A5100369009- Clinical Nutrition and Gastroenterology
- Pancreatitis Pathology and Treatment
- Abdominal Surgery and Complications
- Enhanced Recovery After Surgery
- Nutrition and Health in Aging
- Cancer-related molecular mechanisms research
- Appendicitis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Diverticular Disease and Complications
- Colorectal Cancer Surgical Treatments
- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Metabolism and Genetic Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Clostridium difficile and Clostridium perfringens research
- Barrier Structure and Function Studies
- Ferroptosis and cancer prognosis
- Intestinal and Peritoneal Adhesions
- Gastric Cancer Management and Outcomes
Wuhan University
2022-2024
Renmin Hospital of Wuhan University
2022-2024
Nanjing Medical University
2012-2024
Nanjing University of Chinese Medicine
2024
Nanjing Drum Tower Hospital
2022-2024
Nanjing University
2011-2023
Jiangnan University
2022-2023
Southwest Jiaotong University
2022-2023
Northeast Normal University
2023
Guangdong Medical College
2023
This study investigated the incidence of delayed norepinephrine administration following onset septic shock and its effect on hospital mortality.We conducted a retrospective cohort using data from 213 adult patients treated at two general surgical intensive care units tertiary over year period. The primary outcome was 28-day mortality.The mortality 37.6% overall. Among patients, strong relationship between initial noted. average time to 3.1 ± 2.5 hours. Every 1-hour delay in initiation...
Abstract Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role regulating energy metabolism. However, their significance extends beyond this, as they are also indispensable vital life processes such cell proliferation, differentiation, immune responses, and redox balance. In response to various physiological signals or external stimuli, sophisticated mitochondrial quality control (MQC) mechanism has evolved, encompassing key like biogenesis,...
The objective of this study was to investigate whether altering the fatty acid (FA) profile by omega-3 FA supplementation affects inflammatory response and systemic disease sequelae in severe acute pancreatitis.Forty pancreatitis patients were enrolled randomly assigned receive parenteral nutrition (PN) for 5 days a double-blind manner. Patients received PN with identical amounts amino acids (1.25 g/kg/d), glucose (3 fat (1 g/kg/d) but different lipid compositions: control group soybean oil...
Abstract Introduction Dysbiosis of intestinal microbiota likely plays an important role in the development gut-derived infections, making it a potential therapeutic target against sepsis. However, experience with fecal transplantation (FMT) treatment sepsis and knowledge underlying mechanisms are extremely lacking. In this article, we describe case patient who developed after vagotomy later received infusion donor feces microbiota, report our findings. Methods A 44-year-old woman septic...
Abstract Chemoresistance and relapse are the leading cause of AML-related deaths. Utilizing single-cell RNA sequencing (scRNA-seq), we dissected cellular states bone marrow samples from primary refractory or short-term relapsed AML patients defined transcriptional intratumoral heterogeneity. We found that compared to proliferating stem/progenitor-like cells (PSPs), a subpopulation quiescent stem-like (QSCs) were involved in chemoresistance poor outcomes AML. By performing longitudinal...
Male breast cancer (MBC) is a rare but aggressive malignancy with cellular and immunological characteristics that remain unclear. Here, we perform transcriptomic analysis for 111,038 single cells from tumor tissues of six MBC thirteen female (FBC) patients. We find has significantly lower infiltration T relative to FBC. Metastasis-related programs are more active in MBC. The activated fatty acid metabolism involved FASN related cell metastasis low immune show activation p38 MAPK lipid...
Abstract The disruption of intestinal epithelial tight junctions may result in barrier function dysfunction during polymicrobial sepsis. pathophysiology sepsis involves breakdown integrity, which correlates with adverse outcome However, the mechanisms underlying loss remain unknown. In present study mice, junction (TJ) structure was analysed by transmission electron microscopy; permeability assessed using molecular tracer measurement; and distribution TJ proteins investigated...
Introduction. To determine the effect of fecal microbiota transplantation (FMT) on quality life (QoL) in patients with inflammatory bowel disease (IBD). Methods. Fourteen IBD patients, including 11 Ulcerative colitis (UC) and 3 Crohn's (CD), were treated FMT via colonoscopy or nasojejunal tube infusion. QoL was measured by Questionnaire (IBDQ). Disease activity IBDQ evaluated at enrollment four weeks after treatment. Patients' attitude concerning treatment also investigated. Results. One...
Background: Fecal microbiota transplantation (FMT) has been proposed as a therapeutic approach for functional gastrointestinal disease. We launched clinical study to examine the safety and efficacy of FMT slow transit constipation (STC). Materials Methods: Twenty-four patients with STC, aged from 20 74 were enrolled in this prospective open-label study. Patients received on 3 consecutive days through nasojejunal tubes followed up 12 weeks after treatment. Rate improvement remission, Wexner...
Lack of enteral nutrition (EN) during parenteral (PN) leads to higher incidence infection because gut barrier dysfunction. However, the effects partial EN on intestina linnate immunity, intestinal alkaline phosphatase (IAP) and microbiota remain unclear. The mice were randomized into six groups receive either standard chow or isocaloric isonitrogenous nutritional support with variable PN ratios. Five days later, sacrificed tissue samples collected. Bacterial translocation, levels lysozyme,...
Nosocomial Methicillin-resistant Staphylococcus aureus (MRSA) enteritis is rare but can be fatal unless it detected at an early stage and treated effectively. Dysbiosis of the gut one leading reasons MRSA enteritis. Fecal microbiota transplantation (FMT) a burgeoning treatment to rectify this imbalance. But impact FMT on enterocoitis still unknown yet. A total 5 patients diagnosed as during postoperative period were given vancomycin 2 g/day for 3 days three continuous standard treatment....
A simple and accurate predictor of postoperative complications is needed for early safe discharge after surgery. decrease in serum albumin commonly observed surgery, even patients with normal preoperative levels. However, whether it predicts patient outcome unknown.The purpose this study was to evaluate the reduction within 2 days compared level could serve as an independent colorectal surgery.This a retrospective from single institution.The conducted tertiary referral hospital.A total 626...
Percutaneous cholecystostomy (PC) is an alternative treatment for acute cholecystitis (AC) in elderly patients with high surgical risk and has lower morbidity mortality than emergency cholecystectomy. There controversy about whether cholecystectomy should be performed after PC high-risk patients. Medical records of AC admitted to the Department Surgery, Jinling Hospital, Nanjing University School Medicine, China, between January 2004 July 2009 were reviewed retrospectively. The who underwent...
Objectives: To define the characteristic of bacteremia in patients with acute pancreatitis and determine its possible association disease severity. Design: A prospective controlled study. Setting: ICU Jinling Hospital, China. Patients: total 48 mild or severe were enrolled Interventions: None. Measurements Main Results: Samples peripheral blood collected from at 4 5 9 10 days after was definitely diagnosed. Resulting DNA analyzed using denaturing gradient gel electrophoresis, separated...