A5100386054- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Prostate Cancer Treatment and Research
- Plant-Microbe Interactions and Immunity
- Gut microbiota and health
- Medical Education and Admissions
- Global Health Workforce Issues
- Ginseng Biological Effects and Applications
- Cancer Mechanisms and Therapy
- DNA Repair Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Phagocytosis and Immune Regulation
- CRISPR and Genetic Engineering
- Inflammatory Bowel Disease
- Immune Cell Function and Interaction
- Fungal and yeast genetics research
- Autophagy in Disease and Therapy
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Plant tissue culture and regeneration
Northwest A&F University
2023-2025
Central South University
2023-2025
Jining Medical University
2020-2024
Second Hospital of Anhui Medical University
2023-2024
Anhui Medical University
2018-2024
Peking University Shenzhen Hospital
2020-2024
Chinese Academy of Agricultural Sciences
2023
Peking Union Medical College Hospital
2023
Chinese PLA General Hospital
2023
Beijing Shijitan Hospital
2023
Osteoarthritis (OA) is a chronic disease pathologically characterized by articular cartilage degeneration and damage. Currently, studies have found that circular RNA (circRNA) involved in intracellular regulating network closely related to the occurrence development of diseases, therefore it may become new biological marker therapeutic target. After stimulating chondrocytes with interleukin-1 beta (IL-1β), hsa_circ_0005105 expression was significantly upregulated, while miR-26a inhibited....
Circular RNAs (circRNAs) are emerging as cardinal areas of focus in the non-coding RNA field. Growing evidences have revealed exosomal circRNAs potential biomarkers for detection various cancers. However, clinical importance most serum colorectal cancer (CRC) rarely been investigated. In this study, we examined possible application diagnosis CRC. Firstly, conducted sequencing (RNA-seq) analysis using fifty CRC and healthy control samples to identify CRC-related circRNAs. The data showed 122...
Circular RNAs (circRNAs) are abundant in mammalian brain and some show age-dependent expression patterns. Here, we report that circGRIA1, a conserved circRNA isoform derived from the genomic loci of α-mino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit Gria1, shows an age-related male-specific increase rhesus macaque prefrontal cortex hippocampus. We circGRIA1 is predominantly localized to nucleus, find its association with promoter region Gria1 gene, suggesting it has...
ABSTRACT Nuclease 1 (NUC1) is a highly conserved nonspecific endonuclease present in vertebrates, fungi, and few plant species. While the involvement of yeast NUC1p apoptotic cell death independent metacaspase or apoptosis‐inducing factors documented, its function other particularly pathogenic ones, remains elusive. In this study, we identified characterised homologue NUC1p, termed PstNUC1, Puccinia striiformis f. sp. tritici ( Pst ), causal agent wheat stripe rust. PstNUC1 was induced...
Natural killer (NK) cell-derived exosomes (NK-Exos) are emerging as a promising avenue in cancer immunotherapy due to their inherent tumor-targeting properties and capacity deliver therapeutic agents directly malignant cells. This research delves into the boosted anti-tumor potency of NK-Exos that has been genetically enhanced overexpress NKG2D, vital activating receptor, along with interleukin-24 (IL24), cytokine renowned for its selective suppressive impact on tumor NKG2D facilitates...
Background: Hepatocellular carcinoma (HCC) is the leading cause of tumor-associated death in males and females worldwide. HCC mostly diagnosed at advanced stages chemotherapeutic cisplatin one major therapeutic options treatment patients with treating HCC. Despite several reports on multidrug resistance, underlying regulatory mechanisms are still unclear. Methods: RT-PCR was performed to detect circRNA_102272, miR-326 RUNX2 expression. The CCK8 assay used examine cell proliferation IC 50...
Circular RNAs (circRNAs) are a class of conserved, endogenous non-coding that involved in transcriptional and post-transcriptional gene regulation highly enriched the nervous system. They participate survival differentiation multiple nerve cells, may even promote recovery neurological function after stroke. However, their role inflammatory response spinal cord injury remains unclear. In present study, we established mouse model T9 using modified Allen's impact method, identified 16,013...
Sini Decoction (SND), as a classic prescription of Traditional Chinese Medicine (TCM), has been proved to be clinically useful in cardiomyopathy and inflammatory bowel diseases. However, the role mechanism SND colitis-associated cancer remains unclear. This study aims evaluate effect on colorectal cancer(CRC) symptoms further explore changes gut microbes mediated by extract azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mice through 16 S rRNA sequencing. Our results indicated...
Circular RNAs (circRNAs) are a group of regulators that affect the aggressive behaviors several types cancer. Hsa_circ_0001666 (also referred to as hsa_circ_000742) is newly discovered circRNA upregulated in human papillary thyroid carcinoma (PTC) based on microarray analysis. However, role hsa_circ_0001666 PTC progression remains unknown. Thus, aim present study was determine potential function and underlying mechanism PTC. The results demonstrated both clinical samples cell lines. Its...
Paeoniflorin (PF) is the primary component derived from <em>Paeonia lactiflora</em> and white peony root has been used widely for treatment of ulcerative colitis (UC) in China. UC primarily manifests as a chronic inflammatory response intestine. In present study, network pharmacology approach was to explore specific effects underlying mechanisms action PF UC. A research strategy based on pharmacology, combining target prediction, construction, Gene Ontology (GO), Kyoto Encyclopedia Genes...
Increasing evidence suggests that circular RNAs (circRNAs) play a major role in tumorigenesis and cancer progression. This study aimed to identify aberrant expression of hsa_circ_0003829 oral squamous cell carcinoma (OSCC) explore its clinical significance.We conducted prospective examine the pattern 60 paired OSCC normal samples lines using real-time quantitative polymerase chain reaction. We also evaluated diagnostic value based on receiver operating characteristic (ROC) curve analysis,...
Accumulating data have established that microRNAs (miRNAs) play significant regulatory roles in the carcinogenesis and progression of ovarian cancer (OC). MiR-425-5p was reported to function various tumors. However, underlying mechanism miR-425-5p involvement OC development are unclear.A comprehensive strategy mining, computational biology, real-time polymerase chain reaction employed identify progression. The effect on proliferation, migration, invasion cells determined using Cell Counting...