A5101675680- Pancreatitis Pathology and Treatment
- Abdominal Surgery and Complications
- Pancreatic and Hepatic Oncology Research
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Appendicitis Diagnosis and Management
- Muscle and Compartmental Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- COVID-19 Clinical Research Studies
- Dermatological and COVID-19 studies
- Hernia repair and management
- Clinical Nutrition and Gastroenterology
- Lipid metabolism and disorders
- SARS-CoV-2 and COVID-19 Research
- Thermal Regulation in Medicine
- Intensive Care Unit Cognitive Disorders
- Gastrointestinal disorders and treatments
- Acupuncture Treatment Research Studies
- Hemodynamic Monitoring and Therapy
- Streptococcal Infections and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Amoebic Infections and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Zhejiang University
2025
Integrated Chinese Medicine (China)
2022-2024
Jiangsu Provincial Academy of Traditional Chinese Medicine
2021-2024
Nanjing University of Chinese Medicine
2018-2024
Jiangsu Province Hospital
2016-2020
Tongde Hospital of Zhejiang Province
2019
Tongren Hospital
2017
Nanjing General Hospital of Nanjing Military Command
2010-2014
Nanjing University
2010-2014
Jinling Institute of Technology
2013-2014
The incidence of hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is increasing. Plasmapheresis theoretically effective in removing triglyceride from plasma, but whether it confers clinical benefits unclear.To assess the association between plasmapheresis and duration organ failure among patients with HTG-AP.This an a priori analysis data multicenter, prospective cohort study enrolled 28 sites across China. Patients HTG-AP were admitted within 72 hours disease onset. first patient...
No specific triglyceride-lowering therapy is recommended in patients with hypertriglyceridemia-associated acute pancreatitis (HTG-AP), primarily because of the lack quality evidence. This study aimed to describe practice variations therapies for early HTG-AP and assess whether more rapid triglyceride decline associated improving organ failure. a multicentre, prospective cohort recruiting elevated plasma (> 11.3 mmol/L) admitted within 72 h from onset symptoms. Patients were dichotomised on...
Chronic respiratory diseases pose a significant threat to global health, underscoring the urgent need for effective preventative and therapeutic interventions. The neutrophil-to-albumin ratio (NPAR), an emerging biomarker inflammation nutritional status, has shown promising associations with necessitating investigation into its potential predicting lung function decline. This study aimed delineate relationship between NPAR pulmonary within sample of American adult population assess viability...
Abstract Background/purpose Coagulative disorder is known to occur in the early phase of severe acute pancreatitis (SAP) and d ‐dimer a commonly used clinical parameter hemostasis. The aim this study was assess value plasma level as marker severity first 3 days after admission patients with SAP. Methods From January 2009 February 2011, 45 admitted for SAP were included observational study. measured on daily basis during 1‐3 physiology chronic health evaluation (APACHE) II score, sequential...
Objective To learn the clinical outcome of percutaneous catheter drainage (PCD) for patients with infective pancreatic necrosis and possible influencing factors. Methods A retrospective review medical records who received PCD as first choice treatment in recent 2 years. The were divided into groups: (1) success group (2) alteration group. Characteristics, complications, process compared. Results In this study, 19 34 cured by alone (55.9%), whereas open necrosectomy needed 15 (44.1%). Between...
BACKGROUND Surgical decompression is widely considered as an important treatment in patients with severe acute pancreatitis (SAP) and abdominal compartment syndrome (ACS). Until now, the indication optimal time of remain unknown, no experimental data exist, although extremely high mortality has been repeatedly reported these patients. The aim this study was to evaluate effects three different points for a 24-hour lasting porcine model. METHODS Following baseline registrations, 32 animals...
Introduction Abdominal compartment syndrome (ACS) and intra abdominal hypertension(IAH) are common clinical findings in patients with severe acute pancreatitis(SAP). It is thought that an increased pressure(IAP) associated poor prognosis SAP patients. But the detailed effect of IAH/ACS on different organ system not clear. The aim this study was to assess combined IAH hemodynamics, systemic oxygenation, damage a 12 h lasting porcine model. Measurements Methods Following baseline...
