A5051103878- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- Renal Transplantation Outcomes and Treatments
- RNA modifications and cancer
- Asthma and respiratory diseases
- Gastrointestinal disorders and treatments
- Gallbladder and Bile Duct Disorders
- Long-Term Effects of COVID-19
- Clinical Nutrition and Gastroenterology
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
- Nutrition and Health in Aging
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cardiac, Anesthesia and Surgical Outcomes
- Dermatological and COVID-19 studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
Guangzhou Medical University
2014-2024
Guangzhou First People's Hospital
2014-2024
South China University of Technology
2019-2024
First Affiliated Hospital of Henan University of Science and Technology
2024
University of Michigan–Ann Arbor
2024
Affiliated Hospital of Nantong University
2014-2023
Nantong University
2014-2023
Second Affiliated Hospital of Nantong University
2014-2023
303 Hospital of People's Liberation Army
2023
Guangxi Medical University
2023
Exosomes secreted from stem cells exerted salutary effects on the fibrotic liver. Herein, roles of exosomes derived human embryonic cell (hESC) in anti-fibrosis were extensively investigated. Compared with two-dimensional (2D) culture, clinical and biological relevance three-dimensional (3D) spheroids greater because their higher regeneration potential since they behave more like vivo. In our study, 3D monolayer hESCs collected compared therapeutic for liver vitro vitro, PKH26...
The incidence of hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is increasing. Plasmapheresis theoretically effective in removing triglyceride from plasma, but whether it confers clinical benefits unclear.To assess the association between plasmapheresis and duration organ failure among patients with HTG-AP.This an a priori analysis data multicenter, prospective cohort study enrolled 28 sites across China. Patients HTG-AP were admitted within 72 hours disease onset. first patient...
New therapeutic drug for breast cancer (BRCA), especially triple negative BRCA (TNBC), is urgently needed. Even though 2-(4-morpholinoanilino)-6-cyclohexylaminopurine (reversine) an aurora kinase inhibitor, it also inhibits some cells and human cells. However, the potential roles of reversine as a novel agent treatment remains unknown must be further investigation. Thus, relationship to in BCRA has not been reported. The between AURKB survival rate never Herein, we tested on different cell...
Integrin β1 (ITGB1), which acts as an extracellular matrix (ECM) receptor, has gained increasing attention a therapeutic target for the treatment of hepatocellular carcinoma (HCC). However, underpinning mechanism how ITGB1 drives HCC progression remains elusive. In this study, we first found that expression was significantly higher in tissues than normal controls by bioinformatics analysis. Furthermore, analysis revealed paxillin (PXN) and 14-3-3 protein zeta (YWHAZ) are molecules...
No specific triglyceride-lowering therapy is recommended in patients with hypertriglyceridemia-associated acute pancreatitis (HTG-AP), primarily because of the lack quality evidence. This study aimed to describe practice variations therapies for early HTG-AP and assess whether more rapid triglyceride decline associated improving organ failure. a multicentre, prospective cohort recruiting elevated plasma (> 11.3 mmol/L) admitted within 72 h from onset symptoms. Patients were dichotomised on...
Synopsis After measurement of individual growth rates, natural hair fibres from Asian and Caucasian subjects were analysed using scanning electron microscopy. In total, more than 1000 hairs analysed. Measurements diameter, medulla interscale distance (average between two successive cuticle scales) show these parameters strongly correlated with rate. A thicker fibre corresponds to a faster rate, shorter greater probability have medulla, vice versa , thin shows slower larger lower medulla....
Liver disease imposes a significant medical burden that persists due to shortage of liver donors and an incomplete understanding progression. Hepatobiliary organoids (HBOs) could provide in vitro mini-organ model increase the may benefit development regenerative medicine. In this study, we aimed establish HBOs with bile duct (BD) structures mature hepatocytes (MHs) using human chemically induced progenitor cells (hCLiPs). hCLiPs were cryo-hepatocytes small-molecule cocktail TGF-β inhibitor...
Anti-inflammation strategy is one of the proposed therapeutic approaches to hepatic fibrosis. IL-17 critical in inflammation, but role liver fibrosis has not yet been elucidated. In this study, we investigate on bile duct ligation-induced injury and C57BL/6 mice. Animals were sacrificed at designated times, serum tissues collected for analysis function IL-6, IL-1β, tumour necrosis factor-alpha (TNF-α) transforming growth factor-β (TGF-β) levels. blockade with anti-IL-17A mAb significantly...
Angiotensin receptor blockers have been reported to be beneficial liver fibrosis, but the relevant molecular and cellular mechanisms remain unclear. We herein investigated whether low-dose angiotensin blocker alleviated fibrosis through mechanotransduction regulation. Hydrostatic pressure-induced model was established in mice by ligating partially inferior vena cava, then randomly received a very low dose of losartan (0.5 mg/kg) or placebo treatment for 8 weeks. found that administration...
The integration of a bile drainage structure into engineered liver tissues is an important issue in the advancement regenerative medicine. Primary biliary cells, which play vital role metabolite accumulation, are challenging to obtain vitro because their low density liver. In contrast, large amounts purified hepatocytes can be easily acquired from rodents. chemically induced progenitors (CLiPs) primary mature offer platform produce cells abundantly. Here, we generated functional CLiP-derived...
Ductular reaction (DR) is usually observed in biliary disorders or various liver disorders, including nonalcoholic fatty disease. Few studies have focused on interrupting the DR process cholestatic environment. Here, we investigated impact of reversine rats that had undergone bile duct ligation (BDL). Cholestatic injury was induced 2 weeks following BDL. assessed with markers by immunohistochemistry. Biliary epithelial cells (BECs) were isolated for analysis proliferation and factor gene...
This study aimed to investigate the indocyanine green (ICG) dose in real-time fluorescent cholangiography during laparoscopic cholecystectomy (LC) with a 4K system. A randomized controlled clinical trial was conducted patients who underwent LC for treatment of cholelithiasis. Using OptoMedic endoscopic system, we compared four different doses ICG (1, 10, 25, and 100 µg) administered intravenously within 30 min preoperatively evaluated fluorescence intensity (FI) common bile duct liver...
Tricuspid valve reoperation (TVR) following left-sided surgery (LSVS) is a high-risk procedure. This study was conducted to analyse the mid-term results and risks of isolated TVR LSVS.From May 2007 December 2016, 91 patients who underwent LSVS were enrolled in this study.The comprised 23 men 68 women with mean age 57.5 ± 8.0 years (range 33-75 years). The in-hospital mortality rate 2.2% (2 patients). Fourteen (15.4%) procedures performed through median sternotomy, whereas 77 (84.6%) right...
Elevated interstitial fluid hydrostatic pressure is commonly observed in diseased livers. We herein examined the hypothesis that induces hepatic stellate cells to acquire profibrotic properties under pathological conditions. Human were exposed 50 mmHg for 24 h. Although we few changes of cell growth and morphology, PCR array data on expression fibrosis-associated genes suggested acquisition properties. The exposure h also significantly enhanced RhoA, ROCK1, α-SMA, TGF-β1 , p-MLC, p-Smad2,...
Upon injury, the liver is capable of substantial regeneration from original tissue until an appropriate functional size. The underlying mechanisms controlling processes are not well elucidated. Previous studies have proposed that transcription factor FoxO3 involved in various diseases, but its exact role regulation remains largely unclear. To directly test detailed regeneration, both a constitutive Albumin-Cre driver line and adeno-associated virus serotype 8 (AAV8)-Tbg-Cre...