A5008175729- Liver physiology and pathology
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
- Oral and Maxillofacial Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related gene regulation
- Angiogenesis and VEGF in Cancer
- Biochemical and Molecular Research
- Gastrointestinal disorders and treatments
- Cancer-related molecular mechanisms research
- Parkinson's Disease and Spinal Disorders
- Pelvic floor disorders treatments
- Myasthenia Gravis and Thymoma
- Metabolism and Genetic Disorders
- 14-3-3 protein interactions
- Vascular Procedures and Complications
- Alcohol Consumption and Health Effects
- Enhanced Recovery After Surgery
- Muscle metabolism and nutrition
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
South China University of Technology
2025
Guangzhou Medical University
2025
Guangzhou First People's Hospital
2025
First Affiliated Hospital of Guangdong Pharmaceutical University
2018-2024
National Cheng Kung University Hospital
2024
Exosomes secreted from stem cells exerted salutary effects on the fibrotic liver. Herein, roles of exosomes derived human embryonic cell (hESC) in anti-fibrosis were extensively investigated. Compared with two-dimensional (2D) culture, clinical and biological relevance three-dimensional (3D) spheroids greater because their higher regeneration potential since they behave more like vivo. In our study, 3D monolayer hESCs collected compared therapeutic for liver vitro vitro, PKH26...
Integrin β1 (ITGB1), which acts as an extracellular matrix (ECM) receptor, has gained increasing attention a therapeutic target for the treatment of hepatocellular carcinoma (HCC). However, underpinning mechanism how ITGB1 drives HCC progression remains elusive. In this study, we first found that expression was significantly higher in tissues than normal controls by bioinformatics analysis. Furthermore, analysis revealed paxillin (PXN) and 14-3-3 protein zeta (YWHAZ) are molecules...
Lipid storage myopathies (LSM) are a group of inherited metabolic muscle disorders characterized by abnormal lipid metabolism and the deposition lipids within fibers. Multiple acyl-coenzyme A dehydrogenase deficiency (MADD) is most common type LSM in China, caused mutations gene expressing electron transfer flavoprotein (ETFDH). Here, we report 14-year-old girl presenting with exercise intolerance, followed weakness pain. Initially, patient showed rhabdomyolysis (RML) was misdiagnosed...
Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies that target the neuromuscular junction, leading to muscle weakness and fatigability. Diagnosis based on clinical presentation, confirmation of presence AChR-Ab, characteristic electromyography findings, improvement after administration acetylcholinesterase inhibitors.MG often associated with thymoma other diseases, but it rare following allo-HSCT. we reports two cases MG transplantation, including first case...
Hepatocellular carcinoma (HCC) with high incidence and mortality is one of the most common malignant cancers worldwide. Increasing evidence has reported that N6-methyladenosine (m6A) modification been considered as a major contribution to occurrence development tumors.In our study, we comprehensively analyzed connection between m6A regulatory factors cancer stem cells (CSCs) HCC establish clinical tool for predicting its outcome. First, concluded expression level was related stemness...
A 3D tumor-driven angiogenesis model incorporating endothelial cells and pericytes was established to investigate the effects of anti-angiogenic agents on pericyte recruitment in a rapid reproducible way.
Background. Solute carrier (SLC) proteins play an important role in tumor metabolism. But SLC-associated genes’ prognostic significance hepatocellular carcinoma (HCC) remained elusive. We identified SLC-related factors and developed classifier to predict improve HCC prognosis treatment. Methods. From the TCGA database, corresponding clinical data mRNA expression profiles of 371 patients were acquired, those 231 samples derived from ICGC database. Genes associated with features filtered using...
Liver cancer stem cells (LCSCs) are thought to drive the metastasis and recurrence, however, heterogeneity of molecular markers LCSCs has hindered development effective methods isolate them. This study introduced an approach culture from human primary liver (HPLC), leveraging mouse embryonic fibroblasts (MEFs) as feeder in conjunction with using defined medium. Isolated were further characterized by multiple approaches. Transcriptome sequencing data analysis was conducted identify highly...
e24276 Background: Hepatocellular carcinoma (HCC), the most common hepatic malignancy, is second leading cause of cancer-related death worldwide. China accounts for more than 50% new HCC cases and deaths in world. The genomic profiles Chinese patients had not been thoroughly elucidated to facilitate diagnosis treatment. Methods: FFPE tumor matched blood samples 181 patients, including 152 males (median age 54) 29 females 52), were collected next-generation sequencing-based 450 genes panel...
Microsatellite stable /microsatellite instable-low is the most common colorectal cancer genotype, counting for approximately 85% of patients. Treatment advanced microsatellite stable/microsatellite difficult and successful pharmacological treatment options are currently lacking. Here, we report a case 37-year-old man with genotyping Kirsten rat sarcoma viral oncogene (G12V) mutation. Following palliative surgery, patient did not response to recommended chemotherapy FOLFIRI regimen other...
Abstract BackgroundExosomes secreted from stem cells exerted salutary effects on the fibrotic liver. Herein, roles of exosomes derived human embryonic cell (hESC) in anti-fibrosis were extensively investigated. Compared with two-dimensional (2D) culture, clinical and biological relevance three-dimensional (3D) spheroids greater because their higher regeneration potential since they behave more like vivo. In our study, 3D monolayer hESCs collected compared therapeutic for liver vitro...
Abstract Background Excessive alcohol consumption has been documented to increase the risk of liver hepatocellular carcinoma (HCC) development. Accordingly, a broad interest pointed dehydrogenases (ADHs), which display essential roles in metabolism. Despite relevance ADHs expression and prognosis HCC estimated, so far, limited research concerning factors that are responsible for regulation reported. Methods In this study, using The Cancer Genome Atlas (TCGA) RegNetwork database, we predicted...