A5100378114- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Pediatric health and respiratory diseases
- Circular RNAs in diseases
- Pulmonary Hypertension Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Diabetes and associated disorders
- Cancer-related molecular mechanisms research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Acute Myeloid Leukemia Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes Management and Research
- Memory and Neural Mechanisms
- Inhalation and Respiratory Drug Delivery
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Obstructive Sleep Apnea Research
- Chronic Disease Management Strategies
- Mitochondrial Function and Pathology
- Respiratory and Cough-Related Research
Central South University
2016-2025
Second Xiangya Hospital of Central South University
2016-2025
Hunan Provincial Center for Disease Control and Prevention
2018-2025
Zhejiang University of Technology
2018-2025
Xiangya Hospital Central South University
2003-2025
Kunming University of Science and Technology
2011-2025
First People's Hospital of Yunnan Province
2025
Zhejiang Ocean University
2025
Soochow University
2018-2024
Nanjing Medical University
2015-2024
How to link and separate memories Engrams are the changes in brain tissue that store single memories. Neuroscientists can localize manipulate them, but until now, little was known about how multiple engrams interact influence Rashid et al. examined neural assemblies an area called lateral amygdala interact. If two frightening events occurred within 6 hours, same set of neurons used express fear for both events. However, if were separated by 24 distinct memory traces formed. Science , this...
The preferred timing of umbilical-cord clamping in preterm infants is unclear.We randomly assigned fetuses from women who were expected to deliver before 30 weeks gestation either immediate the umbilical cord (≤10 seconds after delivery) or delayed (≥60 delivery). primary composite outcome was death major morbidity (defined as severe brain injury on postnatal ultrasonography, retinopathy prematurity, necrotizing enterocolitis, late-onset sepsis) by 36 postmenstrual age. Analyses performed an...
Patients with mild or moderate chronic obstructive pulmonary disease (COPD) rarely receive medications, because they have few symptoms. We hypothesized that long-term use of tiotropium would improve lung function and ameliorate the decline in patients COPD.
Vac8p is a vacuolar membrane protein that required for efficient vacuole inheritance and fusion, cytosol-to-vacuole targeting, sporulation. By analogy to other armadillo domain proteins, including β-catenin importin α, we hypothesize docks various factors at the membrane. Two-hybrid copurfication assays demonstrated does form complexes with multiple binding partners, Apg13p, Vab2p, Nvj1p. Here describe surprising role of Vac8p-Nvj1p in formation nucleus–vacuole (NV) junctions. Nvj1p an...
Experience with drugs of abuse (such as cocaine) produces powerful, long-lasting memories that may be important in the development and persistence drug addiction. The neural mechanisms mediate how where these cocaine are encoded, consolidated stored unknown. Here we used conditioned place preference mice to examine precise circuits support memory a cocaine-cue association (the "cocaine trace" or engram"). We found small population neurons (∼10%) lateral nucleus amygdala (LA) were recruited...
We demonstrate the use of cryogenic super-resolution correlative light and electron microscopy (csCLEM) to precisely determine spatial relationship between proteins their native cellular structures. Several fluorescent (FPs) were found be photoswitchable emitted far more photons under our imaging condition, resulting in higher localization precision which is comparable ambient imaging. Vitrified specimens prepared by high pressure freezing cryo-sectioning maintain a near-native state with...
Angiotensin II (Ang II) aggravates hepatic fibrosis by inducing NADPH oxidase (NOX)-dependent oxidative stress. Angiotensin-(1-7) [Ang-(1-7)], which counter-regulates Ang II, has been evidenced to protect against fibrosis. The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, being activated reactive oxygen species (ROS), is identified as a novel mechanism of liver However, whether the NLRP3 inflammasome involves in regulation II-induced remains unclear. This study...
Abstract Background The clinical outcomes of COVID-19 patients in Hubei and other areas are different. We aim to investigate the epidemiological characteristics patient with Hunan which is adjacent Hubei. Methods In this double-center, observational study, we recruited all consecutive laboratory confirmed from January 23 February 14, 2020 two designated hospitals province, China. Epidemiological data patients’ electronic medical records were collected compared between mild, moderate...
<h3>Importance</h3> Poor diet is a major risk factor for chronic diseases, disability, and death in the US. As older adults comprise fastest-growing population segment US, it crucial to describe dietary trends among identify opportunities challenges improving health old age. <h3>Objective</h3> To characterize overall quality key food components nutrients US by age, sex, race ethnicity, marital status, educational level, income. <h3>Design, Setting, Participants</h3> This serial...
Overcoming distant metastasis stands as a paramount challenge in enhancing the outcomes of breast cancer treatments. Thus, delving deeper into comprehending intricate mechanisms underlying becomes imperative, offering potential avenues for pioneering therapeutic approaches. PRMT6, an arginine N-methyltransferase, possesses ability to methylate both histone and non-histone proteins. It has been reported that methylation proteins impacts their cellular localization, stability, activation,...
Puncturing is widely used to generate rate-compatible codes. However, for punctured polar codes, some puncturing patterns may greatly affect the split bit channels and cause considerable performance loss. In this paper, we aim investigate how are affected by various patterns, then evaluate performances of these patterns. We propose a search algorithm design good prove that designing optimal pattern output bits equivalent finding frozen bits. also heuristic approach based on idea polarization...
Leveraging the conserved cancer genomes across mammals has potential to transform driver gene discovery in orphan cancers. Here, we combine cross-species genomics with validation human-dog-mouse systems uncover a new bone tumor suppressor gene. Comparative of spontaneous human and dog osteosarcomas (OS) expose Disks Large Homolog 2 (DLG2) as candidate. DLG2 copy number loss occurs 42% 56% canine OS. Functional through pertinent OS DLG2-deficient cell lines identifies regulatory role...