A5100612760- Pediatric Hepatobiliary Diseases and Treatments
- Ferroptosis and cancer prognosis
- Sarcoma Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA modifications and cancer
- Heavy Metal Exposure and Toxicity
- Gallbladder and Bile Duct Disorders
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Advanced Causal Inference Techniques
- Mathematical and Theoretical Epidemiology and Ecology Models
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Respiratory Support and Mechanisms
- Oral and Maxillofacial Pathology
- Colorectal Cancer Screening and Detection
- Kidney Stones and Urolithiasis Treatments
- Environmental Toxicology and Ecotoxicology
- Mercury impact and mitigation studies
- Bone Tumor Diagnosis and Treatments
- Evolution and Genetic Dynamics
Affiliated Hospital of Qingdao University
2025
Qingdao University
2025
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Soochow University
2024
Guangzhou Medical University
2020-2023
Guangzhou First People's Hospital
2022-2023
Zhejiang University of Technology
2023
South China University of Technology
2023
Southern Medical University
2023
Nanfang Hospital
2023
Late-stage hepatocellular carcinoma (HCC) usually has a low survival rate because of the high risk metastases and lack an effective cure. Disulfiram (DSF) copper (Cu)-dependent anticancer properties in vitro vivo. The present work aims to explore anti-metastasis effects molecular mechanisms DSF/Cu on HCC cells both results showed that DSF inhibited proliferation, migration invasion cells. Cu improved anti-metastatic activity DSF, while alone had no effect. Furthermore, NF-κB TGF-β...
The contamination of uranium in aquatic ecosystems has raised growing global concern. However, the understanding its chronic effects on organisms is limited, particularly with regards to transgenerational toxicity. In this study, we evaluated maternal transfer risk using zebrafish. Sexually mature female zebrafish were exposed 2 and 20 ng/g uranium-spiked food for 28 days. induced bioconcentration, thyroid disruption, oxidative stress both adults (F0) their embryos (F1) further investigated....
Ductular reaction (DR) is usually observed in biliary disorders or various liver disorders, including nonalcoholic fatty disease. Few studies have focused on interrupting the DR process cholestatic environment. Here, we investigated impact of reversine rats that had undergone bile duct ligation (BDL). Cholestatic injury was induced 2 weeks following BDL. assessed with markers by immunohistochemistry. Biliary epithelial cells (BECs) were isolated for analysis proliferation and factor gene...
This study aimed to investigate the indocyanine green (ICG) dose in real-time fluorescent cholangiography during laparoscopic cholecystectomy (LC) with a 4K system. A randomized controlled clinical trial was conducted patients who underwent LC for treatment of cholelithiasis. Using OptoMedic endoscopic system, we compared four different doses ICG (1, 10, 25, and 100 µg) administered intravenously within 30 min preoperatively evaluated fluorescence intensity (FI) common bile duct liver...
Hepatocellular carcinoma (HCC) with high incidence and mortality is one of the most common malignant cancers worldwide. Increasing evidence has reported that N6-methyladenosine (m6A) modification been considered as a major contribution to occurrence development tumors.In our study, we comprehensively analyzed connection between m6A regulatory factors cancer stem cells (CSCs) HCC establish clinical tool for predicting its outcome. First, concluded expression level was related stemness...
Background: We sought to determine whether circulating inflammatory biomarkers were associated with the frequent exacerbator phenotype in stable COPD patients ie, those two or more exacerbations previous year. Methods: Eighty-eight stable, severe, (4 females) assessed for exacerbation frequency, pulmonary function, fraction of expired nitric oxide (F E NO); variables measured venous blood. Logistic regression associations between and systemic inflammation. Results: Compared infrequent...
Ferroptosis is an iron-dependent programmed cell death mechanism that influences the development of malignancy. Lung adenocarcinoma (LUAD) most common type lung cancer with no known cure. Anti-PD-1/PD-L immunotherapy effective for patients partial LUAD. Therefore, there immediate requirement novel markers to predict individualised benefits immunotherapy.We manually collected ferroptosis-related gene (FERG) set and employed Wilcoxon rank-sum test identify differentially expressed FERGs....
Giant cell tumors of the bone are generally benign bone, though they can be locally invasive in nature. They also known as "osteoclastomas," and patients typically between 20 40 years age, who present with pain swelling joints. Though tumor is benign, malignant degeneration, metastasis, other complications growth possible. Here we a case where delay treatment led to significant burden. This tumor's unique location anterior arc rib, well its size that has rarely been reported, ultimately...
Prostate cancer (PCa) contributes to more than 1.2 million newly diagnosed cases and 350,000 deaths each year, making it the second most common malignancy fifth leading cause of cancer-related in men worldwide. Treatment PCa is further complicated by drug resistance enzalutamide. The present study comprehensively details genomic characteristics enzalutamide-resistant PCa.The determination enzalutamide-related genes GSE163240 GSE136129 was conducted differential expression analysis, gene set...
Abstract Background: We sought to determine whether circulating inflammatory biomarkers were associated with the frequent exacerbator phenotypein stable COPD patients i.e. those two or more exacerbations in previous year. Methods: 88 stable, severe, (4 females)were assessed for exacerbation frequency, pulmonary function, fraction of expired nitric oxide (F E NO);inflammatory variables measured venous blood. Logistic regression associations between phenotype and systemic inflammation....
Abstract Aims : This study aimed to investigate the indocyanine green (ICG) dose in real‐time fluorescent cholangiography during laparoscopic cholecystectomy (LC) with a 4K system. Methods A randomized controlled clinical trial was conducted patients who underwent LC for treatment of cholelithiasis. Using OptoMedic endoscopic system, we compared four different doses ICG (1, 10, 25, and 100 µg) administered intravenously within 30 min preoperatively evaluated fluorescence intensity (FI)...