation of NF-κB, and NOD1- NOD2-dependent signaling. Although NOD-RIP2 axis conservatively existed in teleost, function was only reported zebrafish, goldfish rainbow trout vitro. Very little known about role mechanisms piscine vivo. Our previous study showed protective zebrafish NOD1 larval survival through CD44a-mediated PI3K-Akt In present study, we examined whether required with or without pathogen infection, determined signaling...
Electrical impedance tomography (EIT) is a noninvasive, radiation-free, and low-cost imaging modality for monitoring the conductivity distribution inside patient. Nowadays, time-difference EIT (tdEIT) used extensively as it has fast speed can reflect dynamic changes of diseases, which make attractive number medical applications. Moreover, modeling errors are compensated to some extent by subtraction voltage measurements collected before after change. However, tissue varies with frequency...
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy associated with steadily increasing incidence and poor prognosis. Ongoing clinical trials are assessing the effectiveness safety of few immune checkpoint inhibitors (ICIs) in CCA patients. However, these ICI treatments as monotherapies may be effective for proportion patients CCA. The prevalence distribution other checkpoints (ICs) remain unclear. In this pilot study, we screened databases expression 19 ICs assessed prognostic...
Opioid use disorder (OUD) is a chronic relapsing psychiatric disorder. An unconditioned stimulus (US)-triggers memory reconsolidation updating procedure (MRUP) that has been developed and demonstrated its effectiveness in decreasing relapse to cocaine heroin preclinical models. However, utilizations of abused drugs as the US initiate MRUP can be problematic. We therefore designed translational rat study human evaluate efficacy novel methadone-initiated MRUP.