Abstract Background Plasmapheresis is widely used for severe hypertriglyceridemia-associated acute pancreatitis (HTG-AP) to remove excessive triglycerides from plasma. This study aimed evaluate whether plasmapheresis could improve the duration of organ failure in HTG-AP patients. Methods We analyzed a cohort patients multicenter, prospective, long-running registry (the PERFORM) collecting admitted sites within 72 h onset symptoms. was based on data collected November 2020 March 2023....
Objective: Administration of heparin or its derivatives has been proved to be beneficial in the treatment severe acute pancreatitis (SAP). However, drugs administered by conventional intravenous way are difficult reach pancreatic tissue and may cause bleeding complications due coagulation microcirculatory disturbance following initiation SAP. In this study, we aimed assess effects low-molecular-weight (LMWH) with continuous regional arterial infusion (CRAI) technique a porcine model Methods:...
This study evaluates the clinical efficacy of activated charcoal combined with mannitol (ACM) for treatment Haff disease. is a retrospective cohort conducted at Emergency Department Affiliated Hospital Integrated Traditional Chinese and Western Medicine. Consecutive patients who were hospitalized during two‐year time frame (from June 2016 to August 2017) diagnosed disease reviewed. Clinical symptoms, laboratory findings, pain/anxiety scores, treatment‐related adverse events collected....
This study aims to evaluate the feasibility and clinical utility of measuring cough decibel level as predictive markers for extubation outcomes in mechanically ventilated patients.
Vitamin D levels are generally lower in septic patients and associated with poor prognosis. Observational studies suggest improved renal recovery acute kidney injury (AKI) increased vitamin levels. Still, large RCTs did not show significant clinical benefits, possibly due to the limited number of sepsis or AKI included. This study aimed examine impact supplementation on 28-day all-cause mortality sepsis-associated (S-AKI).
Introduction Infected pancreatic necrosis (IPN) and its related septic complications are the major causes of death in patients with acute necrotising pancreatitis (ANP). Therefore, prevention IPN is great clinical value, immunomodulatory therapy thymosin alpha 1 may be beneficial. This study was designed to test hypothesis that administration during phase ANP will result a reduced incidence IPN. Methods analysis randomised, multicentre, double-blind, placebo-controlled study. 520 eligible...
Current techniques responsible for bladder cancer diagnosis and monitoring are insensitive invasive. Here, we report a surface-enhanced Raman scattering nanotag the sensitive of using urine samples as noninvasive approach. The sea-urchin-like Au nanoclusters used in this work exhibit excellent ability with an enhancement factor 3.44 × 107. Molecular beacons labeled Cy3 covalently anchored to surface nanoclusters, which serve specific recognition site survivin mRNA. Further polyethylene...
Immune-enhancing thymosin alpha 1 (Tα1) therapy may reduce infected pancreatic necrosis (IPN) in acute necrotising pancreatitis (ANP). However, the efficacy might be impacted by lymphocyte count due to pharmacological action of Tα1. In this post-hoc analysis, we tested hypothesis that pre-treatment absolute (ALC) determines whether patients with ANP benefit from Tα1 therapy. A analysis data a multicentre, double-blind, randomised, placebo-controlled trial testing predicted severe was...
Glutamine (Gln) supplementation is known to decrease oxidative stress and inflammatory response, enhance resistance infectious pathogens, shorten hospital stay, medical costs of patients. This study was undertaken evaluate the relationship between effect early parenteral glutamine supplement on acute liver injury (ALI) heat shock protein 70 (HSP-70) expression in critical patients.Forty-four patients who had been admitted emergency intensive care unit (EICU) Nanjing First Hospital Affiliated...
Hypertonic saline (HTS) solution resuscitation has been used in a variety of clinical settings. The aim this study was to assess the effect HTS on hemodynamics, systemic oxygenation, and organ damage porcine model severe acute pancreatitis.Eighteen anesthetized mechanically ventilated pigs were divided into 3 groups: group, lactated Ringer (LR) sham-operated group. Severe pancreatitis induced first 2 groups by injecting 5% sodium taurocholate pancreatic duct, investigation period 12 hours....