A5103093157- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Animal Virus Infections Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Gut microbiota and health
- Advanced biosensing and bioanalysis techniques
- Dietary Effects on Health
- Immunotherapy and Immune Responses
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Tryptophan and brain disorders
- Drug-Induced Hepatotoxicity and Protection
- interferon and immune responses
- Hepatitis C virus research
- Circadian rhythm and melatonin
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
Sir Run Run Shaw Hospital
2020-2024
Zhejiang University
2020-2024
Our work revealed that A. muciniphila attenuated APAP-induced liver injury by alleviating oxidative stress and inflammation in the liver, its hepatoprotective effect was accompanied activation of PI3K/Akt pathway mediated regulation composition metabolic function intestinal microbiota. This finding suggested microbial community is a non-negligible impact on drug metabolism probiotic administration could be potential therapy for drug-induced injury.
Metastasis, especially intrahepatic, is a major challenge for hepatocellular carcinoma (HCC) treatment. Cytoskeleton remodeling has been identified as vital process mediating intrahepatic spreading. Previously, we reported that HCC tumor adhesion and invasion were modulated by circular RNA (circRNA), which emerged an important regulator of various cellular processes implicated in cancer progression. Here, uncovered nuclear circRNA, circASH2, preferentially lost tissues inhibits metastasis...
Circular RNAs (circRNAs) have emerged as important regulators of various cellular processes and been implicated in cancer. Previously, we reported the discovery several dysregulated circRNAs including circPABPC1 (polyadenylate-binding protein 1) human hepatocellular carcinoma (HCC), although their roles HCC development remained unclear. Here, show that is preferentially lost tumor cells from clinical samples inhibits both intrahepatic distant metastases a mouse xenograft model. This...
With the drive of endogenous circadian clock and external cues such as feeding behavior, microbial community generates rhythmic oscillations in composition function. Microbial are crucial orchestrating host metabolic homeostasis during predictable 24-hour diurnal cycle. A time-restricted (TRF) regimen is a promising dietary strategy to optimize energy utilization, alleviate syndrome reinforce cyclical fluctuations. However, causative relationship between reinforced rhythmicity TRF-induced...
Abstract Circular RNAs (circRNAs) have emerged as crucial regulators in physiology and human diseases. However, evolutionarily conserved circRNAs with potent functions cancers are rarely reported. In this study, a mammalian circRNA circLARP1B is identified to play critical roles hepatocellular carcinoma (HCC). Patients high levels advanced prognostic stage poor overall survival. CircLARP1B facilitates cellular metastatic properties lipid accumulation through promoting fatty acid synthesis...
Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with gender-related differences in onset and course. Androgen receptor (AR), male hormone receptor, critical the initiation progression of HCC. The role AR HCC has been mechanistically characterized anti-AR therapies have developed, showing limited efficacy. Immunotherapy targeting immune checkpoint proteins may substantially improve clinical management mechanism by which influences state remains unclear. In this study, we...
Background The physiological regulatory functions of circRNAs have become a topic intensive research in recent years. Increasing evidence supports significant role during cancer initiation and progression, including hepatocellular carcinoma (HCC). Materials Methods A bioinformatics analysis from three independent Gene Expression Omnibus (GEO) databases was performed to profile screen the dysregulated HCC. RT-qPCR used examine expression level circUBAP2 HCC adjacent non-tumor tissues. Then,...
Cuproptosis, a distinct form of programmed cell death, is an emerging field in oncology with promising implications. This novel mode death has the potential to become regulatory target for tumor therapy, thus expanding currently limited treatment options available patients cancer. Our research team focused on investigating role functional long non-coding RNA (lncRNAs) hepatocellular carcinoma (HCC). We were particularly intrigued by implications HCC-lncRNAs cuproptosis. Through comprehensive...
Abstract Background Nonalcoholic steatohepatitis (NASH) occupies a substantial proportion of chronic liver disease worldwide, which pathogenesis needs further research. Recent studies have demonstrated the significant roles circular RNAs (circRNAs) in NASH, while function novel type circRNAs, namely mitochondria-encoded circRNAs (mecciRNAs), remains elusive. Therefore, we aimed to investigate their potential regulate progression NASH this study. Methods GSE134146 was used screen for...
Abstract Hepatitis B e antigen (HBeAg) seropositivity during the natural history of chronic hepatitis (CHB) is known to coincide with significant increases in serum and intrahepatic HBV DNA levels. However, precise underlying mechanism remains unclear. In this study, we found that PreC (HBeAg precursor) genetic ablation leads reduced viral replication both vitro vivo. Furthermore, impedes proteasomal degradation polymerase, promoting replication. We discovered interacts SUV39H1, a histone...
Abstract Background Nonalcoholic steatohepatitis (NASH) occupies a substantial proportion of chronic liver disease worldwide, which pathogenesis needs further research. Recent studies have demonstrated the significant roles circular RNAs (circRNAs) in NASH, while function novel type circRNAs, namely mitochondria-encoded circRNAs (mecciRNAs), still remain elusive. Therefore, we aimed to investigate their potential regulate progression NASH this study. Methods GSE134146 was used screen for...
Abstract Background Recently, a novel, different from the known mechanisms, copper-dependent cell death-"cuproptosis" was demonstrated. However, regulation of cuproptosis, especially in malignancy, remains unclear. This study aimed to identify hepatocellular carcinoma-long noncoding RNAs (HCC-lncRNAs) closely related cuproptosis. Methods First, we identified lncRNAs that are associated with cuproptosis-related genes and abnormally expressed HCC. Subsequently, comprehensive methods Univariate...