A5108050255- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- interferon and immune responses
- Covalent Organic Framework Applications
- Advanced Photocatalysis Techniques
- Air Quality and Health Impacts
- Cancer-related gene regulation
- Circular RNAs in diseases
- Immune cells in cancer
- Microtubule and mitosis dynamics
- Extracellular vesicles in disease
- Heme Oxygenase-1 and Carbon Monoxide
- Plant Pathogenic Bacteria Studies
- Stress Responses and Cortisol
- Invertebrate Taxonomy and Ecology
- Cancer, Hypoxia, and Metabolism
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Selenium in Biological Systems
- Genomics and Phylogenetic Studies
- Antimicrobial Peptides and Activities
Shaanxi Normal University
2023-2025
Jilin University
2022-2025
Wuhan University
2019-2024
John F. Kennedy Medical Center
2024
Jiangsu University
2020-2024
Affiliated Hospital of Jiangsu University
2024
Wuhan Institute of Virology
2021-2024
Guangzhou Medical University
2022-2024
Southern Medical University
2023-2024
Yangzhou University
2022-2024
Rationale The majority of drug abusers are incapable sustaining abstinence over any length time. Accumulating evidence has linked intense and involuntary craving, Impulsive decision-making mood disturbances to risk for relapse. However, little is known about temporal changes these neuropsychological functions in methamphetamine (METH)-dependent individuals. Objectives To investigate the effect on decision-making, craving (baseline cue-induced), emotional state METH-addicted Methods In this...
A novel benzotrifuranyl COF with excellent photovoltaic properties and low exciton binding energy was successfully constructed used for efficient photolysis of water.
Early visual deprivation can lead to changes in the brain, which may be explained by either of two hypotheses. The general loss hypothesis has been proposed explain maladjustments, while compensatory plasticity a superior ability use remaining senses. Most previous task-based functional MRI (fMRI) studies have supported hypothesis, but it difficult provide evidence support since blind cannot execute tasks. study resting state fMRI data an opportunity simultaneously detect aspects blind. In...
<h3>Abstract</h3> Ataxia telangiectasia (A-T) is a multisystemic disease caused by mutations in the ATM (A-T mutated) gene. It strikes before 5 years of age and leads to dysfunctions many tissues, including CNS, where it neurodegeneration, primarily cerebellum. Alzheimer's (AD), contrast, largely sporadic neurodegenerative disorder that rarely 7th decade life with primary neuronal losses hippocampus, frontal cortex, certain subcortical nuclei. Despite these differences, we present data...
Autophagy is involved in the pathogenesis of neurodegenerative diseases including Parkinson disease (PD). However, little known about regulation autophagy process. In this study, we characterized aberrant activation induced by neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) and demonstrated that melatonin has a protective effect on neurotoxicity. We found an excessive monkey brain tissues C6 cells, MPTP, which mediated CDK5 (cyclin-dependent kinase 5). MPTP treatment...
Animal models of COVID-19 facilitate the development vaccines and antivirals against SARS-CoV-2. The efficacy or may differ in different animal with varied degrees disease. Here, we introduce a mouse model expressing human angiotensin-converting enzyme 2 (ACE2). In this model,
Abstract Background As one of the most common malignancy, lung adenocarcinoma (LUAD) is characterized by low 5-year survival rate. This research aimed to investigate effects ribonucleotide reductase regulatory subunit M2 (RRM2) on malignant biological behaviors and activation cGAS/STING pathway. We also explored synergistic sensitization mechanisms RRM2 radiotherapy. Methods Bioinformatic tools were used evaluate clinical significance in LUAD patients. The roles phenotype DNA damage cells...
Chronic hepatitis B virus (HBV) infection is a major cause of liver cirrhosis and cancer, despite strong prevention treatment efforts. The study the epigenetic modification HBV has become research hotspot, including N 6-methyladenosine (m 6 A) RNA, which plays complex roles in life cycle. In addition to m A modification, 5-methylcytosine 5 C) another eukaryotic mRNA. this study, we explored C methyltransferase demethyltransferase results showed that NSUN2 deficiency could negatively regulate...
Methylmercury (MeHg) is a global environmental pollutant with neurotoxicity, which can easily crosses the blood–brain barrier and cause irreversible damage to human central nervous system (CNS). CNS inflammation autophagy are known be involved in pathology of neurodegenerative diseases. Meanwhile, MeHg has potential induce microglia-mediated neuroinflammation as well autophagy. This study aims further explore exact molecular mechanism neurotoxicity. We conducted vitro studies using BV2...
Human adenovirus (HAdV) can cause severe respiratory infections in immunocompromised patients, but its clinical treatment is seriously limited by side effects of drugs such as poor efficacy, low bioavailability and nephrotoxicity. Trace element selenium (Se) has been found will affect the disease progression pneumonia, antivirus efficacy could be improved speciation optimization. Therefore, herein we performed anti-HAdV different Se that lentinan (LNT)-decorated nanoparticles (SeNPs)...
The release and nuclear translocation of the intracellular domain Notch receptor (NICD) is prerequisite for signaling-mediated transcriptional activation. NICD subjected to various posttranslational modifications including ubiquitination. Here, we surprisingly found that NUMB proteins stabilize NOTCH1 (N1ICD) by regulating ubiquitin-proteasome machinery, which independent NUMB's role in modulating endocytosis. BAP1, a deubiquitinating enzyme (DUB), was further identified as positive N1ICD...
Circular RNAs (circRNAs) are abundant in mammalian brain and some show age-dependent expression patterns. Here, we report that circGRIA1, a conserved circRNA isoform derived from the genomic loci of α-mino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit Gria1, shows an age-related male-specific increase rhesus macaque prefrontal cortex hippocampus. We circGRIA1 is predominantly localized to nucleus, find its association with promoter region Gria1 gene, suggesting it has...
Platelet activation contributes to sepsis development, leading microthrombosis and increased inflammation, which results in disseminated intravascular coagulation multiple organ dysfunction. Although Cathelicidin can alleviate sepsis, its role regulation remains largely unexplored. In this study, we identified Cath-HG, a novel from Hylarana guentheri skin, analyzed structure using nuclear magnetic resonance spectroscopy. The modulatory effect of Cath-HG on the symptoms mice with induced by...
2D covalent organic frameworks (2D-COFs) have attracted extensive interest in solar energy to hydrogen conversion. However, insufficient light harvesting and difficult exciton dissociation severely limit the improvement of photocatalytic activity for COFs, thereby impeding progression this advanced field. In work, two benzobisoxazole-bridged fully conjugated 2D-COFs with triazine (COF-JLU44) pyrene (COF-JLU45) units were constructed first time via Knoevenagel polycondensation, they hold...
Abstract 2D covalent organic frameworks (2D‐COFs) have attracted extensive interest in solar energy to hydrogen conversion. However, insufficient light harvesting and difficult exciton dissociation severely limit the improvement of photocatalytic activity for COFs, thereby impeding progression this advanced field. In work, two benzobisoxazole‐bridged fully conjugated 2D‐COFs with triazine (COF‐JLU44) pyrene (COF‐JLU45) units were constructed first time via Knoevenagel polycondensation, they...
Prions consist mainly of PrP Sc , a pathogenic conformer host-encoded C . Prion populations with distinct phenotypes but associated having the same amino acid sequence, constitute strains. Strain identity is thought to be encoded by conformation and maintained seeded conversion. strains can distinguished cell panel assay, which measures their ability infect lines. Brain-derived 22L prions characteristically are able R33 cells (i.e., “R33 competent”), as well PK1 in presence inhibitor...