A5101578842- Clinical Nutrition and Gastroenterology
- Radiomics and Machine Learning in Medical Imaging
- Enhanced Recovery After Surgery
- Organ Transplantation Techniques and Outcomes
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Surgical Treatments
- Immunotherapy and Immune Responses
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Organ and Tissue Transplantation Research
- Cancer-related molecular mechanisms research
- Biliary and Gastrointestinal Fistulas
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Colorectal Cancer Screening and Detection
- Appendicitis Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Protein Tyrosine Phosphatases
- Bariatric Surgery and Outcomes
- Fetal and Pediatric Neurological Disorders
- Abdominal Surgery and Complications
- Cerebrospinal fluid and hydrocephalus
- Hepatitis C virus research
- Genomics, phytochemicals, and oxidative stress
Sir Run Run Shaw Hospital
2013-2025
Zhejiang University
2013-2025
Huzhou University
2020-2022
Huzhou Central Hospital
2020-2022
Nanjing University
2010
Jinling Institute of Technology
2010
Nanjing General Hospital of Nanjing Military Command
2010
Stimuli-responsive nano-immunochemotherapy modulates the tumor microenvironment to enhance antitumor immunity.
Circular RNAs (circRNAs) have emerged as important regulators of various cellular processes and been implicated in cancer. Previously, we reported the discovery several dysregulated circRNAs including circPABPC1 (polyadenylate-binding protein 1) human hepatocellular carcinoma (HCC), although their roles HCC development remained unclear. Here, show that is preferentially lost tumor cells from clinical samples inhibits both intrahepatic distant metastases a mouse xenograft model. This...
Objective: The study aims to detect the potential relationship between iron deposition and function of glymphatic system in normal aging brain. Methods: We recruited 213 healthy participants. evaluated using index for diffusivity along perivascular space (ALPS-index), assessed on quantitative susceptibility mapping (QSM), analyzed their relationship. Results: mean age participants was 60.1 ± 7.3, 107 (50.2%) were female. ALPS-index 1.4 0.2. QSM values caudate nucleus, putamen, globus...
Background Laparoscopic sleeve gastrectomy (LSG) has emerged as a highly effective intervention in the management of obesity. While there been recent surge research exploring relationship between obesity and gut microbiota, association microbiota LSG remains relatively underexplored. This study aimed to investigate both early later effects LSG. Methods In this retrospective study, clinical characteristics preoperative fecal samples were collected from 52 individuals who underwent Using 16S...
Background The physiological regulatory functions of circRNAs have become a topic intensive research in recent years. Increasing evidence supports significant role during cancer initiation and progression, including hepatocellular carcinoma (HCC). Materials Methods A bioinformatics analysis from three independent Gene Expression Omnibus (GEO) databases was performed to profile screen the dysregulated HCC. RT-qPCR used examine expression level circUBAP2 HCC adjacent non-tumor tissues. Then,...
Lymphovascular invasion (LVI) and perineural (PNI) are independent prognostic factors in patients with colorectal cancer (CRC). In this study, we aimed to develop validate a preoperative predictive model based on high-throughput radiomic features clinical for accurate prediction of LVI/PNI these patients.Two hundred sixty-three who underwent resection histologically confirmed CRC between 1 February 2011 30 June 2020 were retrospectively enrolled. Between September 2018, 213 randomly divided...
Although rectal cancer comprises up to one-third of colorectal cases and several prognosis nomograms have been established for colon cancer, statistical tools predicting long-term survival in are lacking. In addition, previous prognostic studies did not include much imaging findings, qualitatively or quantitatively. Therefore, we multiparametric MRI information from both radiologists’ readings quantitative radiomics signatures construct a model that allows 5-year overall (OS) prediction...
Recurrence is the leading cause of death in hepatocellular carcinoma (HCC) patients with curative resection. In this study, we aimed to develop a preoperative predictive model based on high-throughput radiomics features and clinical factors for prediction long- short-term recurrence these patients.A total 270 HCC who were followed up at least 5 years after hepatectomy between June 2014 December 2017 enrolled retrospective study. Regions interest manually delineated T2-weighted images using...
Alemtuzumab, a humanized CD52 monoclonal antibody (mAb), has been used for immune induction in clinical small bowel transplantation (SBT). However, the local impact of mAb on transplanted intestine is not known. In this study, we investigated effects intestinal intraepithelial lymphocytes (iIELs) grafts using murine orthotopic SBT model. The antimouse was as surrogate antibody. Graft rejection assessed by histopathologic analysis, iIELs were isolated flow cytometric mucosal keratinocyte...
Objective To establish a stable murine models of orthotopic small bowel transplantation. Methods Syngeneic transplantation was performed between C57BL/6 mice. Donor intestinal graft harvested along with vascular pedicles (including graft's portal vein and the superior mesenteric artery Carrel patch aorta) by microsurgery. The donor intestine revascularized end-to-side arterial venous anastomoses. native cut off. enteric continuity reestablished end-to-end Microsurgical skills...
Atopic dermatitis (AD) is a skin disease. This study established mouse AD model to investigate the impact of PMMA (Poly(methyl methacrylate)) nanoparticles (PMMANPs) on epithelial cells. Nice ( n = 30) receiving no intervention were taken as healthy group, while other animals placed in group and sensitized with 2,4-Dinitrochlorobenzene (DNCB) acetone solution establish model. Skin cells backs mice assigned into blank control negative Hypoxia-Inducible Factor (HIF)-1 α + HIF-1 followed by...
INTRODUCTION: Colonic stenosis is a rare complication of acute pancreatitis (AP). It may be the consequence inflammation and necrosis caused by AP. Early intervention necessary, since progression colonic in AP leads to high mortality. We present case right colic flexure with total minimally invasive treatment. CASE DESCRIPTION/METHODS: A 73-year-old male patient severe due biliary lithiasis was transferred our hospital because recurrent infection fever at local hospital. The had upper lower...
Objective: To investigate the causes and treatment of severe acute pancreatitis (SAP) with iatrogenic duodenal fistula. Methods: The clinical data SAP patients fistula treated in Severe Acute Pancreatitis Center Sir Run Shaw Hospital from May 2015 to 2018 was analyzed retrospectively. Results: A total 11 were enrolled, among which 5 cases caused by injury, including 2 puncture nutritional tube injury 1 case drainage injury. For poor infection control after conservative treatment,...